Nikhil Gupte
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View article: Improving Treatment Adherence in Youths With Multidrug‐Resistant Tuberculosis With Psychosocial Intervention
Improving Treatment Adherence in Youths With Multidrug‐Resistant Tuberculosis With Psychosocial Intervention Open
Introduction Multidrug‐resistant tuberculosis (MDR‐TB) deeply impacts the well‐being of adolescents and young adults (AYA), resulting in poor treatment adherence. Identifying psychosocial challenges and preferred interventions is essential…
View article: The Nicotine Metabolite Ratio and Response to Smoking Cessation Treatment Among People Living with HIV Who Smoke in South Africa
The Nicotine Metabolite Ratio and Response to Smoking Cessation Treatment Among People Living with HIV Who Smoke in South Africa Open
The nicotine metabolite ratio (NMR) has been informative in selecting treatment choices for nicotine dependence and increasing treatment efficacy in Western settings; however, the clinical utility of the NMR among smokers in low-resource s…
View article: Pseudomelanosis Gastri: The Dark Side of Antihypertensives
Pseudomelanosis Gastri: The Dark Side of Antihypertensives Open
View article: Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India
Discordance of 3rd and 4th generation QuantiFERON-TB Gold assays by pregnancy stages in India Open
View article: Clinical and laboratory risk factors for pulmonary tuberculosis recurrence in three pooled Indian cohorts
Clinical and laboratory risk factors for pulmonary tuberculosis recurrence in three pooled Indian cohorts Open
Some individuals with drug-susceptible pulmonary tuberculosis (PTB) experience tuberculosis recurrence. To evaluate the incidence of and risk factors for recurrence following completion of antituberculosis therapy, we pooled data from thre…
View article: Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India
Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India Open
In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-mont…
View article: Drug Resistance and Epidemiological Success of Modern <i>Mycobacterium tuberculosis</i> Lineages in Western India
Drug Resistance and Epidemiological Success of Modern <i>Mycobacterium tuberculosis</i> Lineages in Western India Open
Background Drivers of tuberculosis (TB) transmission in India, the country estimated to carry a quarter of the world's burden, are not well studied. We conducted a genomic epidemiology study to compare epidemiological success, host factors…
View article: Correction: Tuberculosis (TB) Aftermath: study protocol for a hybrid type I effectiveness-implementation non-inferiority randomized trial in India comparing two active case finding (ACF) strategies among individuals treated for TB and their household contacts
Correction: Tuberculosis (TB) Aftermath: study protocol for a hybrid type I effectiveness-implementation non-inferiority randomized trial in India comparing two active case finding (ACF) strategies among individuals treated for TB and their household contacts Open
View article: Discordance of 3rd and 4th Generation Quantiferon-Tb Gold Assays by Pregnancy Stages in India
Discordance of 3rd and 4th Generation Quantiferon-Tb Gold Assays by Pregnancy Stages in India Open
View article: Early Microbiologic Markers of Pulmonary Tuberculosis Treatment Outcomes
Early Microbiologic Markers of Pulmonary Tuberculosis Treatment Outcomes Open
Rationale: Earlier biomarkers of pulmonary tuberculosis (PTB) treatment outcomes are critical to monitor shortened anti-TB treatment (ATT). Objectives: To identify early microbiologic markers of unfavorable TB treatment outco…
View article: 1953. Impact of Baseline Nutritional Status on Tuberculosis Severity in India: a multicenter prospective cohort analysis
1953. Impact of Baseline Nutritional Status on Tuberculosis Severity in India: a multicenter prospective cohort analysis Open
Background India bears a quarter of the global tuberculosis (TB) burden. Previous studies have shown that more than 50% of persons with TB in India are undernourished and that undernutrition is associated with increased risk of unfavorable…
View article: Glycated Hemoglobin Trajectories and Their Association With Treatment Outcomes Among Patients With Pulmonary TB in India
Glycated Hemoglobin Trajectories and Their Association With Treatment Outcomes Among Patients With Pulmonary TB in India Open
View article: Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection
Comparative immune responses to Mycobacterium tuberculosis in people with latent infection or sterilizing protection Open
View article: A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction
A multi-center, prospective cohort study of whole blood gene expression in the tuberculosis-diabetes interaction Open
View article: A Cross-Sectional Analysis of the Nicotine Metabolite Ratio and Its Association with Sociodemographic and Smoking Characteristics among People with HIV Who Smoke in South Africa
A Cross-Sectional Analysis of the Nicotine Metabolite Ratio and Its Association with Sociodemographic and Smoking Characteristics among People with HIV Who Smoke in South Africa Open
The nicotine metabolite ratio (NMR) is associated with race/ethnicity but has not been evaluated among smokers in the African region. We conducted a cross-sectional analysis of baseline data from a large randomized, controlled trial for sm…
View article: Virological failure among people living with HIV receiving second-line antiretroviral therapy in Pune, India
Virological failure among people living with HIV receiving second-line antiretroviral therapy in Pune, India Open
View article: Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis
Impact of Undernutrition on Tuberculosis Treatment Outcomes in India: A Multicenter, Prospective, Cohort Analysis Open
Background Undernutrition is the leading risk factor for tuberculosis (TB) globally. Its impact on treatment outcomes is poorly defined. Methods We conducted a prospective cohort analysis of adults with drug-sensitive pulmonary TB at 5 sit…
