Nikhat J. Siddiqi
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View article: Comparative Mechanistic Insights into Quercetin-Loaded Selenium Nanoparticles and Cisplatin in HCT116 Cells
Comparative Mechanistic Insights into Quercetin-Loaded Selenium Nanoparticles and Cisplatin in HCT116 Cells Open
View article: Protective Role of Gallic Acid Against Corticosterone-Induced Hepatic Toxicity: Modulation of Oxidative Stress and Inflammatory Pathways in Wistar Rats
Protective Role of Gallic Acid Against Corticosterone-Induced Hepatic Toxicity: Modulation of Oxidative Stress and Inflammatory Pathways in Wistar Rats Open
Corticosterone (CORT), a key stress hormone, is vital for energy balance, but prolonged exposure causes hyperglycemia, obesity, and hepatotoxicity. Gallic acid (GA), a natural polyphenol with antioxidant and anti-inflammatory properties, w…
View article: Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2
Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2 Open
Introduction Herpes Simplex Virus type 2 or HSV-2 is a major cause of genital herpes, contributing to increased susceptibility to HIV, encephalitis, and other severe complications. Despite the availability of antiviral therapies such as ac…
View article: Apoptosis, DNA damage, and cell cycle arrest: The anticancer mechanisms of quercetin in human cervix epithelioid carcinoma cells
Apoptosis, DNA damage, and cell cycle arrest: The anticancer mechanisms of quercetin in human cervix epithelioid carcinoma cells Open
Objectives The objectives of the study are to investigate the anti-cancer properties of quercetin, a widely distributed phytochemical, and assess its potential as a chemopreventive and therapeutic agent for cervical cell carcinoma. Methods…
View article: Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles
Molecular Mechanisms of Phthalate-Induced Hepatic Injury and Amelioration by Plant-Based Principles Open
Phthalates are the emerging environmental toxicants derived from phthalic acid and its constituents, which are moderately present in plastics and many personal care products. Phthalate exposure occurs through various environmental factors,…
View article: Harnessing miRNA dynamics in HIV-1-infected macrophages: Unveiling new targeted therapeutics using systems biology
Harnessing miRNA dynamics in HIV-1-infected macrophages: Unveiling new targeted therapeutics using systems biology Open
View article: Phytochemical profiling, antioxidant potential and cytotoxic activity of <i>Sargassum prismaticum</i> extracts: implications for therapeutic applications
Phytochemical profiling, antioxidant potential and cytotoxic activity of <i>Sargassum prismaticum</i> extracts: implications for therapeutic applications Open
Seaweeds are sources of bioactive compounds with medicinal properties, which make them attractive candidates for natural therapeutic agents. Marine brown algae are known to possess anti-inflammatory, hepatoprotective, anticancer properties…
View article: Cancer-Preventive Activity of Argemone mexicana Linn Leaves and Its Effect on TNF-α and NF-κB Signalling
Cancer-Preventive Activity of Argemone mexicana Linn Leaves and Its Effect on TNF-α and NF-κB Signalling Open
Skin cancer is the 5th most common cancer in Western countries with a surge in case occurrences making it a global burden on healthcare systems. The present study aims to evaluate the cancer-preventive activity of an ethanolic extract of A…
View article: Cancer-Preventive Activity of Argemone mexicana Linn Leaves and Interpretation of Its Orchestral Effect on TNF-α and NF-kB Signaling Modulation in DMBA/TPA Induced Skin Cancer Mice Model
Cancer-Preventive Activity of Argemone mexicana Linn Leaves and Interpretation of Its Orchestral Effect on TNF-α and NF-kB Signaling Modulation in DMBA/TPA Induced Skin Cancer Mice Model Open
Introduction: Skin cancer is the 5th most common cancers in western countries with surge in the cases of occurrence with the passing time making it a global burden on health care system. In this present study, the cancer preventive activit…
View article: Antioxidative effect of Aloe vera against malathion induced neurotoxic response in Wistar rats
Antioxidative effect of Aloe vera against malathion induced neurotoxic response in Wistar rats Open
