Niklas Bachmann
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View article: Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions
Three-dimensional genomic mapping of human pancreatic tissue reveals striking multifocality and genetic heterogeneity in precancerous lesions Open
Pancreatic intraepithelial neoplasia (PanIN) is a precursor to pancreatic cancer and represents a critical opportunity for cancer interception. However, the number, size, shape, and connectivity of PanINs in human pancreatic tissue samples…
View article: Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods
Measuring the latent reservoir for HIV-1: Quantification bias in near full-length genome sequencing methods Open
Antiretroviral therapy (ART) effectively inhibits HIV-1 replication but is not curative due to the persistence of a latent viral reservoir in resting CD4 + T cells. This reservoir is a major barrier to cure. Sequencing studies have reveale…
View article: Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy
Complex decay dynamics of HIV virions, intact and defective proviruses, and 2LTR circles following initiation of antiretroviral therapy Open
Significance In persons living with HIV-1 who start antiretroviral therapy, virus in the blood decreases rapidly to below the detection limit. The decrease occurs in two phases: a rapid initial decrease in the first weeks, followed by a se…
View article: Mouse Homologue of Human HLA-DO Does Not Preempt Autoimmunity but Controls Murine Gammaherpesvirus MHV68
Mouse Homologue of Human HLA-DO Does Not Preempt Autoimmunity but Controls Murine Gammaherpesvirus MHV68 Open
H2-O (human HLA-DO) is a relatively conserved nonclassical MHC class II (MHCII)–like molecule. H2-O interaction with human HLA-DM edits the repertoire of peptides presented to TCRs by MHCII. It was long hypothesized that human HLA-DM inhib…
View article: Generation of αGFP-nanobodies suitable for super-resolution imaging of nuclear proteins
Generation of αGFP-nanobodies suitable for super-resolution imaging of nuclear proteins Open
The emergence of single molecule localization microscopy (SMLM) techniques made the imaging of cells at resolutions far beyond the diffraction barrier possible. However, the usual approach of tagging a protein of interest (PoI) with a prim…