Nigel S. Atkinson
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View article: The non-nuclear DifB NF-κB isoform affects courtship, circadian, and locomotor behavior in adult Drosophila melanogaster
The non-nuclear DifB NF-κB isoform affects courtship, circadian, and locomotor behavior in adult Drosophila melanogaster Open
The Drosophila Dif gene uses alternative messenger RNA (mRNA) processing to encode two different nuclear factor kappa Bs (NF-κBs). The DifA isoform is a canonical NF-κB transcription factor that is important for activation of the immune re…
View article: PPI-ID: Streamlining protein-protein interaction prediction through domain and SLiM mapping
PPI-ID: Streamlining protein-protein interaction prediction through domain and SLiM mapping Open
AlphaFold-Multimer models protein complexes and facilitates protein-protein interaction (PPI) prediction. Mapping of protein interaction domains and motifs onto the 3D structure can lend credence to the model and provide insight into the f…
View article: PPI-ID: Streamlining Protein-Protein Interaction Prediction through Domain and SLiM Mapping
PPI-ID: Streamlining Protein-Protein Interaction Prediction through Domain and SLiM Mapping Open
AlphaFold-Multimer models protein complexes and facilitates protein-protein interaction (PPI) prediction. Mapping of protein interaction domains and motifs onto the 3D structure can lend credence to the model and provide insight into the f…
View article: The Role of Toll and Nonnuclear NF-κB Signaling in the Response to Alcohol
The Role of Toll and Nonnuclear NF-κB Signaling in the Response to Alcohol Open
An understanding of neuroimmune signaling has become central to a description of how alcohol causes addiction and how it damages people with an AUD. It is well known that the neuroimmune system influences neural activity via changes in gen…
View article: Alcohol‐induced aggression in Drosophila
Alcohol‐induced aggression in Drosophila Open
Alcohol‐induced aggression is a destructive and widespread phenomenon associated with violence and sexual assault. However, little is understood concerning its mechanistic origin. We have developed a Drosophila melanogaster model to geneti…
View article: Alcohol-induced Aggression
Alcohol-induced Aggression Open
Intraspecies aggression is commonly focused on securing reproductive resources such as food, territory, and mates, and it is often males who do the fighting. In humans, individual acts of overt physical aggression seem maladaptive and prob…
View article: Alcohol potentiates a pheromone signal in flies
Alcohol potentiates a pheromone signal in flies Open
For decades, numerous researchers have documented the presence of the fruit fly or Drosophila melanogaster on alcohol-containing food sources. Although fruit flies are a common laboratory model organism of choice, there is relatively littl…
View article: Author response: Alcohol potentiates a pheromone signal in flies
Author response: Alcohol potentiates a pheromone signal in flies Open
Article Figures and data Abstract Introduction Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract For decades, numerous researchers have documented the presenc…
View article: F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol‐Induced Behaviors in Drosophila
F654A and K558Q Mutations in NMDA Receptor 1 Affect Ethanol‐Induced Behaviors in Drosophila Open
Background N‐methyl‐D‐aspartate (NMDA) receptors regulate synaptic plasticity and modulate a wide variety of behaviors. Mammalian NMDA receptors are inhibited by ethanol (EtOH) even at low concentrations. In mice, the F639A mutation in tra…
View article: Alcohol Increases Aggression in Flies
Alcohol Increases Aggression in Flies Open
Alcohol-induced aggression is a destructive and widespread phenomenon, but we understand very little about the mechanisms that produce this behavior. We found that two different alcohol exposures potentiate aggression in male flies. (1) A …
View article: Microbiota-dependent elevation of Alcohol Dehydrogenase in<i>Drosophila</i>is associated with changes in alcohol-induced hyperactivity and alcohol preference
Microbiota-dependent elevation of Alcohol Dehydrogenase in<i>Drosophila</i>is associated with changes in alcohol-induced hyperactivity and alcohol preference Open
Summary The gut microbiota impacts diverse aspects of host biology including metabolism, immunity, and behavior, but the scope of those effects and their underlying molecular mechanisms are poorly understood. To address these gaps, we used…
View article: Monitoring food preference in <i>Drosophila</i> by oligonucleotide tagging
Monitoring food preference in <i>Drosophila</i> by oligonucleotide tagging Open
Significance Quantifying the preference for particular foods is difficult in Drosophila because of the animal’s small meal size. It is common for fly feeding assays to induce or require starvation conditions. We have developed BARCODE, a m…
View article: Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP
Alcohol-Induced Neuroadaptation Is Orchestrated by the Histone Acetyltransferase CBP Open
Homeostatic neural adaptations to alcohol underlie the production of alcohol tolerance and the associated symptoms of withdrawal. These adaptations have been shown to persist for relatively long periods of time and are believed to be of ce…
View article: Immediate-early alcohol-responsive miRNA expression in <i>Drosophila</i>
Immediate-early alcohol-responsive miRNA expression in <i>Drosophila</i> Open
At the core of the changes characteristic of alcoholism are alterations in gene expression in the brain of the addicted individual. These changes are believed to underlie some of the neuroadaptations that promote compulsive drinking. Unfor…
View article: Alcohol resistance in <i>Drosophila</i> is modulated by the Toll innate immune pathway
Alcohol resistance in <i>Drosophila</i> is modulated by the Toll innate immune pathway Open
A growing body of evidence has shown that alcohol alters the activity of the innate immune system and that changes in innate immune system activity can influence alcohol‐related behaviors. Here, we show that the Toll innate immune signalin…
View article: Interchangeable Punishments During Aversive Conditioning in Drosophila
Interchangeable Punishments During Aversive Conditioning in Drosophila Open
Using Drosophila melanogaster larvae we asked whether distinct aversive stimuli have a common neural representation during associative learning. We tested the interchangeability of heat shock and electroshock punishments when used within a…
View article: Immediate-early alcohol-responsive miRNA expression in <i>Drosophila</i>
Immediate-early alcohol-responsive miRNA expression in <i>Drosophila</i> Open
At the core of the changes characteristic of alcoholism are alterations in gene expression in the brain of the addicted individual. These changes are believed to underlie some of the neuroadaptations that promote compulsive drinking. Unfor…
View article: A histone modification identifies a DNA element controlling<i>slo</i>BK channel gene expression in muscle
A histone modification identifies a DNA element controlling<i>slo</i>BK channel gene expression in muscle Open
The slo gene encodes the BK-type Ca(2+)-activated K(+) channels. In Drosophila, expression of slo is induced by organic solvent sedation (benzyl alcohol and ethanol), and this increase in neural slo expression contributes to the production…