Niklas Domdei
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View article: Assessment of an algorithm-based combination device for objective and subjective refraction: accuracy and efficiency across examiner experience levels
Assessment of an algorithm-based combination device for objective and subjective refraction: accuracy and efficiency across examiner experience levels Open
The tested combination refraction device provides reliable and efficient objective and subjective refraction measurements across trained and untrained examiners.
View article: Synchronization of visual perception within the human fovea
Synchronization of visual perception within the human fovea Open
The human brain constructs a model of the world by processing sensory signals with distinct temporal characteristics that may differ in generation and transmission speed within a single sensory modality. To perceive simultaneous events as …
View article: Assessing visual performance during intense luminance changes in virtual reality
Assessing visual performance during intense luminance changes in virtual reality Open
During indoor-outdoor transitions humans encounter luminance changes beyond the functional range of the photoreceptors, leaving the individual at risk of overlooking harmful low-contrast objects until adaptation processes re-enable optimal…
View article: Foveal neural adaptation to optically induced contrast reduction
Foveal neural adaptation to optically induced contrast reduction Open
Contrast processing is suggested to interact with eye growth and myopia development. A novel contrast-reducing myopia control lens design decreases image contrast and was shown to slow myopia progression. Limited insights exist regarding n…
View article: Neural contrast sensitivity is not affected by myopic blur
Neural contrast sensitivity is not affected by myopic blur Open
Purpose The prevalence of myopia is increasing worldwide, accompanied by an increase of potentially under-corrected myopes. Because the neural pathways processing the retinal image are prone to adaptation in relation to the retinal image q…
View article: Influence of Aberration-Free, Narrowband Light on the Choroidal Thickness and Eye Length
Influence of Aberration-Free, Narrowband Light on the Choroidal Thickness and Eye Length Open
This study helps in understanding if light chromaticity alone is a sufficient regulator of eye growth.
View article: Assessing visual performance during intense luminance changes in virtual reality
Assessing visual performance during intense luminance changes in virtual reality Open
Summary During indoor-outdoor transitions humans encounter luminance changes beyond the functional range of the photoreceptors, leaving the individual at risk of overlooking harmful low-contrast objects until adaptation processes re-enable…
View article: Cone Density Is Correlated to Outer Segment Length and Retinal Thickness in the Human Foveola
Cone Density Is Correlated to Outer Segment Length and Retinal Thickness in the Human Foveola Open
Using optical coherence tomography-derived measurements of OSL enables to estimate CDC cone density and two-dimensional foveal cone density maps for example in patient eyes unsuitable for adaptive optics imaging. Furthermore, the observati…
View article: Interference based aberration-free chromatic stimulator for human myopia research
Interference based aberration-free chromatic stimulator for human myopia research Open
Previous studies showed an impact of the light spectrum on ocular growth. It is unclear whether the eye reacts to the light chromaticity or to the defocus induced by the longitudinal chromatic aberration (LCA). This study investigated the …
View article: The Relationship Between Visual Sensitivity and Eccentricity, Cone Density and Outer Segment Length in the Human Foveola
The Relationship Between Visual Sensitivity and Eccentricity, Cone Density and Outer Segment Length in the Human Foveola Open
Small-spot sensitivity thresholds in healthy retinas will help to establish the range of normal foveolar function in cell-targeted vision testing. Because of the high reproducibility in replicate testing, threshold variability not explaine…
View article: Human gaze is systematically offset from the center of cone topography
Human gaze is systematically offset from the center of cone topography Open
Summary The small physical depression of the human retina, the fovea, is the retinal locus of prime visual resolution, achieved by a peaking topography of the light sensitive cone photoreceptor outer segments 1–3 and a post-receptor wiring…
View article: Retinal factors of visual sensitivity in the human fovea
Retinal factors of visual sensitivity in the human fovea Open
Humans direct their gaze towards visual objects of interest such that the retinal images of fixated objects fall onto the fovea, a small anatomically and physiologically specialized region of the retina displaying highest visual fidelity. …
View article: Effect of cone spectral topography on chromatic detection sensitivity
Effect of cone spectral topography on chromatic detection sensitivity Open
The spatial and spectral topography of the cone mosaic set the limits for detection and discrimination of chromatic sinewave gratings. Here, we sought to compare the spatial characteristics of mechanisms mediating hue perception against th…
View article: Eye tracking-based estimation and compensation of chromatic offsets for multi-wavelength retinal microstimulation with foveal cone precision
Eye tracking-based estimation and compensation of chromatic offsets for multi-wavelength retinal microstimulation with foveal cone precision Open
Multi-wavelength ophthalmic imaging and stimulation of photoreceptor cells require consideration of chromatic dispersion of the eye, manifesting in longitudinal and transverse chromatic aberrations. Contemporary image-based techniques to m…
View article: Eye tracking-based estimation and compensation of chromatic offsets for multi-wavelength retinal microstimulation with foveal cone precision
Eye tracking-based estimation and compensation of chromatic offsets for multi-wavelength retinal microstimulation with foveal cone precision Open
Multi-wavelength ophthalmic imaging and stimulation of photoreceptor cells requires consideration of chromatic dispersion of the eye, manifesting in longitudinal and transverse chromatic aberrations. Current image-based techniques to measu…
View article: Ultra-high contrast retinal display system for single photoreceptor psychophysics
Ultra-high contrast retinal display system for single photoreceptor psychophysics Open
Due to the enormous dynamic range of human photoreceptors in response to light, studying their visual function in the intact retina challenges the stimulation hardware, specifically with regard to the displayable luminance contrast. The ad…
View article: MINIMAL OPTICAL COHERENCE TOMOGRAPHY B-SCAN DENSITY FOR RELIABLE DETECTION OF INTRARETINAL AND SUBRETINAL FLUID IN MACULAR DISEASES
MINIMAL OPTICAL COHERENCE TOMOGRAPHY B-SCAN DENSITY FOR RELIABLE DETECTION OF INTRARETINAL AND SUBRETINAL FLUID IN MACULAR DISEASES Open
Purpose: To determine the minimal optical coherence tomography B-scan density for reliable detection of intraretinal and subretinal fluid. Methods: Spectral domain optical coherence tomography raster scanning (Spectralis; Heidelberg Engine…
View article: Benefits of retinal image motion at the limits of spatial vision
Benefits of retinal image motion at the limits of spatial vision Open
Even during fixation, our eyes are constantly in motion, creating an ever-changing signal in each photoreceptor. Neuronal processes can exploit such transient signals to serve spatial vision, but it is not known how our finest visual acuit…
View article: OCT Angiography–Based Detection and Quantification of the Neovascular Network in Exudative AMD
OCT Angiography–Based Detection and Quantification of the Neovascular Network in Exudative AMD Open
Optical coherence tomography angiography-based measurements of the new vessel complex in neovascular AMD are feasible with interreader agreement comparable with the values obtained for FA. The results underscore the potential of OCT-A as a…