Niketa Patel
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View article: The Human Omental Adipose Depot Mitigates Inflammation, Immune Response, and Oxidative Stress Pathways in Response to Injury via Its Secretome
The Human Omental Adipose Depot Mitigates Inflammation, Immune Response, and Oxidative Stress Pathways in Response to Injury via Its Secretome Open
Human intraperitoneal omental adipose tissue, part of the visceral adipose depots, surrounds the abdominal organs and has functions distinct from the subcutaneous adipose depots. In the clinical setting, it is observed that the omentum is …
View article: Knowledge and Attitude towards Sports Injury Prevention and Management among Sports Playing College Students: A Cross-sectional Study
Knowledge and Attitude towards Sports Injury Prevention and Management among Sports Playing College Students: A Cross-sectional Study Open
Introduction: Sports is an emerging field among young people and has gained popularity worldwide. Consequently, the prevalence of sports-related injuries has increased day by day. To address this issue, all types of studies have been condu…
View article: Visualizing the Global Landscape of Post-transplant Acute Lung Rejection
Visualizing the Global Landscape of Post-transplant Acute Lung Rejection Open
View article: Human Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI
Human Adipose-Stem-Cell-Derived Small Extracellular Vesicles Modulate Behavior and Glial Cells in Young and Aged Mice Following TBI Open
Traumatic brain injury (TBI) is a major cause of long-term neurological impairment, with aging amplifying vulnerability and worsening recovery. Older individuals face greater cognitive and motor deficits post-TBI and respond less effective…
View article: Promotion of recovery from Traumatic Brain Injury (TBI) by Granulocyte Colony-Stimulating Factor (G-CSF) treatment requires cannabinoid receptor type 2 activity
Promotion of recovery from Traumatic Brain Injury (TBI) by Granulocyte Colony-Stimulating Factor (G-CSF) treatment requires cannabinoid receptor type 2 activity Open
Granulocyte colony-stimulating factor (G-CSF) has the capacity to enhance brain repair following various injuries to brain. G-CSF treatment after TBI in rodents has been reported to promote brain repair, hippocampal neurogenesis, and behav…
View article: Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor
Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor Open
Stimulator of interferon genes (STING) is a transmembrane endoplasmic reticulum (ER) resident protein involved in innate immunity. STING activation occurs by binding of cyclic guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate…
View article: Weight-Bearing Approaches After Neck of Femur Fractures: A Narrative Review of Evidence and Outcomes
Weight-Bearing Approaches After Neck of Femur Fractures: A Narrative Review of Evidence and Outcomes Open
Neck of femur fractures, a prevalent injury among the elderly, significantly impair mobility, independence, and quality of life. The timing and extent of weight bearing post-surgery are critical to recovery, yet clinical practices vary wid…
View article: Abstract 1105 Adipose stem cells from the human omentum secrete exosomes to promote healing by regulating apoptosis and immune response pathways in vivo
Abstract 1105 Adipose stem cells from the human omentum secrete exosomes to promote healing by regulating apoptosis and immune response pathways in vivo Open
View article: High Glucose-induced transcriptomic changes in human trabecular meshwork cells
High Glucose-induced transcriptomic changes in human trabecular meshwork cells Open
View article: NPC86 Increases LncRNA Gas5 In Vivo to Improve Insulin Sensitivity and Metabolic Function in Diet-Induced Obese Diabetic Mouse Model
NPC86 Increases LncRNA Gas5 In Vivo to Improve Insulin Sensitivity and Metabolic Function in Diet-Induced Obese Diabetic Mouse Model Open
In the United States, an estimated 38 million individuals (10% of the population) have type 2 diabetes mellitus (T2D), while approximately 97.6 million adults (38%) have prediabetes. Long noncoding RNAs (lncRNAs) are critical regulators of…
View article: lncRNAs GAS5 and MALAT1 Contained in Human Adipose Stem Cell (hASC)-Derived Exosomes Drive the Cell-Free Repair and Regeneration of Wounds In Vivo
lncRNAs GAS5 and MALAT1 Contained in Human Adipose Stem Cell (hASC)-Derived Exosomes Drive the Cell-Free Repair and Regeneration of Wounds In Vivo Open
Wound healing progresses through four phases: hemostasis, inflammation, proliferation, and remodeling. Wounds may become chronic if this process is disrupted. The use of small extracellular vesicle (sEV; EVs < 200 nm) exosomes (exo; ~40–12…
View article: Hip Abductor Muscle Strength In Patients With Avascular Necrosis of The Femoral Head
Hip Abductor Muscle Strength In Patients With Avascular Necrosis of The Femoral Head Open
Background: Studies have reported that hip abductor muscle weakness is a common finding post-surgery in patients suffering from avascular necrosis of the femoral head. Hence, our main study aimed to estimate the hip abductor muscle strengt…
View article: Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor
Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor Open
Stimulator of interferon genes (STING) is a transmembrane endoplasmic reticulum (ER) resident protein involved in innate immunity. STING activation occurs by binding of cyclic guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate…
View article: Lyophilized Small Extracellular Vesicles (sEVs) Derived from Human Adipose Stem Cells Maintain Efficacy to Promote Healing in Neuronal Injuries
Lyophilized Small Extracellular Vesicles (sEVs) Derived from Human Adipose Stem Cells Maintain Efficacy to Promote Healing in Neuronal Injuries Open
Background: Traumatic brain injury (TBI) occurs in individuals of all ages, predominantly during sports, accidents, and in active military service members. Chronic consequences of TBI include declined cognitive and motor function, dementia…
View article: High Glucose-Induced Transcriptomic Changes in Human Trabecular Meshwork Cells
High Glucose-Induced Transcriptomic Changes in Human Trabecular Meshwork Cells Open
