Nikhil Panicker
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View article: Sterile Innate Immune Mechanisms in Neurodegenerative diseases
Sterile Innate Immune Mechanisms in Neurodegenerative diseases Open
View article: Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer’s Disease Model
Poly(ADP-ribose) Polymerase 1 Deficiency Attenuates Amyloid Pathology, Neurodegeneration, and Cognitive Decline in a Familial Alzheimer’s Disease Model Open
Poly(ADP-ribose) (PAR) polymerase-1 (PARP1) has been implicated in DNA damage responses and neuroinflammation in Alzheimer’s disease (AD), yet its role in amyloid-β (Aβ) pathology remains unclear. Here, we show that PARP1 activation drives…
View article: A knowledge update on current strategies on the prevention and control of rabies in Ethiopia
A knowledge update on current strategies on the prevention and control of rabies in Ethiopia Open
View article: Postclosure Criticality Analysis Results
Postclosure Criticality Analysis Results Open
The United States Department of Energy’s (DOE) Office of Nuclear Energy’s Spent Fuel and Waste Science and Technology Campaign seeks to better understand the technical basis, risks, and uncertainty associated with the safe and secure dispo…
View article: Inflammasome assembly in neurodegenerative diseases
Inflammasome assembly in neurodegenerative diseases Open
View article: Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease Open
View article: STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy
STING mediates neurodegeneration and neuroinflammation in nigrostriatal α-synucleinopathy Open
Significance It is increasingly recognized that chronic neuroinflammation is causally relevant to neurodegeneration. In Parkinson’s disease (PD), α-synuclein pathology activates inflammatory signaling that disturbs parenchymal homeostasis …
View article: Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson’s disease
Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson’s disease Open
Mutations in PINK1 and parkin highlight the mitochondrial axis of Parkinson’s disease (PD) pathogenesis. PINK1/parkin regulation of the transcriptional repressor PARIS bears direct relevance to dopamine neuron survival through augmentation…
View article: The cell biology of Parkinson’s disease
The cell biology of Parkinson’s disease Open
Parkinson’s disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our understanding of PD biology has been enriched by the identification of genes invol…
View article: Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease
Kv1.3 modulates neuroinflammation and neurodegeneration in Parkinson’s disease Open
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of these targets can provide potential treatments to hal…
View article: Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research
Fyn kinase mediates pro-inflammatory response in a mouse model of endotoxemia: Relevance to translational research Open
View article: Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease
Fyn amplifies NLRP3 inflammasome signaling in Parkinson's disease Open
View article: Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease Open
View article: Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein
Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of α-synuclein Open
Manganese exposure promotes α-synuclein propagation, neuroinflammation, and neurodegeneration.
View article: Faculty Opinions recommendation of TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging.
Faculty Opinions recommendation of TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. Open
Aging is a major risk factor for both genetic and sporadic neurodegenerative disorders.However, it is unclear how aging interacts with genetic predispositions to promote neurodegeneration.Here we investigate how partial loss-of-function of…
View article: Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease Open
View article: Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease
Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson’s disease Open
The NLRP3 inflammasome signaling pathway is a major contributor to the neuroinflammatory process in the central nervous system. Oxidative stress and mitochondrial dysfunction are key pathophysiological processes of many chronic neurodegene…
View article: Neurotoxic reactive astrocytes are induced by activated microglia
Neurotoxic reactive astrocytes are induced by activated microglia Open
View article: Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration
Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration Open
View article: Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3
Pathological α-synuclein transmission initiated by binding lymphocyte-activation gene 3 Open
INTRODUCTION Parkinson’s disease (PD) is the second most common neurodegenerative disorder and leads to slowness of movement, tremor, rigidity, and, in the later stages of PD, cognitive impairment. Pathologically, PD is characterized by th…
View article: Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease
Protein kinase Cδ upregulation in microglia drives neuroinflammatory responses and dopaminergic neurodegeneration in experimental models of Parkinson's disease Open
View article: The role of Fyn kinase in mediating microglial pro-inflammatory responses in Parkinson's disease
The role of Fyn kinase in mediating microglial pro-inflammatory responses in Parkinson's disease Open
View article: Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease
Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson's Disease Open
Parkinson's disease (PD) is a complex multifactorial disease characterized by the progressive loss of midbrain dopamine neurons. Sustained microglia-mediated neuroinflammation has been recognized as a major pathophysiological contributor t…