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View article: Current Challenges in Hemostasis and Advances in Particle‐Assisted Styptic Devices
Current Challenges in Hemostasis and Advances in Particle‐Assisted Styptic Devices Open
Rapid and effective hemorrhage control is critical in trauma and surgical interventions, where uncontrolled bleeding remains a leading cause of preventable death. In response to this urgent clinical demand, the development of novel hemosta…
View article: DataDecide: How to Predict Best Pretraining Data with Small Experiments
DataDecide: How to Predict Best Pretraining Data with Small Experiments Open
Because large language models are expensive to pretrain on different datasets, using smaller-scale experiments to decide on data is crucial for reducing costs. Which benchmarks and methods of making decisions from observed performance at s…
View article: Explainable AI: definition and attributes of a good explanation for health AI
Explainable AI: definition and attributes of a good explanation for health AI Open
Proposals of artificial intelligence (AI) solutions based on more complex and accurate predictive models are becoming ubiquitous across many disciplines. As the complexity of these models increases, there is a tendency for transparency and…
View article: Counterfactual reasoning using causal Bayesian networks as a healthcare governance tool
Counterfactual reasoning using causal Bayesian networks as a healthcare governance tool Open
Useful lessons can be learned by assessing decisions after they are made. M&M review meetings are fruitful ground for counterfactual reasoning. The use of a clinical decision support tool that can assist clinicians in assessing counterfact…
View article: The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: the (UK-REBOA) multicentre RCT
The UK resuscitative endovascular balloon occlusion of the aorta in trauma patients with life-threatening torso haemorrhage: the (UK-REBOA) multicentre RCT Open
Background The most common cause of preventable death after injury is haemorrhage. Resuscitative endovascular balloon occlusion of the aorta is intended to provide earlier, temporary haemorrhage control, to facilitate transfer to an operat…
View article: Prehospital Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Exsanguinating Subdiaphragmatic Hemorrhage
Prehospital Partial Resuscitative Endovascular Balloon Occlusion of the Aorta for Exsanguinating Subdiaphragmatic Hemorrhage Open
Importance Hemorrhage is the most common cause of preventable death after injury. Most deaths occur early, in the prehospital phase of care. Objective To establish whether prehospital zone 1 (supraceliac) partial resuscitative endovascular…
View article: REPAIRS Delphi: A UK and Ireland Consensus Statement on the Management of Infected Arterial Pseudoaneurysms Secondary to Groin Injecting Drug Use
REPAIRS Delphi: A UK and Ireland Consensus Statement on the Management of Infected Arterial Pseudoaneurysms Secondary to Groin Injecting Drug Use Open
This comprehensive consensus statement provides a strong insight into the standard of care for these patients.
View article: O65: Extremity Trauma in the UK (UK): Vascular Interventions and Surgery in Trauma Audit (VISTA)
O65: Extremity Trauma in the UK (UK): Vascular Interventions and Surgery in Trauma Audit (VISTA) Open
Background Extremity injury is the commonest form of vascular trauma but currently there is no national surgical surveillance of operative management and amputation rates. Vascular injury impacts both the young and elderly, with time criti…
View article: Identification of major hemorrhage in trauma patients in the prehospital setting: diagnostic accuracy and impact on outcome
Identification of major hemorrhage in trauma patients in the prehospital setting: diagnostic accuracy and impact on outcome Open
Background Hemorrhage is the most common cause of potentially preventable death after injury. Early identification of patients with major hemorrhage (MH) is important as treatments are time-critical. However, diagnosis can be difficult, ev…
View article: Updating and recalibrating causal probabilistic models on a new target population
Updating and recalibrating causal probabilistic models on a new target population Open
The methodology proposed in this study is important for developing credible models that can demonstrate a good predictive performance when applied to a target population. Another advantage of the proposed methodology is that it is not limi…
View article: Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage
Emergency Department Resuscitative Endovascular Balloon Occlusion of the Aorta in Trauma Patients With Exsanguinating Hemorrhage Open
Importance Bleeding is the most common cause of preventable death after trauma. Objective To determine the effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) when used in the emergency department along with …
