Nigel Turner
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View article: Epoxidation-enhanced charge-switch derivatization for rapid profiling of monounsaturated fatty acid isomers
Epoxidation-enhanced charge-switch derivatization for rapid profiling of monounsaturated fatty acid isomers Open
Structural isomerism in monounsaturated fatty acids (MUFAs) presents a persistent challenge in lipidomics due to limited chromatographic resolution and indistinguishable mass spectral profiles. Moreover, many methods that overcome these li…
View article: CD38 mediates nicotinamide mononucleotide base exchange to yield nicotinic acid mononucleotide
CD38 mediates nicotinamide mononucleotide base exchange to yield nicotinic acid mononucleotide Open
Nicotinamide mononucleotide (NMN) is a widely investigated metabolic precursor to the prominent enzyme cofactor NAD+, where it is assumed that delivery of this compound results in its direct incorporation into NAD+via the canonical salvage…
View article: Targeting <i>de novo</i> lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma
Targeting <i>de novo</i> lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease with few treatment options and poor survivability. In this work we sought to characterise metabolic adaptations to gemcitabine (GEMC)-based chemotherapy exposure to dis…
View article: Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome
Fertility protection during chemotherapy treatment by boosting the NAD(P)+ metabolome Open
Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to maintain ovarian function are urgently needed. Given the…
View article: CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN)
CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN) Open
Nicotinamide mononucleotide (NMN) is a widely investigated metabolic precursor to the prominent redox cofactor nicotinamide adenine dinucleotide (NAD + ), where it is assumed that delivery of this compound results in its direct incorporati…
View article: Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism
Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism Open
In recent decades, the role of tumor biomechanics on cancer cell behavior at the primary site has been increasingly appreciated. However, the effect of primary tumor biomechanics on the latter stages of the metastatic cascade, such as meta…
View article: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction Open
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in …
View article: Author response: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Author response: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction Open
Full text Figures and data Peer review Side by side Abstract eLife assessment Introduction Results Discussion Methods Data availability References Article and author information Metrics Abstract Age-related muscle wasting and dysfunction r…
View article: Reviewer #1 (Public Review): Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Reviewer #1 (Public Review): Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction Open
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in …
View article: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction Open
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in …
View article: Reviewer #2 (Public Review): Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Reviewer #2 (Public Review): Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction Open
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in …
View article: Author Response: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction
Author Response: Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction Open
Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in …
View article: Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice
Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice Open
Semaglutide is an anti-diabetes and weight loss drug that decreases food intake, slows gastric emptying, and increases insulin secretion. Patients begin treatment with low-dose semaglutide and increase dosage over time as efficacy plateaus…
View article: Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase
Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase Open
‘Inner mitochondrial membrane peptidase 2 like’ (IMMP2L) is a nuclear-encoded mitochondrial peptidase that has been conserved through evolutionary history, as has its target enzyme, ‘mitochondrial glycerol phosphate dehydrogenase 2′ (GPD2)…
View article: Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS
Proteomic analysis shows decreased type I fibers and ectopic fat accumulation in skeletal muscle from women with PCOS Open
Background: Polycystic ovary syndrome’s (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders. Gene expression analyses in adipose tissue and skeletal muscle reveal dysregulated metabolic pathways…
View article: Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
Mitochondrial electron transport chain, ceramide, and coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Open
Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly…
View article: IMMP2L Peptidase Enhances the Structure and Function of Mitochondrial GPD2 Dehydrogenase.
IMMP2L Peptidase Enhances the Structure and Function of Mitochondrial GPD2 Dehydrogenase. Open
‘Inner mitochondrial membrane peptidase 2 like’ (IMMP2L) is a nuclear encoded mitochondrial peptidase that has been conserved through evolutionary history as has its target enzyme ‘mitochondrial glycerol phosphate dehydrogenase 2’ (GPD2). …
View article: Author Response: Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS
Author Response: Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS Open
Polycystic ovary syndrome’s (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders in women. Gene expression analyses in adipose tissue and skeletal muscle reveal dysregulated metabolic pathways in…
View article: Reviewer #2 (Public Review): Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS
Reviewer #2 (Public Review): Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS Open
Polycystic ovary syndrome’s (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders in women. Gene expression analyses in adipose tissue and skeletal muscle reveal dysregulated metabolic pathways in…
View article: Reviewer #1 (Public Review): Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS
Reviewer #1 (Public Review): Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS Open
Polycystic ovary syndrome's (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders in women. Gene expression analyses in adipose tissue and skeletal muscle reveal dysregulated metabolic pathways in…
View article: Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS
Type I fiber decrease and ectopic fat accumulation in skeletal muscle from women with PCOS Open
Polycystic ovary syndrome’s (PCOS) main feature is hyperandrogenism, which is linked to a higher risk of metabolic disorders in women. Gene expression analyses in adipose tissue and skeletal muscle reveal dysregulated metabolic pathways in…
View article: #389 : Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice
#389 : Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice Open
Background and Aims: Chemotherapy induced ovarian failure and infertility is an important concern in female cancer patients of reproductive age or younger, and non-invasive, pharmacological approaches to prevent chemotherapy induced infert…
View article: <scp>SIRT2</scp> transgenic over‐expression does not impact lifespan in mice
<span>SIRT2</span> transgenic over‐expression does not impact lifespan in mice Open
The NAD + ‐dependent deacylase family of sirtuin enzymes have been implicated in biological ageing, late‐life health and overall lifespan, though of these members, a role for sirtuin‐2 (SIRT2) is less clear. Transgenic overexpression of SI…
View article: Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Open
Summary Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remai…
View article: Reviewer #2 (Public Review): Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
Reviewer #2 (Public Review): Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Open
Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly…
View article: Reviewer #1 (Public Review): Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
Reviewer #1 (Public Review): Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Open
Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly…
View article: Author Response: Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle
Author Response: Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle Open
Insulin resistance (IR) is a complex metabolic disorder that underlies several human diseases, including type 2 diabetes and cardiovascular disease. Despite extensive research, the precise mechanisms underlying IR development remain poorly…