Nikho Hizon
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View article: DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes
DNA methylation signatures of youth-onset type 2 diabetes and exposure to maternal diabetes Open
Objective Youth-onset type 2 diabetes (T2D) is physiologically distinct from adult-onset, but it is not clear how the two diseases differ at a molecular level. In utero exposure to maternal type 2 diabetes (T2D) is known to be a specific r…
View article: Novel DNA methylation changes in mouse lungs associated with chronic smoking
Novel DNA methylation changes in mouse lungs associated with chronic smoking Open
Smoking is a potent cause of asthma exacerbations, chronic obstructive pulmonary disease (COPD) and many other health defects, and changes in DNA methylation (DNAm) have been identified as a potential link between smoking and these health …
View article: Emergence and spread of SARS-CoV-2 variants of concern in Canada: a retrospective analysis from clinical and wastewater data
Emergence and spread of SARS-CoV-2 variants of concern in Canada: a retrospective analysis from clinical and wastewater data Open
Background The spread of SARS-CoV-2 has been studied at unprecedented levels worldwide. In jurisdictions where molecular analysis was performed on large scales, the emergence and competition of numerous SARS-CoV-2lineages have been observe…
View article: Preparing for Mpox Resurgence: Surveillance Lessons From Outbreaks in Toronto, Canada
Preparing for Mpox Resurgence: Surveillance Lessons From Outbreaks in Toronto, Canada Open
Background With many global jurisdictions, Toronto, Canada, experienced an mpox outbreak in spring/summer 2022. Cases declined following implementation of a large vaccination campaign. A surge in early 2023 led to speculation that asymptom…
View article: Novel DNA methylation changes in mouse lungs associated with heavy smoking
Novel DNA methylation changes in mouse lungs associated with heavy smoking Open
Smoking is a potent cause of asthma, chronic obstructive pulmonary disease (COPD) and many other health defects, and changes in DNA methylation (DNAm) have been identified as a potential link between smoking and these health outcomes. Howe…
View article: Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at <i>Cyp1a1</i> upon exposure later in life
Early-life exposure to cigarette smoke primes lung function and DNA methylation changes at <i>Cyp1a1</i> upon exposure later in life Open
Here, we isolated effects of prenatal from early postnatal cigarette smoke and showed that exposure to cigarette smoke early in life causes changes in offspring DNA methylation at Cyp1a1 that last through early adulthood but not into late …
View article: Early life exposure to cigarette smoke primes lung function and DNA methylation changes at<i>Cyp1a1</i>upon exposure later in life
Early life exposure to cigarette smoke primes lung function and DNA methylation changes at<i>Cyp1a1</i>upon exposure later in life Open
Prenatal and early life exposure to cigarette smoke (CS) have repeatedly been shown to induce stable, long-term changes in DNA methylation (DNAm) in offspring. It has been hypothesized that these changes might be functionally related to th…
View article: Emergence and Spread of SARS-CoV-2 Variants of Concern in Canada: a Retrospective Analysis from Clinical and Wastewater Data
Emergence and Spread of SARS-CoV-2 Variants of Concern in Canada: a Retrospective Analysis from Clinical and Wastewater Data Open
The spread of SARS-CoV-2 has been studied at unprecedented levels worldwide. In jurisdictions where molecular analysis was performed on large scales, the emergence and competition of numerous SARS-CoV-2 lineages has been observed in near r…
View article: Exploration of wastewater surveillance for Monkeypox virus
Exploration of wastewater surveillance for Monkeypox virus Open
The sudden emergence and spread of Monkeypox in non-endemic parts of the world is currently not well understood. Infections are often mis-diagnosed and surveillance strategies are scarce. Wastewater-based surveillance (WBS) of human Monkey…