Nikesh Kunder
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View article: Genome sequences of fifteen soil bacteria isolated from the Dallas-Fort Worth Area, United States
Genome sequences of fifteen soil bacteria isolated from the Dallas-Fort Worth Area, United States Open
Soil is a rich source of diverse bacteria that produce useful metabolites, including antibiotics. Here, we report the genomes of 15 bacterial isolates cultured from soils from the Dallas-Ft. Worth metroplex area of the United States, inclu…
View article: In vivo antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity
In vivo antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity Open
Leukocytes migrate through the blood and extravasate into organs to surveil the host for infection or cancer. Recently, we demonstrated that intravenous (IV) anti-CD45.2 antibody labeling allowed for precise tracking of leukocyte migration…
View article: <i>In vivo</i>antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity
<i>In vivo</i>antibody labeling route and fluorophore dictate labeling efficiency, sensitivity, and longevity Open
Leukocytes migrate through the blood and extravasate into organs to surveil the host for infection or cancer. Recently, we demonstrated that intravenous (IV) anti-CD45.2 antibody labeling allowed for precise tracking of leukocyte migration…
View article: Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer
Longitudinal Intravascular Antibody Labeling Identified Regulatory T Cell Recruitment as a Therapeutic Target in a Mouse Model of Lung Cancer Open
Anticancer immunity is predicated on leukocyte migration into tumors. Once recruited, leukocytes undergo substantial reprogramming to adapt to the tumor microenvironment. A major challenge in the field is distinguishing recently recruited …
View article: Inhibition of Nonsense-Mediated Decay Induces Nociceptive Sensitization through Activation of the Integrated Stress Response
Inhibition of Nonsense-Mediated Decay Induces Nociceptive Sensitization through Activation of the Integrated Stress Response Open
RNA stability is meticulously controlled. Here, we sought to determine whether an essential post-transcriptional regulatory mechanism plays a role in pain. Nonsense-mediated decay (NMD) safeguards against translation of mRNAs that harbor p…
View article: The RNA-Binding Protein HuR Is Integral to the Function of Nociceptors in Mice and Humans
The RNA-Binding Protein HuR Is Integral to the Function of Nociceptors in Mice and Humans Open
HuR is an RNA-binding protein implicated in RNA processing, stability, and translation. Previously, we examined protein synthesis in dorsal root ganglion (DRG) neurons treated with inflammatory mediators using ribosome profiling. We found …
View article: Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance in sensory neurons
Functionally distinct roles for eEF2K in the control of ribosome availability and p-body abundance in sensory neurons Open
Processing bodies (p-bodies) are a prototypical phase-separated RNA-containing granule. Their abundance is highly dynamic and has been linked to translation. Yet, the molecular mechanisms responsible for coordinate control of the two proce…
View article: A role for translational regulation by S6 kinase and a downstream target in inflammatory pain
A role for translational regulation by S6 kinase and a downstream target in inflammatory pain Open
Background and Purpose Translational controls pervade neurobiology. Nociceptors play an integral role in the detection and propagation of pain signals. Nociceptors can undergo persistent changes in their intrinsic excitability. Pharmacolog…
View article: Intercellular Arc Signaling Regulates Vasodilation
Intercellular Arc Signaling Regulates Vasodilation Open
Injury responses require communication between different cell types in the skin. Sensory neurons contribute to inflammation and can secrete signaling molecules that affect non-neuronal cells. Despite the pervasive role of translational reg…
View article: A peptide encoded within a 5′ untranslated region promotes pain sensitization in mice
A peptide encoded within a 5′ untranslated region promotes pain sensitization in mice Open
Translational regulation permeates neuronal function. Nociceptors are sensory neurons responsible for the detection of harmful stimuli. Changes in their activity, termed plasticity, are intimately linked to the persistence of pain. Althoug…
View article: Intercellular Arc signaling regulates vasodilation
Intercellular Arc signaling regulates vasodilation Open
Injury responses require communication between different cell types in the skin. Sensory neurons contribute to inflammation and can secrete signaling molecules that affect non-neuronal cells. Despite the pervasive role of translational reg…
View article: Issue Information
Issue Information Open
Cyto-Chex® BCT is Also availableStreck Cell Preservative™ is an easy-to-use liquid preservative that maintains cellular antigen expression, including cluster of differentiation (CD) markers of biological samples for analysis by flow cytome…
View article: Evaluation of new markers for minimal residual disease monitoring in B‐cell precursor acute lymphoblastic leukemia: CD73 and CD86 are the most relevant new markers to increase the efficacy of MRD 2016; 00B: 000–000
Evaluation of new markers for minimal residual disease monitoring in B‐cell precursor acute lymphoblastic leukemia: CD73 and CD86 are the most relevant new markers to increase the efficacy of MRD 2016; 00B: 000–000 Open
Background Multiparametric flow cytometry (MFC) is a popular technique for minimal residual disease (MRD) analysis. However, its applicability is still limited to 90% of B‐cell precursor acute lymphoblastic leukemia (BCPALL) due to two maj…