View article: Understanding pre-hospital blood transfusion decision-making for injured patients: an interview study
Understanding pre-hospital blood transfusion decision-making for injured patients: an interview study Open
Background Blood transfusion for bleeding trauma patients is a promising pre-hospital intervention with potential to improve outcomes. However, it is not yet clear which patients may benefit from pre-hospital transfusions. The aim of this …
View article: FTP1.7 Critical decision analysis of pre-hospital major haemorrhage protocol activation
FTP1.7 Critical decision analysis of pre-hospital major haemorrhage protocol activation Open
Aims Major haemorrhage protocol activation (MHPA) facilitates immediate blood product availability and institutional capacity readiness for bleeding trauma patients. MHPA is a difficult decision pre-hospital, where two thirds of MHPAs occu…
View article: Methods used to evaluate usability of mobile clinical decision support systems for healthcare emergencies: a systematic review and qualitative synthesis
Methods used to evaluate usability of mobile clinical decision support systems for healthcare emergencies: a systematic review and qualitative synthesis Open
Objective The aim of this study was to determine the methods and metrics used to evaluate the usability of mobile application Clinical Decision Support Systems (CDSSs) used in healthcare emergencies. Secondary aims were to describe the cha…
View article: Diagnostic accuracy of clinical examination to identify life- and limb-threatening injuries in trauma patients
Diagnostic accuracy of clinical examination to identify life- and limb-threatening injuries in trauma patients Open
Background Timely and accurate identification of life- and limb-threatening injuries (LLTIs) is a fundamental objective of trauma care that directly informs triage and treatment decisions. However, the diagnostic accuracy of clinical exami…
View article: The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial)
The effectiveness and cost-effectiveness of resuscitative endovascular balloon occlusion of the aorta (REBOA) for trauma patients with uncontrolled torso haemorrhage: study protocol for a randomised clinical trial (the UK-REBOA trial) Open
Background Haemorrhage is the most common cause of preventable death after injury. REBOA is a novel technique whereby a percutaneously inserted balloon is deployed in the aorta, providing a relatively quick means of temporarily controlling…
View article: The UK Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) Randomized Clinical Trial (the UK-REBOA trial): Study Protocol
The UK Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) Randomized Clinical Trial (the UK-REBOA trial): Study Protocol Open
BackgroundHaemorrhage is the most common cause of preventable death after injury. REBOA is a novel technique whereby a percutaneously inserted balloon is deployed in the aorta, providing a relatively quick means of temporarily controlling …
View article: Early Identification of Trauma-induced Coagulopathy: Development and Validation of a Multivariable Risk Prediction Model.
Early Identification of Trauma-induced Coagulopathy: Development and Validation of a Multivariable Risk Prediction Model. Open
A BN (http://www.traumamodels.com) can accurately predict the risk of TIC in an individual patient from standard admission clinical variables. This information may support early, accurate, and efficient activation of hemostatic resuscitati…
View article: Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial
Pharmacokinetics of intramuscular tranexamic acid in bleeding trauma patients: a clinical trial Open
2019-000898-23 (EudraCT); NCT03875937 (ClinicalTrials.gov).
View article: Predicting the Outcome of Limb Revascularization in Patients With Lower-extremity Arterial Trauma
Predicting the Outcome of Limb Revascularization in Patients With Lower-extremity Arterial Trauma Open
Objectives: Estimating the likely success of limb revascularization in patients with lower-extremity arterial trauma is central to decisions between attempting limb salvage and amputation. However, the projected outcome is often unclear at…
View article: An Incremental Explanation of Inference in Hybrid Bayesian Networks for Increasing Model Trustworthiness and Supporting Clinical Decision Making
An Incremental Explanation of Inference in Hybrid Bayesian Networks for Increasing Model Trustworthiness and Supporting Clinical Decision Making Open
Various AI models are increasingly being considered as part of clinical decision-support tools. However, the trustworthiness of such models is rarely considered. Clinicians are more likely to use a model if they can understand and trust it…