Nikhil Bhalla
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View article: Nanoplasmonics Reveal Ionic‐Strength‐Driven Hydration of Nanoparticles
Nanoplasmonics Reveal Ionic‐Strength‐Driven Hydration of Nanoparticles Open
Localized surface plasmon resonance (LSPR) in gold nanoparticles (AuNPs) provides an ultrasensitive probe of interfacial hydration dynamics, yet the quantitative role of ionic‐strength‐modulated hydration shells in governing both non‐radia…
View article: Resolving Nanoslip, Solvation Inertia, and Charge Dynamics at Vibrating Solid–Liquid Interface
Resolving Nanoslip, Solvation Inertia, and Charge Dynamics at Vibrating Solid–Liquid Interface Open
When a liquid contacts a charged solid surface, counterions in the liquid accumulate near the interface—a process traditionally described by models such as Helmholtz, Stern, and Debye‐Hückel. However, these frameworks overlook the complex …
View article: Plasmonic Geometry-Induced Viscoelastic Biocomplex Formation with Optical Concealment, Liquid Slips, and Soundscapes in Bioassays
Plasmonic Geometry-Induced Viscoelastic Biocomplex Formation with Optical Concealment, Liquid Slips, and Soundscapes in Bioassays Open
Plasmonic nanoparticles (NPs), typically made up of gold or silver, are widely used in point-of-care bio- and chemical sensing due to their role in enhancing detection sensitivity. Key NP properties influencing sensing performance include …
View article: Sensing Pico‐Newton Plasmonic Forces and Jerks of LSPR Biochips Using Simple UV‐Visible Spectroscopy
Sensing Pico‐Newton Plasmonic Forces and Jerks of LSPR Biochips Using Simple UV‐Visible Spectroscopy Open
Localized surface plasmon resonances (LSPRs) involve the oscillation of free electrons, leading to the maximum absorption of light by nanostructures at a specific wavelength. This absorption generates an action force exerted by the light o…
View article: Interdisciplinary Approach to Monkeypox Prevention: Integrating Nanobiosensors, Nanovaccines, Artificial Intelligence, Visual Arts, and Social Sciences
Interdisciplinary Approach to Monkeypox Prevention: Integrating Nanobiosensors, Nanovaccines, Artificial Intelligence, Visual Arts, and Social Sciences Open
To effectively address crisis emergence of new virus such as monkeypox, a collective and collaborative effort between scientists, engineers, innovators, and artists from all ages, regions, and diverse fields is required. This review explor…
View article: Review—Cancer Biosensing Using Plasmonic Metal Doped Graphene-Based Materials
Review—Cancer Biosensing Using Plasmonic Metal Doped Graphene-Based Materials Open
This review investigates plasmonic metal doped graphene-based materials used in biosensors for cancer detection. Plasmonic metals and graphene-based materials are known for their electrical conductivity, high surface area, and biocompatibi…
View article: Nanoparticles alter locust development and behaviour
Nanoparticles alter locust development and behaviour Open
The image illustrates the effect of nanoparticle-treated lettuce on locusts, showing their initial avoidance, eventual feeding, and subsequent death, suggesting a potential pest control strategy.
