Explanipedia

AI-informed retinal biomarkers predict 10-year risk of onset of multiple hematological malignancies Open

Amritpal Singh, Ajay K. Nooka, Gourav Modanwal, Nieraj Jain, Madhav V. Dhodapkar , et al. · 2025

Pigmentary Maculopathy in Patients with Interstitial Cystitis: Association with Pentosan Polysulfate and Other Therapies Open

Sunny Qin, Joni K. Evans, Chaewon Jeong, Margaret Havunjian, Nieraj Jain , et al. · 2025

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Colopathy associated with pentosan polysulfate use Open

Emily H. Jung, Wei Zheng, Ryan J. Weiss, Namita E. Mathew, Benjamin I. Meyer , et al. · 2025

Introduction We describe a novel colopathy associated with pentosan polysulfate (PPS) use and assess the strength of the drug-disease association in a two-part investigation. Methods 1. Cohort Study: We studied individuals with a history o…

Coring of Intravitreal Medication Vial Stoppers: A Report From the Research and Safety in Therapeutics Committee of the American Society of Retina Specialists Open

Ferhina S. Ali, Eric W. Schneider, Sruthi Arepalli, Durga S. Borkar, Jordan D. Deaner , et al. · 2025

In 2024, the American Society of Retina Specialists (ASRS) Research and Safety in Therapeutics (ReST) Committee became aware of reports of coring of vial stoppers in relation to preparation of intravitreal injections. A literature review w…

Variants in CFAP410 cause a range of retinal and skeletal phenotypes Open

Reinhold E. Schmidt, Amy E. Pohodich, David G. Birch, Kaylie Webb-Jones, Byron L. Lam , et al. · 2025

Is there evidence for changes in antibiotic resistance of microorganisms causing postcataract surgery endophthalmitis: a systematic review Open

Christina J. Flaxel, Justine Smith, Nieraj Jain, Leo A. Kim, Stephen J. Kim , et al. · 2025

Background/Aims To review the evidence for changes in antibiotic resistance patterns before and after cataract surgery since the advent of routine use of intracameral (IC) antibiotic prophylaxis and development of newer topical fluoroquino…

Reduced retinal microvascular density in women with coronary microvascular dysfunction: A pilot study Open

Sakshi Shiromani, Ahmed AlBadri, Aaron Lindeke-Myers, Arielle Schwartz, Nishant Vatsa , et al. · 2025

Public Awareness of a Vision-Threatening Toxicity: Infodemiology in Pentosan Polysulfate Maculopathy (Preprint) Open

Sakshi Shiromani, Kunjal Kothari, Emily H. Jung, Nieraj Jain · 2024

BACKGROUND In this age of information (and misinformation), the ophthalmology community faces an ongoing challenge in shaping the distribution of information regarding ophthalmic health to the lay public. Our infodemiology study yields un…

Pentosan Polysulfate Sodium Causes Diminished Function and Subtle Morphological Changes in Retina and RPE of Mice Open

Preston Girardot, Xian Zhang, Nan Zhang, Kevin J. Donaldson, Micah A. Chrenek , et al. · 2024

PPS treatment reduced RPE and later retina function as measured by ERG, consistent with a primary RPE injury. Post-mortem analysis revealed extensive RPE pleomorphism and polymegathism and modest photoreceptor changes. We conclude that PPS…

Pentosan Polysulfate Maculopathy With 13 Years of Follow-up Imaging Open

Ashlyn Pinto, Nieraj Jain, R. Rishi Gupta · 2024

Purpose: To describe a case of pentosan polysulfate maculopathy progression with 13 years of follow-up imaging. Methods: A case was analyzed and a literature review performed. Results: A 65-year-old woman was referred to the retina service…

Artificial Intelligence Chatbot Performance in Triage of Ophthalmic Conditions Open

Riley J. Lyons, Sruthi R. Arepalli, Ollya Fromal, Jinho D. Choi, Nieraj Jain · 2023

Importance Access to human expertise for affordable and efficient triage of ophthalmic conditions is inconsistent. With recent advancements in publicly available artificial intelligence (AI) chatbots, individuals may turn to these tools fo…

Colopathy Associated with Pentosan Polysulfate Use Open

Emily H. Jung, Wei Zheng, Ryan J. Weiss, Namita E. Mathew, Benjamin I. Meyer , et al. · 2023

Introduction We describe a novel colopathy associated with pentosan polysulfate (PPS) use and measure the strength of the drug-disease association. Methods Two-part investigation. In the cohort study of individuals with a history of prior …

Two-Year Outcomes After Variable Duration of Drug Cessation in Patients With Maculopathy Associated With Pentosan Polysulfate Use Open

Emily H. Jung, Aaron Lindeke-Myers, Nieraj Jain · 2023

Importance Prior retrospective studies have provided limited evidence on disease progression following drug cessation in patients with maculopathy associated with pentosan polysulfate (PPS). Objective To evaluate the 2-year evolution of ma…

