Niki L. Reynaert
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View article: Multipotent adult progenitor cell therapy: Effect of timing and frequency on lung health in preterm lambs during inflammation
Multipotent adult progenitor cell therapy: Effect of timing and frequency on lung health in preterm lambs during inflammation Open
View article: Adding Weight to the Evidence: <scp>MMP</scp> ‐9 as a Predictor of <scp>COPD</scp> Development
Adding Weight to the Evidence: <span>MMP</span> ‐9 as a Predictor of <span>COPD</span> Development Open
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View article: Insights into interstitial lung disease pathogenesis
Insights into interstitial lung disease pathogenesis Open
This review summarises some of the key features of interstitial lung diseases (ILDs) from a translational science point of view and brings insights into potential therapeutic options. Genetic predisposition and environmental factors like s…
View article: Multipotent Adult Progenitor Cell Therapy: Effect of Timing and Frequency on Lung Health in Preterm Lambs During Inflammation
Multipotent Adult Progenitor Cell Therapy: Effect of Timing and Frequency on Lung Health in Preterm Lambs During Inflammation Open
View article: Identification of Defined Molecular Subgroups on the Basis of Immunohistochemical Analyses and Potential Therapeutic Vulnerabilities of Pulmonary Carcinoids
Identification of Defined Molecular Subgroups on the Basis of Immunohistochemical Analyses and Potential Therapeutic Vulnerabilities of Pulmonary Carcinoids Open
An OTP, ASCL1, and HNF1A IHC panel enables the identification of molecular-defined pulmonary carcinoid subgroups with distinct clinical phenotypes and diverging therapeutic vulnerabilities that require further prospective evaluation.
View article: Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs
Multipotent adult progenitor cells prevent functional impairment and improve development in inflammation driven detriment of preterm ovine lungs Open
In conclusion, prenatal inflammation sensitizes the underdeveloped preterm lung to subsequent postnatal inflammation, resulting in injury, disturbed development and functional impairment. MAPC therapy partially prevents these changes and i…
View article: The importance of translational science within the respiratory field
The importance of translational science within the respiratory field Open
The Translational Science Working Group at the European Respiratory Society (ERS) aims to bridge the gap between basic and clinical science by providing a platform where scientists, clinicians and experts in the respiratory field can activ…
View article: Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells
Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells Open
View article: ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly
ERS International Congress 2023: highlights from the Basic and Translational Sciences Assembly Open
Early career members of Assembly 3 (Basic and Translational Sciences) of the European Respiratory Society (ERS) summarise the key messages discussed during six selected sessions that took place at the ERS International Congress 2023 in Mil…
View article: Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system x<sub>C</sub><sup>−</sup>
Glutaredoxin attenuates glutathione levels via deglutathionylation of Otub1 and subsequent destabilization of system x<sub>C</sub><sup>−</sup> Open
Glutathione (GSH) is a critical component of the cellular redox system that combats oxidative stress. The glutamate-cystine antiporter, system x C − , is a key player in GSH synthesis that allows for the uptake of cystine, the rate-limitin…
View article: The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD
The AGE-RAGE Axis and the Pathophysiology of Multimorbidity in COPD Open
Chronic obstructive pulmonary disease (COPD) is a disease of the airways and lungs due to an enhanced inflammatory response, commonly caused by cigarette smoking. Patients with COPD are often multimorbid, as they commonly suffer from multi…
View article: Polymer film-based microwell array platform for long-term culture and research of human bronchial organoids
Polymer film-based microwell array platform for long-term culture and research of human bronchial organoids Open
The culture of lung organoids relies on drops of basement membrane matrices. This comes with limitations, for example, concerning the microscopic monitoring and imaging of the organoids in the drops. Also, the culture technique is not easi…
View article: ERS International Congress 2022: highlights from the Basic and Translational Science Assembly
ERS International Congress 2022: highlights from the Basic and Translational Science Assembly Open
In this review, the Basic and Translational Science Assembly of the European Respiratory Society provides an overview of the 2022 International Congress highlights. We discuss the consequences of respiratory events from birth until old age…
View article: IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors’ Function
IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors’ Function Open
Chronic obstructive pulmonary disease (COPD) is characterized by a persistent inflammatory state in the lungs and defective tissue repair. Although the inflammatory response in patients with COPD is well characterized and known to be exagg…
View article: Biomarker-based clustering of patients with chronic obstructive pulmonary disease
Biomarker-based clustering of patients with chronic obstructive pulmonary disease Open
Rationale COPD has been associated repeatedly with single biomarkers of systemic inflammation, ignoring the complexity of inflammatory pathways. This study aimed to cluster patients with COPD based on systemic markers of inflammatory proce…
View article: Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models
Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models Open
Exposure to cigarette smoke (CS) is the primary risk factor for developing chronic obstructive pulmonary disease. The impact of CS exposure on the molecular mechanisms involved in mitochondrial quality control in airway epithelial cells is…
View article: Time to Shift Focus from Oxidative Stress to Redox Regulation in COPD
Time to Shift Focus from Oxidative Stress to Redox Regulation in COPD Open
Chronic obstructive pulmonary disease (COPD) is a non-communicable chronic disease that is top-ranking with respect to mortality and morbidity rates, posing an enormous burden on patients, caregivers and societies at large [...]
