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View article: Age- and sex-specific lipoprotein profiles in general and cardiometabolic population cohorts
Age- and sex-specific lipoprotein profiles in general and cardiometabolic population cohorts Open
The specific funding of this article is provided in the acknowledgements section.
View article: High-precision Biomedical Text Corpora for Multi-Entity Recognition: A CoDiet study
High-precision Biomedical Text Corpora for Multi-Entity Recognition: A CoDiet study Open
We present here four biomedical, multi-entity corpora that can be used as benchmarks for named-entity recognition (NER), targeted to literature on metabolic syndrome. The CoDiet-Gold corpus (348,413 annotations) contains 500 re-distributab…
View article: Metabolomic-based aging clocks
Metabolomic-based aging clocks Open
Molecular aging clocks estimate biological age from molecular biomarkers and often outperform chronological age in predicting health outcomes. Types include epigenetic, transcriptomic, proteomic, and metabolomic clocks. NMR-based metabolom…
View article: Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum
Nuclear Magnetic Resonance Analysis Seeking for Metabolic Markers of Hypertension in Human Serum Open
Hypertension is a highly prevalent medical condition that occurs when blood pressure is too high, which greatly increases the risk of developing other cardiovascular diseases and is generally associated with higher rates of morbidity and m…
View article: Multi-omic integration sets the path for early prevention strategies on healthy individuals
Multi-omic integration sets the path for early prevention strategies on healthy individuals Open
Precision medicine requires biomarkers that stratify patients and improve clinical outcomes. Although longitudinal multi-omic analyses provide insights into pathological states, their utility in stratifying healthy individuals remains unde…
View article: Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma
Benchtop Proton NMR Spectroscopy for High-Throughput Lipoprotein Quantification in Human Serum and Plasma Open
We report the successful development and translation of high-field nuclear magnetic resonance (NMR) based comprehensive lipoprotein analysis to routine benchtop systems. This demonstrates the potential to reimagine population level cardiov…
View article: Using wearable camera dietary monitoring technology to explore diet-related non-communicable disease in volunteers at risk of cardiovascular disease - the CoDiet study protocol.
Using wearable camera dietary monitoring technology to explore diet-related non-communicable disease in volunteers at risk of cardiovascular disease - the CoDiet study protocol. Open
Introduction A major obstacle in understanding the relationship between diet and non-communicable diseases (NCDs) lies in the subjectivity and the bias in traditional dietary intake assessment methods. Food diaries, 24-hour food recall int…
View article: MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics
MetSCORE: a molecular metric to evaluate the risk of metabolic syndrome based on serum NMR metabolomics Open
Background Metabolic syndrome (MetS) is a cluster of medical conditions and risk factors correlating with insulin resistance that increase the risk of developing cardiometabolic health problems. The specific criteria for diagnosing MetS va…
View article: Cross-Validation of Metabolic Phenotypes in SARS-CoV-2 Infected Subpopulations Using Targeted Liquid Chromatography–Mass Spectrometry (LC-MS)
Cross-Validation of Metabolic Phenotypes in SARS-CoV-2 Infected Subpopulations Using Targeted Liquid Chromatography–Mass Spectrometry (LC-MS) Open
To ensure biological validity in metabolic phenotyping, findings must be replicated in independent sample sets. Targeted workflows have long been heralded as ideal platforms for such validation due to their robust quantitative capability. …
View article: Effect of age and dietary habits on Red Blood Cell membrane fatty acids in a Southern Europe population (Basque Country)
Effect of age and dietary habits on Red Blood Cell membrane fatty acids in a Southern Europe population (Basque Country) Open
The levels of blood eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are very variable and, in general, low in most of the world population. In this study, the effects of age, sex, COVID-19, and dietary habits on the lipid profil…
View article: Integrative Plasma Metabolic and Lipidomic Modelling of SARS-CoV-2 Infection in Relation to Clinical Severity and Early Mortality Prediction