Insight about the impact of malathion on human physiology is still a challenge in environmental health. The present work was focused on the neurotoxic effects of malathion followed by impact of Aloe vera, if any, which is not known. The ma…
View article: Analysis of Biochemical and Antimicrobial Properties of Bioactive Molecules of Argemone mexicana
Analysis of Biochemical and Antimicrobial Properties of Bioactive Molecules of Argemone mexicana Open
This study identified phytochemicals in Argemone mexicana (A. mexicana) extracts that are responsible for its medicinal properties, and the best solvent for their extraction. The extracts of the stem, leaves, flowers, and fruits of A. mexi…
View article: Elucidation of the Anticancer Mechanism of Durian Fruit (Durio zibethinus) Pulp Extract in Human Leukemia (HL-60) Cancer Cells
Elucidation of the Anticancer Mechanism of Durian Fruit (Durio zibethinus) Pulp Extract in Human Leukemia (HL-60) Cancer Cells Open
Durian (Durio zibethinus L.) grows widely in Southeast Asia. The pulp of the durian fruit contains carbohydrates, proteins, lipids, fibers, various vitamins, minerals, and fatty acids. This study was carried out to elucidate the anticancer…
View article: Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by Aloe vera in Wistar Rats
Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by Aloe vera in Wistar Rats Open
Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian…
View article: Combined Supplementation of Clostridium butyricum and Bifidobacterium infantis Diminishes Chronic Unpredictable Mild Stress-Induced Intestinal Alterations via Activation of Nrf-2 Signaling Pathway in Rats
Combined Supplementation of Clostridium butyricum and Bifidobacterium infantis Diminishes Chronic Unpredictable Mild Stress-Induced Intestinal Alterations via Activation of Nrf-2 Signaling Pathway in Rats Open
Exposure to long-term chronic unpredictable mild stress (CUMS) can cause redox imbalance and inflammation, which may affect the integrity of the gut barrier. The present study was conducted to investigate the effects of a probiotics bacter…
View article: Hybrid Nanoparticles of Manganese Oxide and Highly Reduced Graphene Oxide for Photodynamic Therapy
Hybrid Nanoparticles of Manganese Oxide and Highly Reduced Graphene Oxide for Photodynamic Therapy Open
Background: Graphene-based nanomaterials possess unique optical, physicochemical and biomedical properties which make them potential tools for imaging and therapy. Manganese oxide nanoparticles are attractive candidates for contrast agents…
View article: Phytochemical Profiling of Microalgae Euglena tuba and Its Anticancer Activity in Dalton's Lymphoma Cells
Phytochemical Profiling of Microalgae Euglena tuba and Its Anticancer Activity in Dalton's Lymphoma Cells Open
Introduction: Natural phytochemicals are considered safe to use as therapeutic agents. There is a growing trend toward exploring anticancer effects of crude algal extracts or their active ingredients. Euglena tuba, a microalga, contains ex…
View article: In-Utero Neurotoxicity of Nanoparticles
In-Utero Neurotoxicity of Nanoparticles Open
The unique physicochemical properties of nanoparticles (NPs) make them widely used in cosmetics, medicines, food additives, and antibacterial and antiviral compounds. NPs are also used in therapy and diagnostic applications. Depending on t…
View article: Effect of Dietary Natural Growth Promoters on the Liver Function Enzymes of Chicken Challenged with Clostridium perfringens
Effect of Dietary Natural Growth Promoters on the Liver Function Enzymes of Chicken Challenged with Clostridium perfringens Open
In this study four groups of chicken challenged with Clostridium perfringens were fed on Neoxyval, GalliPro, TechnoMos and GalliPro + TechnoMos.A group fed on normal diet was used as control and the other challenged with bacterium was main…
View article: Comparative evaluation of cadmium-induced oxidative stress in camel and bovine erythrocytes
Comparative evaluation of cadmium-induced oxidative stress in camel and bovine erythrocytes Open
Objectives: Erythrocytes or red blood cells (RBCs) are the most abundant cells in blood. They transport oxygen from lungs to tissues and bring back carbon dioxide from tissues to lungs. Being non-nucleated and lacking the cellular organell…
View article: Protective effect of eugenol on hepatic inflammation and oxidative stress induced by cadmium in male rats
