Niklas Ermann
YOU?
Author Swipe
View article: Molecular mechanisms of condensate modulation from energy-dominance analysis
Molecular mechanisms of condensate modulation from energy-dominance analysis Open
Biomolecular condensates in cells underpin cellular organization but have also been implicated in disease progression. As a result, modulation of condensate formation is becoming a path of interest to ameliorate biological malfunction. How…
View article: Linking modulation of bio-molecular phase behaviour with collective interactions
Linking modulation of bio-molecular phase behaviour with collective interactions Open
Bio-molecular condensates formed in the cytoplasm of cells are increasingly recognised as key spatiotemporal organisers of living matter, and are implicated in a wide range of functional or pathological processes. This discovery opens up a…
View article: Simultaneous identification of viruses and viral variants with programmable DNA nanobait
Simultaneous identification of viruses and viral variants with programmable DNA nanobait Open
View article: The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus**
The Chromatin Regulator HMGA1a Undergoes Phase Separation in the Nucleus** Open
The protein high mobility group A1 (HMGA1) is an important regulator of chromatin organization and function. However, the mechanisms by which it exerts its biological function are not fully understood. Here, we report that the HMGA isoform…
View article: Simultaneous identification of viruses and viral variants with programmable DNA nanobait
Simultaneous identification of viruses and viral variants with programmable DNA nanobait Open
Respiratory infections are the major cause of death from infectious disease worldwide. Multiplexed diagnostic approaches are essential as many respiratory viruses have indistinguishable symptoms. We created self-assembled DNA nanobait that…
View article: The chromatin regulator HMGA1a undergoes phase separation in the nucleus
The chromatin regulator HMGA1a undergoes phase separation in the nucleus Open
The protein high mobility group A1 (HMGA1) is an important regulator of chromatin organization and function. However, the mechanisms by which it exerts its biological function are not fully understood. Here, we report that the HMGA isoform…
View article: Research data supporting "Dynamics of driven polymer transport through a nanopore"
Research data supporting "Dynamics of driven polymer transport through a nanopore" Open
This research data supports “Dynamics of driven polymer transport through a nanopore” which is published in “Nature Physics”.\nThe data set contains the data for each figure in the paper in the corresponding folder (Figure 1 – Figure 5). I…
View article: Dynamics of driven polymer transport through a nanopore
Dynamics of driven polymer transport through a nanopore Open
View article: Image Encoding Using Multi‐Level DNA Barcodes with Nanopore Readout
Image Encoding Using Multi‐Level DNA Barcodes with Nanopore Readout Open
Deoxyribonucleic acid (DNA) nanostructure‐based data encoding is an emerging information storage mode, offering rewritable, editable, and secure data storage. Herein, a DNA nanostructure‐based storage method established on a solid‐state na…
View article: Nanopore-Based Readout of Encoded DNA Nanostructures
Nanopore-Based Readout of Encoded DNA Nanostructures Open
Nanopore sensing is a powerful technique for the detection and study of single molecules. The underlying resistive pulse principle relies on molecules modulating an ionic current as they pass through a nanoscale constriction between two re…
View article: Multiplexed DNA Identification Using Site Specific dCas9 Barcodes and Nanopore Sensing
Multiplexed DNA Identification Using Site Specific dCas9 Barcodes and Nanopore Sensing Open
Decorating double-stranded DNA with dCas9 barcodes to identify characteristic short sequences provides an alternative to fully sequencing DNA samples for rapid and highly specific analysis of a DNA sample. Solid state nanopore sensors are …
View article: Current Enhancement in Solid-State Nanopores Depends on Three-Dimensional DNA Structure
Current Enhancement in Solid-State Nanopores Depends on Three-Dimensional DNA Structure Open
The translocation of double-stranded DNA through a solid-state nanopore may either decrease or increase the ionic current depending on the ionic concentration of the surrounding solution. Below a certain crossover ionic concentration, the …
View article: Bayesian inference for nanopore data analysis
Bayesian inference for nanopore data analysis Open
Nanopore sensors detect the substructure of individual molecules from modulations in an ion current as molecules pass through them. In this work, we present the classification of features in the substructure as a case study to illustrate t…
View article: Digital Data Storage Using DNA Nanostructures and Solid-State Nanopores
Digital Data Storage Using DNA Nanostructures and Solid-State Nanopores Open
Solid-state nanopores are powerful tools for reading the three-dimensional shape of molecules, allowing for the translation of molecular structure information into electric signals. Here, we show a high-resolution integrated nanopore syste…
View article: QuipuNet: Convolutional Neural Network for Single-Molecule Nanopore Sensing
QuipuNet: Convolutional Neural Network for Single-Molecule Nanopore Sensing Open
Nanopore sensing is a versatile technique for the analysis of molecules on the single-molecule level. However, extracting information from data with established algorithms usually requires time-consuming checks by an experienced researcher…
View article: Controlling the Conformation of Double-Stranded DNA during Translocation through a Glass Nanocapillary
Controlling the Conformation of Double-Stranded DNA during Translocation through a Glass Nanocapillary Open
View article: Probing the salt dependence of the torsional stiffness of DNA by multiplexed magnetic torque tweezers
Probing the salt dependence of the torsional stiffness of DNA by multiplexed magnetic torque tweezers Open
The mechanical properties of DNA fundamentally constrain and enable the storage and transmission of genetic information and its use in DNA nanotechnology. Many properties of DNA depend on the ionic environment due to its highly charged bac…