Explanipedia

Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence Open

Daniel Rodrigo‐Torres, Alastair M. Kilpatrick, Sofía Ferreira-González, Rhona Aird, Stephen R. Atkinson , et al. · 2025

Background and aims Alcohol-associated hepatitis (AH) is an acute form of alcohol-related liver disease (ALD) with high mortality rate. AH is histologically characterised by cellular processes, including steatosis, inflammation and cell de…

Lipidomics-based plasma signature of alcohol-related hepatitis linked to short-term mortality Open

Florent Artru, Stephen D. Atkinson, Francesca M. Trovato, Luke D. Tyson, Vishal Patel , et al. · 2025

Mitochondrial dysfunction underlies monocyte immune deficiency in patients with severe alcohol-related hepatitis Open

Paul Middleton, Ricardo Aramayo, Alex Montoya, Pavel V. Shliaha, Simon Pope , et al. · 2025

Severe alcohol-related hepatitis (sAH) is a life-threatening form of alcohol-related liver disease (ARLD) associated with a significant short-term mortality. Opportunistic infections due to impaired immune function are a major cause of pat…

IL-1 Signal Inhibition in Alcohol-Related Hepatitis: A Randomized, Double-Blind, Placebo-Controlled Trial of Canakinumab Open

Nikhil Vergis, Vishal C. Patel, Karolina Bogdanowicz, Justyna Czyzewska-Khan, Rosemary Keshinro , et al. · 2024

CAN therapy in severe AH participants with Model for End-Stage Liver Disease ≤27 did not alter biochemical or clinical outcomes compared with PBO. Nonsignificant histological improvements did not translate into clinical benefit. EudraCT, N…

Healthcare interactions prior to first hospital admission with alcohol‐related liver disease Open

Heather Lewis, Richard Parker, Zia Ul Haq, Amanda Lucas, Carole Cohen , et al. · 2024

Background and Aims To examine the healthcare contacts of patients in the year before an index admission to hospital with alcohol‐related liver disease (ArLD) to identify where opportunities for earlier identification of alcohol use disord…

Editorial: Unmasking the silent threat—acute kidney injury in alcohol‐associated hepatitis. Authors' reply Open

Luke D. Tyson, Stephen R. Atkinson, Robert W. Hunter, Mark Thursz, Nikhil Vergis · 2023

LINKED CONTENT This article is linked to Tyson et al papers. To view these articles, visit https://doi.org/10.1111/apt.17733 and https://doi.org/10.1111/apt.17771

In severe alcohol‐related hepatitis, acute kidney injury is prevalent, associated with mortality independent of liver disease severity, and can be predicted using <span>IL</span>‐8 and <span>micro‐RNAs</span> Open

Luke D. Tyson, Stephen D. Atkinson, Robert W. Hunter, Michael Allison, Andrew D. Austin , et al. · 2023

Summary Background The prevalence, prediction and impact of acute kidney injury (AKI) in alcohol‐related hepatitis (AH) is uncertain. Aims We aimed to determine AKI incidence; association with mortality; evaluate serum biomarkers and the m…

Psychosocial and Pharmacological Therapies to Reduce Alcohol Consumption in Severe Alcohol-Related Hepatitis Patients: A Case Report Open

Humza Awan, Nikhil Vergis · 2023

Alcohol-related hepatitis (ARH) is an inflammatory liver disease caused by excessive alcohol intake over time. This represents a major health burden with a high mortality and poor prognosis. Reducing alcohol consumption is key to improving…

The Liverpool alcohol‐related liver disease algorithm identifies twice as many emergency admissions compared to standard methods when applied to Hospital Episode Statistics for England Open

Ashwin Dhanda, Keith Bodger, Steve Hood, Clive Henn, Michael Allison , et al. · 2022

Summary Background Emergency admissions in England for alcohol‐related liver disease (ArLD) have increased steadily for decades. Statistics based on administrative data typically focus on the ArLD‐specific code as the primary diagnosis and…

