Nikhil Bharambe
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View article: Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM
Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM Open
Pentameric ligand-gated ion channels (pLGICs) are vital neurotransmitter receptors that are key therapeutic targets for neurological disorders. Although the high-resolution structures of these channels have been elucidated, capturing their…
View article: GLIC in MSP1E3D1 nanodisc at pH 7.5 (asolectin)
GLIC in MSP1E3D1 nanodisc at pH 7.5 (asolectin) Open
View article: GLIC in MSP1E3D1 nanodisc at pH 5.5
GLIC in MSP1E3D1 nanodisc at pH 5.5 Open
View article: Cryo-EM structure of the 55 kDa nucleoplasmin domain of AtFKBP53
Cryo-EM structure of the 55 kDa nucleoplasmin domain of AtFKBP53 Open
View article: Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment
Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment Open
View article: Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C
Identification of Phosphorylation and Other Post-Translational Modifications in the Central C4C5 Domains of Murine Cardiac Myosin Binding Protein C Open
Cardiac myosin binding protein C (cMyBPC) is a critical multidomain protein that modulates myosin cross bridge behavior and cardiac contractility. cMyBPC is principally regulated by phosphorylation of the residues within the M-domain of it…
View article: Molecular characterization of linker and loop-mediated structural modulation and hinge motion in the C4-C5 domains of cMyBPC
Molecular characterization of linker and loop-mediated structural modulation and hinge motion in the C4-C5 domains of cMyBPC Open
View article: NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission
NMR identification of a conserved Drp1 cardiolipin-binding motif essential for stress-induced mitochondrial fission Open
Significance The large cytosolic GTPase dynamin-related protein 1 (Drp1) self-assembles around mitochondria to mechanoenzymatically constrict and divide the double-membrane–bound organelle. Although Drp1 recruitment to the mitochondrial su…
View article: AAV9 gene transfer of cMyBPC N-terminal domains ameliorates cardiomyopathy in cMyBPC-deficient mice
AAV9 gene transfer of cMyBPC N-terminal domains ameliorates cardiomyopathy in cMyBPC-deficient mice Open
Decreased cardiac myosin-binding protein C (cMyBPC) expression due to inheritable mutations is thought to contribute to the hypertrophic cardiomyopathy (HCM) phenotype, suggesting that increasing cMyBPC content is of therapeutic benefit. I…
View article: Crystal Structure of MiD51 Bound to Phospholipid
Crystal Structure of MiD51 Bound to Phospholipid Open
View article: ADP-Regulated MiD51-Phospholipid Interactions Couple Cellular Bioenergetics to Mitochondrial Membrane Remodeling
ADP-Regulated MiD51-Phospholipid Interactions Couple Cellular Bioenergetics to Mitochondrial Membrane Remodeling Open
View article: Structural and Mechanistic Bases of Drp1-Cardiolipin Interactions in Mitochondrial Fission
Structural and Mechanistic Bases of Drp1-Cardiolipin Interactions in Mitochondrial Fission Open
View article: Substrate specificity determinants of class <scp>III</scp> nucleotidyl cyclases
Substrate specificity determinants of class <span>III</span> nucleotidyl cyclases Open
The two second messengers in signalling, cyclic AMP and cyclic GMP , are produced by adenylyl and guanylyl cyclases respectively. Recognition and discrimination of the substrates ATP and GTP by the nucleotidyl cyclases are vital in these r…