Pentosan polysulfate maculopathy: Keep an eye out for this masquerader Open

Nieraj Jain, Emily H. Jung · 2022

Pentosan polysulfate sodium (PPS) (Elmiron; Janssen Pharmaceuticals), a drug used to treat bladder pain and discomfort associated with interstitial cystitis (IC), has been linked to a distinctive vision-threatening maculopathy. As with the…

Pentosan Polysulfate Maculopathy: Prospective Longitudinal Study of Disease Course after Drug Cessation Open

Aaron Lindeke-Myers, Riley J. Lyons, Judy Brower, Nieraj Jain · 2021

Patient-reported visual functioning in persons with bi-allelic USH2A variants Open

Elise Héon, Michele Melia, Laura E. Bocchino, Jacque L. Duncan, Allison R. Ayala , et al. · 2021

Prospective Analysis of Patient Satisfaction with Inherited Retinal Disease Clinic Visits Conducted via a Hybrid Telemedicine-based Approach Open

Aditya Rali, Stacy Partin, Jiong Yan, Nieraj Jain · 2021

Purpose : The COVID-19 pandemic adversely impacted patient access to in-person healthcare, bringing telemedicine to the forefront. The Emory Ophthalmic Genetics Service (EOGS) adopted a hybrid model of care, allowing patients to meet the p…

Long-term Systemic Pentosan Polysulfate Administration Causes Retinal Function Decrease with Changes in Cell Markers Open

Preston Girardot, Xian Zhang, Micah A. Chrenek, Jana T Sellers, Nan Zhang , et al. · 2021

Pentosan polysulfate maculopathy Open

Aaron Lindeke-Myers, Xiaodong Zhang, Nieraj Jain · 2021

Patient Perceptions of SARS-CoV-2 Exposure Risk and Association With Continuity of Ophthalmic Care Open

Aaron Lindeke-Myers, Peter Y. Zhao, Benjamin I. Meyer, Elaine A. Liu, David A. Levine , et al. · 2021

Among patients at high risk for vision loss from lapses in care, many expressed concerns regarding the effect of the pandemic on their ability to receive timely care. Survey results suggest that fear of SARS-CoV-2 exposure was associated w…

PENTOSAN POLYSULFATE AND VISION Open

Ogul E. Uner, Megha Shah, Nieraj Jain · 2020

Purpose: To investigate patient-reported visual function among individuals taking pentosan polysulfate (PPS) for interstitial cystitis. Methods: A 27-item online survey was distributed to an international mailing list of individuals with i…

Visual Function in Pentosan Polysulfate Sodium Maculopathy Open

Riley J. Lyons, Judy Brower, Nieraj Jain · 2020

PPS maculopathy causes considerable visual function degradation that is not fully captured with BCVA testing. There was good correlation between other measures of visual function and disease severity. These findings deepen our concern rega…

Disease Course in Patients With Pentosan Polysulfate Sodium–Associated Maculopathy After Drug Cessation Open

Rachel Shah, Joseph M. Simonett, Riley J. Lyons, Rajesh C. Rao, Mark E. Pennesi , et al. · 2020

These retrospective data among 11 patients suggest PPS-associated maculopathy continues to evolve after drug cessation for at least 10 years. In some cases, progressive retinal pigment epithelium atrophy encroaches on the foveal center and…

Rubber Bullet Ocular Trauma Open

Alexander C. Barnes, Lauren E. Hudson, Nieraj Jain · 2020

Characteristics and Outcomes of Patients with Non-Paraneoplastic Autoimmune Retinopathy Open

Lucy T. Xu, Jessica G. Shantha, Steven Yeh, Jiong Yan, G. Baker Hubbard , et al. · 2020

Pentosan Polysulfate Maculopathy: Findings from an International Survey of Exposed Individuals Open

Ogul E. Uner, Laura Ward, Megha Shah, Nieraj Jain · 2020

Pentosan Polysulfate Maculopathy: Comprehensive Functional Analysis and Structure-Function Correlation Open

Riley J. Lyons, Xiaodong Zhang, Nieraj Jain · 2020

Pentosan polysulfate maculopathy versus age-related macular degeneration: comparative assessment with multimodal imaging Open

Joseph Christiansen, Alexander C. Barnes, Duncan Berry, Nieraj Jain · 2020

OBJECTIVE To evaluate whether pentosan polysulfate maculopathy manifests distinctive imaging features that can be differentiated from those found in age-related macular degeneration (AMD). METHODS Local databases were queried to identify p…

Dopamine metabolite levels in the vitreous of diabetic and non-diabetic humans Open

Andrew Hendrick, Jesse M. Smith, Chris Stelton, Scott Barb, Jiong Yan , et al. · 2020

Association of macular disease with long-term use of pentosan polysulfate sodium: findings from a US cohort Open

Nieraj Jain, Alexa L. Li, Yinxi Yu, Brian L. VanderBeek · 2019

Background/Aims A series at a single clinical centre recently demonstrated an association between the interstitial cystitis drug pentosan polysulfate sodium (PPS) and a vision-threatening pigmentary maculopathy. The aim of this study was t…

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