Visualising harms in publications of randomised controlled trials: consensus and recommendations Open

Rachel Phillips, Suzie Cro, Graham Wheeler, Simon Bond, Tim P. Morris , et al. · 2022

Objective To improve communication of harm in publications of randomised controlled trials via the development of recommendations for visually presenting harm outcomes. Design Consensus study. Setting 15 clinical trials units registered wi…

IL-1 Signal Inhibition In Alcoholic Hepatitis (ISAIAH): a study protocol for a multicentre, randomised, placebo-controlled trial to explore the potential benefits of canakinumab in the treatment of alcoholic hepatitis Open

Nikhil Vergis, Vaibhav B. Patel, K. Bogdanowicz, Justyna Czyzewska-Khan, Francesca Fiorentino , et al. · 2021

Multi-Arm Trial of Inflammatory Signal Inhibitors (MATIS) for Hospitalised Patients with Mild or Moderate COVID-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomised Controlled Trial Open

Asad Charania, Nikhil Vergis, Rachel Phillips, Victoria Cornelius, Alexia Katsarou , et al. · 2021

Introduction: Severe COVID-19 pneumonia is characterised by respiratory and multi-organ failure in the context of marked systemic inflammation. This hyperinflammatory syndrome is reflected by the elevation of several inflammatory molecules…

ATU-7 Incident acute kidney injury has a worse prognosis than baseline in severe alcoholic hepatitis Open

Luke D. Tyson, Professor Mark Thursz, Ewan Forrest, Michael Allison, Nikhil Vergis , et al. · 2021

Introduction Alcoholic hepatitis (AH) is the most severe alcohol-related liver disease. Acute kidney injury (AKI) is associated with increased mortality. AKI may be present at the time of presentation (baseline) or develop subsequently (in…

P032 Increasing burden of alcohol-related liver disease in the UK associated with the coronavirus pandemic Open

Ashwin Dhanda, Michael Allison, Keith Bodger, Ewan Forrest, Steve Hood , et al. · 2021

During the first UK national coronavirus pandemic lockdown (Mar-Jul 2020), alcohol sales increased 30% in supermarkets. Surveys reported that 20% of people increased their alcohol consumption and numbers of high-risk drinkers increased by…

Rapid, non-invasive measurement of gastric emptying rate using transcutaneous fluorescence spectroscopy Open

Aaron M. Lett, Alexandra Lim, Charlotte Skinner, James Maurice, Nikhil Vergis , et al. · 2021

Gastric emptying rate (GER) signifies the rate at which the stomach empties following ingestion of a meal and is relevant to a wide range of clinical conditions. GER also represents a rate limiting step in small intestinal absorption and s…

Multi-arm Trial of Inflammatory Signal Inhibitors (MATIS) for hospitalised patients with mild or moderate COVID-19 pneumonia: a structured summary of a study protocol for a randomised controlled trial Open

Nikhil Vergis, Rachel Phillips, Victoria Cornelius, Alexia Katsarou, Taryn Youngstein , et al. · 2021

Multi-arm Trial of Inflammatory Signal Inhibitors (MATIS) for Hospitalised Patients with Mild or Moderate COVID-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomised Controlled Trial Open

Nikhil Vergis, Rachel Phillips, Victoria Cornelius, Alexia Katsarou, Taryn Youngstein , et al. · 2021

The primary objective of MATIS is to determine the efficacy of ruxolitinib (RUX) or fostamatinib (FOS) compared to standard of care (SOC) with respect to reducing the proportion of hospitalised patients progressing from mild or moderate to…

Mitochondrial dysfunction and liver disease: role, relevance, and potential for therapeutic modulation Open

Paul Middleton, Nikhil Vergis · 2021

Mitochondria are key organelles involved in energy production as well as numerous metabolic processes. There is a growing interest in the role of mitochondrial dysfunction in the pathogenesis of common chronic diseases as well as in cancer…

