Niina Lietzén
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View article: Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes
Serum APOC1 levels are decreased in young autoantibody positive children who rapidly progress to type 1 diabetes Open
Better understanding of the early events in the development of type 1 diabetes is needed to improve prediction and monitoring of the disease progression during the substantially heterogeneous presymptomatic period of the beta cell damaging…
View article: Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory
Targeted serum proteomics of longitudinal samples from newly diagnosed youth with type 1 diabetes distinguishes markers of disease and C-peptide trajectory Open
View article: Umbilical cord blood DNA methylation in children who later develop type 1 diabetes
Umbilical cord blood DNA methylation in children who later develop type 1 diabetes Open
View article: Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples
Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples Open
DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, such as maternal…
View article: Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples
Permutation-based significance analysis reduces the type 1 error rate in bisulphite sequencing data analysis of human umbilical cord blood samples Open
DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, such as maternal…
View article: Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples
Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples Open
DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, such as maternal…
View article: Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells
Persistent coxsackievirus B1 infection triggers extensive changes in the transcriptome of human pancreatic ductal cells Open
View article: Umbilical Cord Blood DNA Methylation in Children Who Later Develop Type 1 Diabetes
Umbilical Cord Blood DNA Methylation in Children Who Later Develop Type 1 Diabetes Open
Distinct DNA methylation patterns have recently been observed to precede type 1 diabetes in whole blood collected from young children. Our aim was to determine, whether perinatal DNA methylation could be associated with later progression t…
View article: Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples
Permutation-based significance analysis reduces the type 1 error rate in bisulfite sequencing data analysis of human umbilical cord blood samples Open
Background DNA methylation patterns are largely established in-utero and might mediate the impacts of in-utero conditions on later health outcomes. Associations between perinatal DNA methylation marks and pregnancy-related variables, such …
View article: Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells
Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells Open
The group B Coxsackieviruses (CVB), belonging to the Enterovirus genus, can establish persistent infections in human cells. These persistent infections have been linked to chronic diseases including type 1 diabetes. Still, the outcomes of …
View article: Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood
Characterization and non-parametric modeling of the developing serum proteome during infancy and early childhood Open
Children develop rapidly during the first years of life, and understanding the sources and associated levels of variation in the serum proteome is important when using serum proteins as markers for childhood diseases. The aim of this study…