Nigel Capps
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View article: CT coronary angiography in the lipid clinic: a pilot study and lipidologist survey
CT coronary angiography in the lipid clinic: a pilot study and lipidologist survey Open
Guidelines recommend considering coronary calcium score (CCS) in asymptomatic patients to aid risk stratification. However, calcification occurs late in atherosclerosis. Coronary CT angiography (CCTA) can detect non-calcific plaque and inf…
View article: Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): A retrospective cohort study of individuals with FH in UK primary care and the UK Simon Broome register, linked with national hospital records
Cardiovascular disease morbidity is associated with social deprivation in subjects with familial hypercholesterolaemia (FH): A retrospective cohort study of individuals with FH in UK primary care and the UK Simon Broome register, linked with national hospital records Open
Strikingly fewer individuals with FH are identified from lower socioeconomic groups, though the most deprived FH patients have the highest risk of CVD and mortality. In CPRD, this risk was largely explained by smoking and alcohol consumpti…
View article: Assessing opinion on lower LDL-cholesterol lowering, and the role of newer lipid-reducing treatment options
Assessing opinion on lower LDL-cholesterol lowering, and the role of newer lipid-reducing treatment options Open
While statins are the gold standard for lipid-lowering therapies, newer therapies, such as PCSK9 inhibitors, have also demonstrated low-density lipoprotein cholesterol (LDL-C) reduction, but with a similar or better safety profile. Conflic…
View article: 174 Ct coronary angiography significantly changes treatment targets versus coronary artery calcium scoring in high-risk dyslipidaemia patients
174 Ct coronary angiography significantly changes treatment targets versus coronary artery calcium scoring in high-risk dyslipidaemia patients Open
Introduction Dyslipidaemia accelerates atherosclerosis. Patients with genetic dyslipidaemias, Familial Hypercholesterolaemia (FH) being the most common, are at heightened risk of premature cardiovascular events. However, this risk is heter…
View article: Targeting dyslipidaemia to prevent cardiovascular disease
Targeting dyslipidaemia to prevent cardiovascular disease Open
Dyslipidaemia is a key risk factor for cardiovascular disease, and its identification and treatment is important for both primary and secondary prevention. This article discusses how to screen for dyslipidaemia and optimise lipid‐lowering …
View article: HEART UK statement on the management of homozygous familial hypercholesterolaemia in the United Kingdom
HEART UK statement on the management of homozygous familial hypercholesterolaemia in the United Kingdom Open
This consensus statement addresses the current three main modalities of treatment of homozygous familial hypercholesterolaemia (HoFH): pharmacotherapy, lipoprotein (Lp) apheresis and liver transplantation. HoFH may cause very premature ath…