Nikolas Furthmann
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View article: NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62
NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62 Open
NEMO is a ubiquitin-binding protein which regulates canonical NF-κB pathway activation in innate immune signaling, cell death regulation and host-pathogen interactions. Here we identified an NF-κB-independent function of NEMO in proteostas…
View article: Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease
Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease Open
Optogenetics has been harnessed to shed new mechanistic light on current and future therapeutic strategies. This has been to date achieved by the regulation of ion flow and electrical signals in neuronal cells and neural circuits that are …
View article: Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease
Optogenetic delivery of trophic signals in a genetic model of Parkinson’s disease Open
Optogenetics has been harnessed to shed new mechanistic light on current therapies and to develop future treatment strategies. This has been to date achieved by the correction of electrical signals in neuronal cells and neural circuits tha…
View article: The <i>parkin-coregulated gene</i> product PACRG promotes TNF signaling by stabilizing LUBAC
The <i>parkin-coregulated gene</i> product PACRG promotes TNF signaling by stabilizing LUBAC Open
PACRG can functionally substitute for the LUBAC adaptor subunit SHARPIN to stimulate NF-κB signaling.