View article: Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor
Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor Open
Stimulator of interferon genes (STING) is a transmembrane endoplasmic reticulum (ER) resident protein involved in innate immunity. STING activation occurs by binding of cyclic guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate…
View article: Small Molecule Inhibitor of Protein Kinase C DeltaI (PKCδI) Decreases Inflammatory Pathways and Gene Expression and Improves Metabolic Function in Diet-Induced Obese Mouse Model
Small Molecule Inhibitor of Protein Kinase C DeltaI (PKCδI) Decreases Inflammatory Pathways and Gene Expression and Improves Metabolic Function in Diet-Induced Obese Mouse Model Open
Obesity promotes metabolic diseases such as type 2 diabetes and cardiovascular disease. PKCδI is a serine/threonine kinase which regulates cell growth, differentiation, and survival. Caspase-3 cleavage of PKCδI releases the C-terminal cata…
View article: Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor
Discovery of Clonixeril as a Sub-Femtomolar Modulator of the Human STING Receptor Open
Stimulator of interferon genes (STING) is a transmembrane endoplasmic reticulum (ER) resident protein involved in innate immunity. STING activation occurs by binding of cyclic guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate…
View article: 7877 Adipose Depot Differences In Regenerative Properties Of Exosomes Derived From Human Adipose Stem Cells
7877 Adipose Depot Differences In Regenerative Properties Of Exosomes Derived From Human Adipose Stem Cells Open
Disclosure: M.A. Krause-Hauch: None. R. Patel: None. B. Osborne: None. P. Albear: None. N.A. Patel: None. Many patients struggle with chronic recalcitrant wounds that are the result of delayed healing. Underlying inflammation is one major …
View article: Hip Abductor Muscle Strength Recovery: A Comparison Between Joint Replacement Surgery and Internal Fixation Surgery
Hip Abductor Muscle Strength Recovery: A Comparison Between Joint Replacement Surgery and Internal Fixation Surgery Open
Introduction Proximal femoral fractures are common fractures of the hip that are considered a major healthcare concern globally; these include subtrochanteric, intertrochanteric, and the neck of the femur fractures. Internal fixation surge…
View article: Exploring the Feasibility of the Use of Sphygmomanometer for Assessing Hip Abductor Muscle Strength in Avascular Necrosis Patients – A Pilot Study
Exploring the Feasibility of the Use of Sphygmomanometer for Assessing Hip Abductor Muscle Strength in Avascular Necrosis Patients – A Pilot Study Open
Background Avascular necrosis of the femoral head is a degenerative disorder brought on by a disruption in the blood supply to the subchondral region, which in turn causes the disintegration of cells and eventual destruction of the femoral…
View article: Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans
Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans Open
More than 75% of traumatic brain injuries (TBIs) are mild (mTBI) and military service members often experience repeated combat-related mTBI. The chronic comorbidities concomitant with repetitive mTBI (rmTBI) include depression, post-trauma…
View article: Female and male obese Zucker rats display differential inflammatory mediator and long non-coding RNA profiles
Female and male obese Zucker rats display differential inflammatory mediator and long non-coding RNA profiles Open
View article: FRI027 Regulation Of A Novel Sortilin Splice Variant Expression In Human Diabetic Adipocytes By GLP-1 To Maintain Glucose Homeostasis
FRI027 Regulation Of A Novel Sortilin Splice Variant Expression In Human Diabetic Adipocytes By GLP-1 To Maintain Glucose Homeostasis Open
Disclosure: N.A. Patel: None. R.S. Patel: None. A. Liu: None. Type 2 diabetes mellitus (T2DM) is a chronic and progressive metabolic disease with no cure. 37.3 million Americans have T2DM as of 2021 and 96 million (1 in 3) are prediabetic.…
View article: Regulation of Human Sortilin Alternative Splicing by Glucagon-like Peptide-1 (GLP1) in Adipocytes
Regulation of Human Sortilin Alternative Splicing by Glucagon-like Peptide-1 (GLP1) in Adipocytes Open
Type 2 diabetes mellitus is a chronic metabolic disease with no cure. Adipose tissue is a major site of systemic insulin resistance. Sortilin is a central component of the glucose transporter -Glut4 storage vesicles (GSV) which translocate…
View article: Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function
Ceramide synthesis regulates biogenesis and packaging of exosomal MALAT1 from adipose derived stem cells, increases dermal fibroblast migration and mitochondrial function Open
View article: Comparison of post-operative hip abductor muscle strength and functional outcome between dynamic hip screw and proximal femoral nail in intertrochanteric fracture
Comparison of post-operative hip abductor muscle strength and functional outcome between dynamic hip screw and proximal femoral nail in intertrochanteric fracture Open
Extra capsular intertrochanteric femur fractures occur between femoral neck and lesser trochanter of the femur.However, this study aims to study the influence of restoration of femoral offset in relation to the strength of the hip abductor…
View article: Approaches for Total Hip Arthroplasty: A Systematic Review
Approaches for Total Hip Arthroplasty: A Systematic Review Open
These surgical procedures have their own challenges, limitations, and success rate. The choice of surgical approach will depend on many factors including the surgeon's choice, type of pathology, bone stock, age of the patient, and experien…
View article: Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model
Small molecule targeting long noncoding RNA GAS5 administered intranasally improves neuronal insulin signaling and decreases neuroinflammation in an aged mouse model Open
View article: Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules
Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules Open
Excessive dietary intake of fat results in its storage in white adipose tissue (WAT). Energy expenditure through lipid oxidation occurs in brown adipose tissue (BAT). Certain WAT depots can undergo a change termed beiging where markers tha…