Supplementary document for Rapid, non-invasive measurement of gastric emptying rate using transcutaneous fluorescence spectroscopy - 5247253.pdf Open

Aaron M. Lett, Alexandra Lim, Charlotte Skinner, James Maurice, Nikhil Vergis , et al. · 2021

Supplementary Figures and Table

P204 Mitochondrial dysfunction may explain innate immunoparesis and susceptibility to infection of patients with alcoholic hepatitis Open

Paul Middleton, Mark Thursz, Nikhil Vergis · 2021

Background Alcoholic hepatitis (AH) is the most florid form of alcohol related liver disease. Infection develops in 50% of patients and is strongly associated with mortality. Innate immune paresis is recognised in this condition, but mecha…

In Severe Alcoholic Hepatitis, Serum Keratin-18 Fragments Are Diagnostic, Prognostic, and Theragnostic Biomarkers Open

Stephen R. Atkinson, Jane I. Grove, Stephanie Liebig, Stuart Astbury, Nikhil Vergis , et al. · 2020

INTRODUCTION: Up to 40% of patients with severe alcoholic hepatitis (AH) die within 6 months of presentation, making prompt diagnosis and appropriate treatment essential. We determined the associations between serum keratin-18 (K18) and hi…

Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences Open

James Maurice, Aaron M. Lett, Charlotte Skinner, Alexandra Lim, M Richardson , et al. · 2020

Effect of COVID-19 lockdown on alcohol consumption in patients with pre-existing alcohol use disorder Open

Jin Un Kim, Amir Majid, R. Judge, Peter Crook, Rooshi Nathwani , et al. · 2020

Letter: liver disease and COVID‐19—not the perfect storm Open

Rooshi Nathwani, Sujit Mukherjee, Roberta Forlano, Benjamin H. Mullish, Nikhil Vergis , et al. · 2020

LINKED CONTENT This article is linked to Garrido et al papers. To view these articles, visit https://doi.org/10.1111/apt.15813 and https://doi.org/10.1111/apt.15886 .

Issue Information Open

K Inada, H Kazumori, Jingjing Yuan, Changsheng Zhang, Joseph T. Sparks , et al. · 2020

No benefi t of continuing vs stopping 5-aminosalicylates in patients

Trace element deficiency is highly prevalent and associated with infection and mortality in patients with alcoholic hepatitis Open

Ashwin Dhanda, Stephen R. Atkinson, Nikhil Vergis, Doyo Gragn Enki, Andrew Fisher , et al. · 2020

Summary Background Malnutrition is common in patients with alcohol‐related liver disease and is associated with outcome in patients with alcoholic hepatitis. Trace elements (cobalt, copper, iron, selenium and zinc) are micronutrients essen…

Intestinal permeability and bacterial translocation in patients with liver disease, focusing on alcoholic aetiology: methods of assessment and therapeutic intervention Open

Charlotte Skinner, Alex J. Thompson, Mark Thursz, Julian R. Marchesi, Nikhil Vergis · 2020

Increased bacterial translocation (BT) across the gut barrier due to greater intestinal permeability (IP) is seen across a range of conditions, including alcohol-related liver disease (ArLD). The phenomenon of BT may contribute to both the…

Assessment and Management of Infection in Alcoholic Hepatitis Open

Nikhil Vergis, Stephen R. Atkinson, Mark Thursz · 2019

Severe alcoholic hepatitis (SAH) is a condition characterized by jaundice and liver failure that develops after heavy and prolonged alcohol consumption. Infection frequently complicates the natural history of the disease and is independent…

Obesity in acute alcoholic hepatitis increases morbidity and mortality Open

Richard Parker, Seung Ju Kim, Gene Y. Im, Jonathan Nahas, Balraj Dhesi , et al. · 2019

PS-174-Serum bile acid profiles distinguish severe alcoholic hepatitis from decompensated alcohol-related cirrhosis Open

Luke D. Tyson, Simon Atkinson, Alexandros Pechlivanis, Elaine Holmes, Nikhil Vergis , et al. · 2019

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