Niklas Sandler
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View article: Automated 3D Printing-Based Non-Sterile Compounding Technology for Pediatric Corticosteroid Dosage Forms in a Health System Pharmacy Setting
Automated 3D Printing-Based Non-Sterile Compounding Technology for Pediatric Corticosteroid Dosage Forms in a Health System Pharmacy Setting Open
Background: Pharmaceutical compounding remains a predominantly manual process with limited innovation, particularly in non-sterile applications. This study explores the implementation of an automated compounding platform based on 3D printi…
View article: Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets
Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets Open
Pharmacy compounding, the art and science of preparing customized medications to meet individual patient needs, is in a verge of transformation. Traditional methods of compounding often involve manual and time-consuming processes, presenti…
View article: Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing
Personalizing oral delivery of nanoformed piroxicam by semi-solid extrusion 3D printing Open
Semi-solid extrusion (SSE) 3D printing enables flexible designs and dose sizes to be printed on demand and is a suitable tool for fabricating personalized dosage forms. Controlled Expansion of Supercritical Solution (CESS®) is a particle s…
View article: Compounding Tailored Veterinary Chewable Tablets Close to the Point-of-Care by Means of 3D Printing
Compounding Tailored Veterinary Chewable Tablets Close to the Point-of-Care by Means of 3D Printing Open
Certain patient populations receive insufficient medicinal treatment due to a lack of commercially available products. The number of approved veterinary products is limited, making animals a patient population with suboptimal medicinal tre…
View article: Semi-solid extrusion 3D printing of tailored ChewTs for veterinary use - A focus on spectrophotometric quantification of gabapentin
Semi-solid extrusion 3D printing of tailored ChewTs for veterinary use - A focus on spectrophotometric quantification of gabapentin Open
Currently, there are a few or none marketed gabapentin veterinary products, leading to treatment with compounded dosage forms or off-label use of human-marketed products. With the said approaches, there are significant risks of preparation…
View article: 3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers
3D-Printed Veterinary Dosage Forms—A Comparative Study of Three Semi-Solid Extrusion 3D Printers Open
Currently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for …
View article: 3D-Printed Veterinary Dosage Forms – A Comparative Study of Three Semi-Solid Extrusion Printers
3D-Printed Veterinary Dosage Forms – A Comparative Study of Three Semi-Solid Extrusion Printers Open
Currently, the number of approved veterinary medicines are limited, and human medications are used off-label. These approved human medications are of too high potencies for a cat or a small dog breed. Therefore, there is a dire demand for …
View article: Benefits and Prerequisites Associated with the Adoption of Oral 3D-Printed Medicines for Pediatric Patients: A Focus Group Study among Healthcare Professionals
Benefits and Prerequisites Associated with the Adoption of Oral 3D-Printed Medicines for Pediatric Patients: A Focus Group Study among Healthcare Professionals Open
The utilization of three-dimensional (3D) printing technologies as innovative manufacturing methods for drug products has recently gained growing interest. From a technological viewpoint, proof-of-concept on the performance of different pr…
View article: A Focus Group Study about Oral Drug Administration Practices at Hospital Wards—Aspects to Consider in Drug Development of Age-Appropriate Formulations for Children
A Focus Group Study about Oral Drug Administration Practices at Hospital Wards—Aspects to Consider in Drug Development of Age-Appropriate Formulations for Children Open
Oral drug administration to pediatric patients is characterized by a lack of age-appropriate drug products and the off-label use of medicines. However, drug administration practices at hospital wards is a scarcely studied subject. The aim …
View article: Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs
Stencil Printing—A Novel Manufacturing Platform for Orodispersible Discs Open
Stencil printing is a commonly used printing method, but it has not previously been used for production of pharmaceuticals. The aim of this study was to explore whether stencil printing of drug containing polymer inks could be used to manu…
View article: Bi-Layered Polymer Carriers with Surface Modification by Electrospinning for Potential Wound Care Applications
Bi-Layered Polymer Carriers with Surface Modification by Electrospinning for Potential Wound Care Applications Open