Protective effect of eugenol on hepatic inflammation and oxidative stress induced by cadmium in male rats Open
View article: Anti-Inflammatory and Antioxidative Potential of Aloe vera on the Cartap and Malathion Mediated Toxicity in Wistar Rats
Anti-Inflammatory and Antioxidative Potential of Aloe vera on the Cartap and Malathion Mediated Toxicity in Wistar Rats Open
Aloe vera has been the most useful medicinal herb in the world since ancient times due to its vast biological effects. The presence of high content of bioactive compounds make Aloe vera a promising complementary and alternative agent in di…
View article: Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Induce Aging by Inhibiting Telomerase Function
Nucleoside and Nucleotide Reverse Transcriptase Inhibitors Induce Aging by Inhibiting Telomerase Function Open
The telomeres existing at the end of the eukaryotic chromosome, play an important role in localization, pairing of homologous chromosomes during cell division and synapsis formation, while telomerase is involved in maintenance of the telom…
View article: Reproductive Toxicity of Pomegranate Peel Extract Synthesized Gold Nanoparticles: A Multigeneration Study in <i>C. elegans</i>
Reproductive Toxicity of Pomegranate Peel Extract Synthesized Gold Nanoparticles: A Multigeneration Study in <i>C. elegans</i> Open
C. elegans is a preferential model for testing environmental toxicity of compounds including nanomaterials. The impact of multigeneration exposure of gold nanoparticles (AuNPs) on the lifespan and fertility of C. elegans is not known and t…
View article: Time-Course Evaluation of Iminodipropionitrile-Induced Liver and Kidney Toxicities in Rats: A Biochemical, Molecular and Histopathological Study
Time-Course Evaluation of Iminodipropionitrile-Induced Liver and Kidney Toxicities in Rats: A Biochemical, Molecular and Histopathological Study Open
Iminodipropionitrile (IDPN) is known to produce axonopathy and vestibular hair cell degeneration. Recent histopathological studies have shown IDPN-induced liver and kidney toxicities in rodents; however, the associated mechanisms are not c…
View article: An insight into the anticancer mechanism of Tribulus terrestris extracts on human breast cancer cells
An insight into the anticancer mechanism of Tribulus terrestris extracts on human breast cancer cells Open
View article: Effect of acrylamide and alpha lipoic acid treatment on oxidative stress and antioxidant defence indices in rat brain
Effect of acrylamide and alpha lipoic acid treatment on oxidative stress and antioxidant defence indices in rat brain Open
This dataset consists of a single data table in .docx MS Word format presenting various oxidative stress and antioxidant defence indices in different rat groups undergoing acrylamide and alpha lipoic acid treatment.Variables measured pe…
View article: Synergistic Effect of Quercetin and<i>α</i>-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats
Synergistic Effect of Quercetin and<i>α</i>-Lipoic Acid on Aluminium Chloride Induced Neurotoxicity in Rats Open
Objectives . The present study was carried out to study the protective effects of quercetin and α -lipoic acid alone and in combination against aluminum chloride induced neurotoxicity in rats. Materials and Methods . The study consisted of…
View article: Aging, Metabolic, and Degenerative Disorders: Biomedical Value of Antioxidants
Aging, Metabolic, and Degenerative Disorders: Biomedical Value of Antioxidants Open
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View article: Curcumin mediated attenuation of carbofuran induced toxicity in the heart of Wistar rats
Curcumin mediated attenuation of carbofuran induced toxicity in the heart of Wistar rats Open
Carbofuran is used to improve the agricultural productivity as well as to protect the house hold and industrial products, but due to accumulation in the biological system, it causes serious side effects in many non-targets mammalian system…
View article: Effects of alpha lipoic acid on acrylamide-induced hepatotoxicity in rats
Effects of alpha lipoic acid on acrylamide-induced hepatotoxicity in rats Open
Acrylamide (ACR) is a neurotoxicant, reproductive toxicant, and carcinogen in animal species. It is used in many industries and has been found to form naturally in foods cooked at high temperatures. Alpha-lipoic acid (ALA) is a naturally o…