View article: Sex Differences in TB Clinical Presentation, Drug Exposure, and Treatment Outcomes in India
Sex Differences in TB Clinical Presentation, Drug Exposure, and Treatment Outcomes in India Open
View article: Tuberculosis (TB) Aftermath: study protocol for a hybrid type I effectiveness-implementation non-inferiority randomized trial in India comparing two active case finding (ACF) strategies among individuals treated for TB and their household contacts
Tuberculosis (TB) Aftermath: study protocol for a hybrid type I effectiveness-implementation non-inferiority randomized trial in India comparing two active case finding (ACF) strategies among individuals treated for TB and their household contacts Open
Background Approximately 7% of all reported tuberculosis (TB) cases each year are recurrent, occurring among people who have had TB in the recent or distant past. TB recurrence is particularly common in India, which has the largest TB burd…
View article: The Association of Gestational Diabetes with HIV Infection and Tuberculosis in Indian Women
The Association of Gestational Diabetes with HIV Infection and Tuberculosis in Indian Women Open
Infection of HIV is associated with an increased diabetes risk, which also increases tuberculosis risk. It is unknown if similar associations exist with gestational diabetes (GDM). We screened pregnant women living with and without HIV for…
View article: Virological failure and treatment switch after ART initiation among people living with HIV with and without routine viral load monitoring in Asia
Virological failure and treatment switch after ART initiation among people living with HIV with and without routine viral load monitoring in Asia Open
Introduction Viral load (VL) testing is still challenging to monitor treatment responses of antiretroviral therapy (ART) for HIV treatment programme in Asia. We assessed the association between routine VL testing and virological failure (V…
View article: Smokeless tobacco use and oral potentially malignant disorders among people living with HIV (PLHIV) in Pune, India: Implications for oral cancer screening in PLHIV
Smokeless tobacco use and oral potentially malignant disorders among people living with HIV (PLHIV) in Pune, India: Implications for oral cancer screening in PLHIV Open
Introduction In India, smokeless tobacco (SLT) is a predominant form of tobacco used among people living with HIV (PLHIV). Despite SLT being a risk factor for oral potentially malignant disorders (OPMDs), no prior studies have quantified t…
View article: Association of national and regional lockdowns with COVID-19 infection rates in Pune, India
Association of national and regional lockdowns with COVID-19 infection rates in Pune, India Open
View article: Comparative immune responses to<i>Mycobacterium tuberculosis</i>in people with latent infection or sterilizing protection
Comparative immune responses to<i>Mycobacterium tuberculosis</i>in people with latent infection or sterilizing protection Open
Tuberculosis (TB) affects 2 billion people worldwide and causes 1.5 million deaths every year. There is great need for new TB vaccines that are more efficacious than the currently licensed BCG vaccine, which provides only limited protectio…
View article: Concomitant pulmonary disease is common among patients with extrapulmonary TB
Concomitant pulmonary disease is common among patients with extrapulmonary TB Open
BACKGROUND: Microbiologic screening of extrapulmonary TB (EPTB) patients could inform recommendations for aerosol precautions and close contact prophylaxis. However, this is currently not routinely recommended in India. Therefore, we estim…
View article: Performance of Xpert<sup>®</sup> MTB/RIF and Xpert<sup>®</sup> Ultra for the diagnosis of tuberculous meningitis in children
Performance of Xpert<sup>®</sup> MTB/RIF and Xpert<sup>®</sup> Ultra for the diagnosis of tuberculous meningitis in children Open
OBJECTIVE: To assess Xpert ® MTB/RIF (Xpert) and Xpert ® MTB/RIF Ultra (Ultra) performance in diagnosing pediatric tuberculous meningitis (TBM). METHODS: We conducted a study among children with suspected meningoencephalitis in Pune, India…
View article: Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial
Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial Open
Background Pediatric tuberculous meningitis (TBM) commonly causes death or disability. In adults, high-dose rifampicin may reduce mortality. The role of fluoroquinolones remains unclear. There have been no antimicrobial treatment trials fo…
View article: Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial
Early Bactericidal Activity of Meropenem plus Clavulanate (with or without Rifampin) for Tuberculosis: The COMRADE Randomized, Phase 2A Clinical Trial Open
Rationale: Carbapenems are recommended for treatment of drug-resistant tuberculosis. Optimal dosing remains uncertain. Objectives: To evaluate the 14-day bactericidal activity of meropenem, at different doses, with or without…
View article: The Kynurenine/Tryptophan Ratio Is a Sensitive Biomarker for the Diagnosis of Pediatric Tuberculosis Among Indian Children
The Kynurenine/Tryptophan Ratio Is a Sensitive Biomarker for the Diagnosis of Pediatric Tuberculosis Among Indian Children Open
Objectives Pediatric tuberculosis (TB) remains difficult to diagnose. The plasma kynurenine to tryptophan ratio (K/T ratio) is a potential biomarker for TB diagnosis and treatment response but has not been assessed in children. Methods We …
View article: Modern lineages of <i>Mycobacterium tuberculosis</i> were recently introduced in western India and demonstrate increased transmissibility
Modern lineages of <i>Mycobacterium tuberculosis</i> were recently introduced in western India and demonstrate increased transmissibility Open
Background Mycobacterium tuberculosis ( Mtb ) transmissibility may vary between lineages (or variants) and this may contribute to the slow decline of tuberculosis (TB) incidence. The objective of our study was to compare transmissibility a…