Nikolaus von Knebel Doeberitz
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View article: Post-Surgical Depositions of Blood Products Are No Major Confounder for the Diagnostic and Prognostic Performance of CEST MRI in Patients with Glioma
Post-Surgical Depositions of Blood Products Are No Major Confounder for the Diagnostic and Prognostic Performance of CEST MRI in Patients with Glioma Open
Amide proton transfer (APT) and semi-solid magnetization transfer (ssMT) imaging can predict clinical outcomes in patients with glioma. However, the treatment of brain tumors is accompanied by the deposition of blood products within the tu…
View article: Semi‐solid <scp>MT</scp> and <scp>APTw CEST‐MRI</scp> predict clinical outcome of patients with glioma early after radiotherapy
Semi‐solid <span>MT</span> and <span>APTw CEST‐MRI</span> predict clinical outcome of patients with glioma early after radiotherapy Open
Purpose The purpose of this study was to compare the potential of asymmetry‐based (APTw asym ), Lorentzian‐fit‐based (PeakAreaAPT and MT const ), and relaxation‐compensated (MTR Rex APT and MTR Rex MT) CEST contrasts of the amide proton tr…
View article: Changing paradigms in oncology: Toward noncytotoxic treatments for advanced gliomas
Changing paradigms in oncology: Toward noncytotoxic treatments for advanced gliomas Open
Glial‐lineage malignancies (gliomas) recurrently mutate and/or delete the master regulators of apoptosis p53 and/or p16/CDKN2A, undermining apoptosis‐intending (cytotoxic) treatments. By contrast to disrupted p53/p16, glioma cells are live…
View article: Glioblastoma radiotherapy using Intensity modulated Radiotherapy (IMRT) or proton Radiotherapy—GRIPS Trial (Glioblastoma Radiotherapy via IMRT or Proton BeamS): a study protocol for a multicenter, prospective, open-label, randomized, two-arm, phase III study
Glioblastoma radiotherapy using Intensity modulated Radiotherapy (IMRT) or proton Radiotherapy—GRIPS Trial (Glioblastoma Radiotherapy via IMRT or Proton BeamS): a study protocol for a multicenter, prospective, open-label, randomized, two-arm, phase III study Open
Background Radiation therapy is an integral part of the multimodal primary therapy of glioblastomas. As the overall prognosis in this tumor entity remains unfavorable, current research is focused on additional drug therapies, which are oft…
View article: Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors
Cancer Immunotherapy by Targeting IDO1/TDO and Their Downstream Effectors Open
The tryptophan (TRP) to kynurenine (KYN) metabolic pathway is now firmly established as a key regulator of innate and adaptive immunity. A plethora of preclinical models suggests that this immune tolerance pathway - driven by the key and r…