View article: Exploring the Potential of Phosphorene and Arsenene in Plasmonic and 2D Nanomaterial-based Biosensing: From Fundamentals to Applications
Exploring the Potential of Phosphorene and Arsenene in Plasmonic and 2D Nanomaterial-based Biosensing: From Fundamentals to Applications Open
Two-dimensional nanomaterials such as phosphorene and arsenene have emerged as transformative platforms for next-generation biosensing, owing to their exceptional electronic, optical, and mechanical properties. Phosphorene, derived from bl…
View article: Incongruous Harmonics of Vibrating Solid‐Solid Interface
Incongruous Harmonics of Vibrating Solid‐Solid Interface Open
Deconvoluting the vibrations and harmonics in solid‐solid interfaces is crucial for designing materials with improved performance, durability, and functionality. The measured vibrating microcantilever signal in the dynamic atomic force mic…
View article: Acoustic Fingerprinting and Nanoslip Dynamics of Biofilms
Acoustic Fingerprinting and Nanoslip Dynamics of Biofilms Open
It is reported that bacteria can generate nanomotion, but understanding the complex dynamics of bacterial colony gliding on solid interfaces has remained unresolved. Here, this work captures the real‐time development and gliding of bacteri…
View article: Nose-on-Chip Nanobiosensors for Early Detection of Lung Cancer Breath Biomarkers
Nose-on-Chip Nanobiosensors for Early Detection of Lung Cancer Breath Biomarkers Open
Lung cancer remains a global health concern, demanding the development of noninvasive, prompt, selective, and point-of-care diagnostic tools. Correspondingly, breath analysis using nanobiosensors has emerged as a promising noninvasive nose…
View article: Decoupling Variable Capacitance and Diffusive Components of Active Solid–Liquid Interfaces with Flex Points
Decoupling Variable Capacitance and Diffusive Components of Active Solid–Liquid Interfaces with Flex Points Open
Understanding the current transport characteristics of electrode interfaces is essential for optimizing device performance across a wide range of applications including bio-/chemical sensing and energy storage sectors. Cyclic voltammetry (…
View article: Combating Prozone Effects and Predicting the Dynamic Range of Naked-Eye Nanoplasmonic Biosensors through Capture Bioentity Optimization
Combating Prozone Effects and Predicting the Dynamic Range of Naked-Eye Nanoplasmonic Biosensors through Capture Bioentity Optimization Open
Accurately quantifying high analyte concentrations poses a challenge due to the common occurrence of the prozone or hook effect within sandwich assays utilized in plasmonic nanoparticle-based lateral flow devices (LFDs). As a result, LFDs …
View article: Localized Surface Plasmon Resonance Sensing and its Interplay with Fluidics
Localized Surface Plasmon Resonance Sensing and its Interplay with Fluidics Open
In this Feature Article, we discuss the interplay between fluidics and the localized surface plasmon resonance (LSPR) sensing technique, primarily focusing on its applications in the realm of bio/chemical sensing within fluidic environment…
View article: High selectivity and sensitivity through nanoparticle sensors for cleanroom CO<sub>2</sub> detection
High selectivity and sensitivity through nanoparticle sensors for cleanroom CO<sub>2</sub> detection Open
Clean room facilities are becoming more popular in both academic and industry settings, including low-and middle-income countries. This has led to an increased demand for cost-effective gas sensors to monitor air quality. Here we have deve…
View article: Pangenome-wide association study reveals selective absence of CRISPR genes (Rv2816c-19c) in drug-resistant<i>Mycobacterium tuberculosis</i>
Pangenome-wide association study reveals selective absence of CRISPR genes (Rv2816c-19c) in drug-resistant<i>Mycobacterium tuberculosis</i> Open
Background The drug resistance development in Mycobacterium tuberculosis (Mtb) is attributed to the acquisition of mutations in the drug target genes. However, the role of the differential presence of non-essential accessory genes is relat…
View article: Unconventional Breathing Currents Far beyond the Quantum Tunneling Distances in Large-Gapped Nanoplasmonic Systems
Unconventional Breathing Currents Far beyond the Quantum Tunneling Distances in Large-Gapped Nanoplasmonic Systems Open
Localized surface plasmon resonance (LSPR) in plasmonic nanoparticles propels the field of plasmo-electronics, holding promise for transformative optoelectronic devices through efficient light-to-current conversion. Plasmonic excitations s…
View article: Measurement of Human Urine Specific Gravity Using Nanoplasmonics: A Paradigm Shift from Scales to Biosensors
Measurement of Human Urine Specific Gravity Using Nanoplasmonics: A Paradigm Shift from Scales to Biosensors Open
Urine Specific Gravity (U SG ) is a direct indicator of the osmolarity of the urine and therefore it can be considered as a nonspecific marker of several underlying diseases which result in changes in hydration levels of the body. Here, a …
