Nikolas Friedrich
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View article: Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development
Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development Open
Identifying HIV-1 envelope (Env) traits associated with neutralization cross-reactivity is crucial for vaccine design. Variable loops 1 and 2 (V1V2), positioned at the Env trimer apex, are key regions linked to neutralization. We describe …
View article: Assessing bnAb potency in the context of HIV-1 envelope conformational plasticity
Assessing bnAb potency in the context of HIV-1 envelope conformational plasticity Open
For use in prevention and treatment, HIV-1 broadly neutralizing antibodies (bnAbs) have to overcome Env conformational heterogeneity of viral quasispecies and neutralize with constant high potency. Comparative analysis of neutralization da…
View article: The XbnAb Cohort: 304 people with broadly neutralizing antibody activity to HIV-1
The XbnAb Cohort: 304 people with broadly neutralizing antibody activity to HIV-1 Open
Broadly neutralizing antibodies (bnAbs) recognizing a diversity of HIV-1 strains are widely thought to be essential for an HIV-1 vaccine. Extensive knowledge on bnAbs has been gained from studying natural HIV infection by following bnAb ev…
View article: Assessing immunogenicity barriers of the HIV-1 envelope trimer
Assessing immunogenicity barriers of the HIV-1 envelope trimer Open
Understanding the balance between epitope shielding and accessibility on HIV-1 envelope (Env) trimers is essential to guide immunogen selection for broadly neutralizing antibody (bnAb) based vaccines. To investigate the antigenic space of …
View article: Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies
Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies Open
The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an M…
View article: Author response: Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies
Author response: Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The HIV-1 gp120/gp41 trimer undergoes a se…
View article: Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies
Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies Open
The HIV-1 gp120/gp41 trimer undergoes a series of conformational changes in order to catalyze gp41-induced fusion of viral and cellular membranes. Here, we present the crystal structure of gp41 locked in a fusion intermediate state by an M…
View article: CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity
CD4 occupancy triggers sequential pre-fusion conformational states of the HIV-1 envelope trimer with relevance for broadly neutralizing antibody activity Open
During the entry process, the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) trimer undergoes a sequence of conformational changes triggered by both CD4 and coreceptor engagement. Resolving the conformation of thes…
View article: Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity
Distinct, IgG1-driven antibody response landscapes demarcate individuals with broadly HIV-1 neutralizing activity Open
Understanding pathways that promote HIV-1 broadly neutralizing antibody (bnAb) induction is crucial to advance bnAb-based vaccines. We recently demarcated host, viral, and disease parameters associated with bnAb development in a large HIV-…
View article: Development of a high-throughput bead based assay system to measure HIV-1 specific immune signatures in clinical samples
Development of a high-throughput bead based assay system to measure HIV-1 specific immune signatures in clinical samples Open
The monitoring and assessment of a broadly neutralizing antibody (bnAb) based HIV-1 vaccine require detailed measurements of HIV-1 binding antibody responses to support the detection of correlates of protection. Here we describe the develo…
View article: Development of a high-throughput bead based assay system to measure HIV-1 specific immune signatures in clinical samples
Development of a high-throughput bead based assay system to measure HIV-1 specific immune signatures in clinical samples Open
The monitoring and assessment of a broadly neutralizing antibody (bnAb) based HIV-1 vaccine require detailed measurements of HIV-1 binding antibody responses to support the detection of correlates of protection. Here we describe the develo…