Polymeric wound dressings with advanced properties are highly preferred formulations to promote the tissue healing process in wound care. In this study, a combinational technique was investigated for the fabrication of bi-layered carriers …
View article: Oromucosal films: from patient centricity to production by printing techniques
Oromucosal films: from patient centricity to production by printing techniques Open
Introduction: Oromucosal films, comprising mucoadhesive buccal films (MBFs) and orodispersible films (ODFs), are considered patient-centric dosage forms. Target groups are patients with special needs. Various active pharmaceutical ingredie…
View article: Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets
Towards Printed Pediatric Medicines in Hospital Pharmacies: Comparison of 2D and 3D-Printed Orodispersible Warfarin Films with Conventional Oral Powders in Unit Dose Sachets Open
To date, the lack of age-appropriate medicines for many indications results in dose manipulation of commercially available dosage forms, commonly resulting in inaccurate doses. Various printing technologies have recently been explored in t…
View article: Three-Dimensional Printing of Wood-Derived Biopolymers: A Review Focused on Biomedical Applications
Three-Dimensional Printing of Wood-Derived Biopolymers: A Review Focused on Biomedical Applications Open
Wood-derived biopolymers have attracted great attention over the past few decades due to their abundant and versatile properties. The well-separated three main components, i.e., cellulose, hemicelluloses, and lignin, are considered signifi…
View article: Inkjet Printing of Drug-Loaded Mesoporous Silica Nanoparticles—A Platform for Drug Development
Inkjet Printing of Drug-Loaded Mesoporous Silica Nanoparticles—A Platform for Drug Development Open
Mesoporous silica nanoparticles (MSNs) have shown great potential in improving drug delivery of poorly water soluble (BCS class II, IV) and poorly permeable (BCS class III, IV) drugs, as well as facilitating successful delivery of unstable…
View article: Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems
Tailored Approaches in Drug Development and Diagnostics: From Molecular Design to Biological Model Systems Open
Approaches to increase the efficiency in developing drugs and diagnostics tools, including new drug delivery and diagnostic technologies, are needed for improved diagnosis and treatment of major diseases and health problems such as cancer,…
View article: Investigation of the powder flow behaviour of binary mixtures of microcrystalline celluloses and paracetamol
Investigation of the powder flow behaviour of binary mixtures of microcrystalline celluloses and paracetamol Open
The flow behaviour of binary mixtures of paracetamol and different grades of microcrystalline celluloses (Avicel® PH101, PH102 and PH200) was studied using a new testing method. The effect of physical characteristics of the powder includin…
View article: Perception of the Professional Knowledge of and Education on the Medical Technology Products among the Pharmacists in the Baltic and Nordic Countries—A Cross-Sectional Exploratory Study
Perception of the Professional Knowledge of and Education on the Medical Technology Products among the Pharmacists in the Baltic and Nordic Countries—A Cross-Sectional Exploratory Study Open
With increased development of medical technology (MT), new challenges emerge related to education and training of pharmacists and other healthcare specialists. Currently, only a few universities in the EU promote MT education and research.…
View article: Application of antibacterial coatings on resin composite implant materials using inkjet printing technology
Application of antibacterial coatings on resin composite implant materials using inkjet printing technology Open
Fiber-reinforced composite (FRC) implants have shown to be a favorable option as an implant material, compared to titanium, in terms of biocompatibility and mechanical properties. Furthermore, application of antibacterial coatings onto the…
View article: Evaluation of inhaler handling-errors, inhaler perception and preference with Spiromax, Easyhaler and Turbuhaler devices among healthy Finnish volunteers: a single site, single visit crossover study (Finhaler)
Evaluation of inhaler handling-errors, inhaler perception and preference with Spiromax, Easyhaler and Turbuhaler devices among healthy Finnish volunteers: a single site, single visit crossover study (Finhaler) Open
Introduction Correct inhaler technique and device preference are positively correlated with improved adherence and clinical outcomes. This study was designed to investigate inhaler technique mastery and device preference for three differen…