View article: Refractive Index-Modulated LSPR Sensing in 20–120 nm Gold and Silver Nanoparticles: A Simulation Study
Refractive Index-Modulated LSPR Sensing in 20–120 nm Gold and Silver Nanoparticles: A Simulation Study Open
Localized surface plasmon resonance (LSPR) based sensing has been a simple and cost-effective way to measure local refractive index changes. LSPR materials exhibit fascinating properties that have significant implications for various bio/c…
View article: Recognizing the Less Explored “Active Solid”–“Moving Liquid” Interfaces in Bio/Chemical Sensors
Recognizing the Less Explored “Active Solid”–“Moving Liquid” Interfaces in Bio/Chemical Sensors Open
Bio/chemical sensors possess a plethora of advantageous features that have proven to be invaluable tools in detecting and monitoring biomolecules, facilitating advancements in healthcare, environmental monitoring, food safety, and more. Ho…
View article: Sensor-Free Biosensing of Mitral and Aortic Valvular Function During Continuous Flow Left Ventricular Assist Device Support
Sensor-Free Biosensing of Mitral and Aortic Valvular Function During Continuous Flow Left Ventricular Assist Device Support Open
Objective : Continuous Flow Left Ventricular Assist Devices (CF-LVADs) are miniaturised devices supporting the failing left ventricle and alter the blood flow in the cardiovascular system which may cause severe health complications. Regurg…
View article: Single‐Step Primary Amine Synthesis on Proton Sensitive Nanofilms to Overcome Its Debye Length Limitations
Single‐Step Primary Amine Synthesis on Proton Sensitive Nanofilms to Overcome Its Debye Length Limitations Open
The debye length is a measure of the distance over which the electric field of a charged particle decays in an electrolyte solution. If the binding of the analyte to the surface of the transducer is too far away from the surface, the elect…
View article: Sensing Dynamically Evolved Short‐Range Nanomechanical Forces in Fast‐Mutating Single Viral Spike Proteins
Sensing Dynamically Evolved Short‐Range Nanomechanical Forces in Fast‐Mutating Single Viral Spike Proteins Open
Understanding changes in the mechanical features of a single protein from a mutated virus while establishing its relation to the point mutations is critical in developing new inhibitory routes to tackle the uncontrollable spread of the vir…
View article: Point-of-care diagnostics for sepsis using clinical biomarkers and microfluidic technology
Point-of-care diagnostics for sepsis using clinical biomarkers and microfluidic technology Open
View article: Effect of Selenium Nanoparticle Size on IL-6 Detection Sensitivity in a Lateral Flow Device
Effect of Selenium Nanoparticle Size on IL-6 Detection Sensitivity in a Lateral Flow Device Open
Sepsis is the body's response to an infection. Existing diagnostic testing equipment is not available in primary care settings and requires long waiting times. Lateral flow devices (LFDs) could be employed in point-of-care (POC) settings f…
View article: Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing (Adv. Mater. Interfaces 1/2023)
Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing (Adv. Mater. Interfaces 1/2023) Open
Optical Nano-Biosensors An optical nanobiosensor is reported in article number 2201261 by Jacob Waitkus and co-workers. Localized surface plasmon resonance (LSPR) allows for sensitive detection of alterations to the local refractive index …
View article: Addressing the Silent Spread of Monkeypox Disease with Advanced Analytical Tools
Addressing the Silent Spread of Monkeypox Disease with Advanced Analytical Tools Open
Monkeypox disease is caused by a virus which belongs to the orthopoxvirus genus of the poxviridae family. This disease has recently spread out to several non‐endemic countries. While some cases have been linked to travel from endemic regio…
View article: Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing
Gold Nanoparticle Enabled Localized Surface Plasmon Resonance on Unique Gold Nanomushroom Structures for On‐Chip CRISPR‐Cas13a Sensing Open
A novel localized surface plasmon resonance (LSPR) system based on the coupling of gold nanomushrooms (AuNMs) and gold nanoparticles (AuNPs) is developed to enable a significant plasmonic resonant shift. The AuNP size, surface chemistry, a…
View article: Unraveling the liquid gliding on vibrating solid liquid interfaces with dynamic nanoslip enactment
Unraveling the liquid gliding on vibrating solid liquid interfaces with dynamic nanoslip enactment Open
View article: Measuring the Radius of Gyration and Intrinsic Flexibility of Viral Proteins in Buffer Solution Using Small-Angle X-ray Scattering
Measuring the Radius of Gyration and Intrinsic Flexibility of Viral Proteins in Buffer Solution Using Small-Angle X-ray Scattering Open
Measuring structural features of proteins dispersed in buffer solution, in contrast to crystal form, is indispensable in understanding morphological characteristics of the biomolecule in a native environment. We report on the structure and…