Integrative Plasma Metabolic and Lipidomic Modelling of SARS-CoV-2 Infection in Relation to Clinical Severity and Early Mortality Prediction Open
An integrative multi-modal metabolic phenotyping model was developed to assess the systemic plasma sequelae of SARS-CoV-2 (rRT-PCR positive) induced COVID-19 disease in patients with different respiratory severity levels. Plasma samples fr…
View article: Serum and Urine Metabolomic Profiling of Newly Diagnosed Treatment-Naïve Inflammatory Bowel Disease Patients
Serum and Urine Metabolomic Profiling of Newly Diagnosed Treatment-Naïve Inflammatory Bowel Disease Patients Open
Background and Aims Inflammatory bowel disease (IBD) is a prevalent chronic noncurable disease associated with profound metabolic changes. The discovery of novel molecular indicators for unraveling IBD etiopathogenesis and the diagnosis an…
View article: Urinary Metabolomic Profile of Youth at Risk of Chronic Kidney Disease in Nicaragua
Urinary Metabolomic Profile of Youth at Risk of Chronic Kidney Disease in Nicaragua Open
Key Points Urinary concentrations of glycine, a molecule associated with thermoregulation, were elevated among youth from a high-risk region for chronic kidney disease of non-traditional etiology (CKDnt). Urinary concentrations of pyruvate…
View article: Integrative Metabolic, Lipidomic and Lipoproteomic Modelling of SARS-CoV-2 Infections in Relation to Clinical Severity and Early Mortality Prediction
Integrative Metabolic, Lipidomic and Lipoproteomic Modelling of SARS-CoV-2 Infections in Relation to Clinical Severity and Early Mortality Prediction Open
An integrative multi-modal metabolic phenotyping model was developed to assess the systemic plasma sequelae of SARS-CoV-2 (rRT-PCR positive) induced COVID-19 disease in patients with different respiratory severity levels. Plasma samples fr…
View article: Metabolic Features of Increased Gut Permeability, Inflammation, and Altered Energy Metabolism Distinguish Agricultural Workers at Risk for Mesoamerican Nephropathy
Metabolic Features of Increased Gut Permeability, Inflammation, and Altered Energy Metabolism Distinguish Agricultural Workers at Risk for Mesoamerican Nephropathy Open
Mesoamerican nephropathy (MeN) is a form of chronic kidney disease found predominantly in young men in Mesoamerica. Strenuous agricultural labor is a consistent risk factor for MeN, but the pathophysiologic mechanism leading to disease is …
View article: Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19
Metabolomics as a powerful tool for diagnostic, pronostic and drug intervention analysis in COVID-19 Open
COVID-19 currently represents one of the major health challenges worldwide. Albeit its infectious character, with onset affectation mainly at the respiratory track, it is clear that the pathophysiology of COVID-19 has a systemic character,…
View article: An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study
An NMR-Based Model to Investigate the Metabolic Phenoreversion of COVID-19 Patients throughout a Longitudinal Study Open
After SARS-CoV-2 infection, the molecular phenoreversion of the immunological response and its associated metabolic dysregulation are required for a full recovery of the patient. This process is patient-dependent due to the manifold possib…
View article: A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants
A flow cytometry-based neutralization assay for simultaneous evaluation of blocking antibodies against SARS-CoV-2 variants Open
Vaccines against SARS-CoV-2 have alleviated infection rates, hospitalization and deaths associated with COVID-19. In order to monitor humoral immunity, several serology tests have been developed, but the recent emergence of variants of con…
View article: Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles
Metabolic subtypes of patients with NAFLD exhibit distinctive cardiovascular risk profiles Open
Background and Aims We previously identified subsets of patients with NAFLD with different metabolic phenotypes. Here we align metabolomic signatures with cardiovascular disease (CVD) and genetic risk factors. Approach and Results We analy…
View article: Direct low field J-edited diffusional proton NMR spectroscopic measurement of COVID-19 inflammatory biomarkers in human serum
Direct low field J-edited diffusional proton NMR spectroscopic measurement of COVID-19 inflammatory biomarkers in human serum Open
A JEDI NMR pulse experiment incorporating relaxation, diffusion and J-modulation peak editing was implemented at a low field (80 MHz) spectrometer system to quantify two recently discovered plasma markers of SARS-CoV-2 infection and genera…