Nihil Abraham
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View article: First Reported Case of Infection Involving a Leadless Atrial Pacemaker
First Reported Case of Infection Involving a Leadless Atrial Pacemaker Open
Leadless pacemakers can still develop infections. Percutaneous aspiration-guided removal is a feasible management option. Prompt recognition and intervention are essential.
View article: Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism
Lysosomal LRRC8 complex impacts lysosomal pH, morphology, and systemic glucose metabolism Open
The lysosome integrates anabolic signaling and nutrient sensing to regulate intracellular growth pathways. The leucine-rich repeat–containing 8 (LRRC8) channel complex forms a lysosomal anion channel and regulates PI3K-AKT-mTOR signaling, …
View article: LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis
LRRC8 complexes are ATP release channels that regulate platelet activation and arterial thrombosis Open
Platelet shape and volume changes are early mechanical events contributing to platelet activation and thrombosis. Here, we identify single-nucleotide polymorphisms in leucine-rich repeat–containing 8 (LRRC8) protein subunits that form the …
View article: LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis
LRRC8 complexes are adenosine nucleotide release channels regulating platelet activation and arterial thrombosis Open
Platelet shape and volume changes are early mechanical events contributing to platelet activation and thrombosis. Here, we identify single-nucleotide polymorphisms in Leucine-Rich Repeat Containing 8 (LRRC8) protein subunits that form the …
View article: Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism
Lysosomal LRRC8 complex regulates lysosomal pH, morphology and systemic glucose metabolism Open
The lysosome integrates anabolic signalling and nutrient-sensing to regulate intracellular growth pathways. The leucine-rich repeat containing 8 (LRRC8) channel complex forms a lysosomal anion channel and regulates PI3K-AKT-mTOR signalling…