View article: Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies
Redox Dysregulation in Aging and COPD: Role of NOX Enzymes and Implications for Antioxidant Strategies Open
With a rapidly growing elderly human population, the incidence of age-related lung diseases such as chronic obstructive pulmonary disease (COPD) continues to rise. It is widely believed that reactive oxygen species (ROS) play an important …
View article: Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2
Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2 Open
View article: Alterations in plasma hyaluronic acid in patients with clinically stable COPD versus (non)smoking controls
Alterations in plasma hyaluronic acid in patients with clinically stable COPD versus (non)smoking controls Open
View article: Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease
Longitudinal changes in total and regional body composition in patients with chronic obstructive pulmonary disease Open
Background and objective Low fat‐free mass (FFM) is common in patients with chronic obstructive pulmonary disease (COPD) and contributes to morbidity and mortality. Few studies have evaluated longitudinal changes in body composition in pat…
View article: Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema
Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema Open
Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial host defense to nonmicrobial…
View article: Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility?
Glutathione S-transferases and their implications in the lung diseases asthma and chronic obstructive pulmonary disease: Early life susceptibility? Open
Our lungs are exposed daily to airborne pollutants, particulate matter, pathogens as well as lung allergens and irritants. Exposure to these substances can lead to inflammatory responses and may induce endogenous oxidant production, which …
View article: Glutathionylation chemistry promotes interleukin‐1 beta‐mediated glycolytic reprogramming and pro‐inflammatory signaling in lung epithelial cells
Glutathionylation chemistry promotes interleukin‐1 beta‐mediated glycolytic reprogramming and pro‐inflammatory signaling in lung epithelial cells Open
Glycolysis is a well‐known process by which metabolically active cells, such as tumor or immune cells meet their high metabolic demands. Previously, our laboratory has demonstrated that in airway epithelial cells, the pleiotropic cytokine,…
View article: Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells
Sequential Exposure to Antenatal Microbial Triggers Attenuates Alveolar Growth and Pulmonary Vascular Development and Impacts Pulmonary Epithelial Stem/Progenitor Cells Open
Perinatal inflammatory stress is strongly associated with adverse pulmonary outcomes after preterm birth. Antenatal infections are an essential perinatal stress factor and contribute to preterm delivery, induction of lung inflammation and …
View article: Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease
Downregulation of epithelial DUOX1 in chronic obstructive pulmonary disease Open
Chronic obstructive pulmonary disease (COPD) is a chronic respiratory disease characterized by small airway remodeling and alveolar emphysema due to environmental stresses such as cigarette smoking (CS). Oxidative stress is commonly implic…
View article: Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero
Chorioamnionitis induces changes in ovine pulmonary endogenous epithelial stem/progenitor cells in utero Open
View article: Early origins of lung disease: towards an interdisciplinary approach
Early origins of lung disease: towards an interdisciplinary approach Open
The prenatal and perinatal environments can have profound effects on the development of chronic inflammatory diseases. However, mechanistic insight into how the early-life microenvironment can impact upon development of the lung and immune…
View article: Biomarker-Based Clustering of Patients with COPD and the Association with Lung Function, Dyspnea and Health Status
Biomarker-Based Clustering of Patients with COPD and the Association with Lung Function, Dyspnea and Health Status Open
View article: Skin autofluorescence: early sign of lung function deterioration?
Skin autofluorescence: early sign of lung function deterioration? Open
The relationship between SAF and FEV1, D LCO and X 5, independent of COPD or diabetes. Will individuals with raised SAF and subclinical lung function alterations develop disease? What mecha…