Explanipedia

Interleukin-1 regulates myeloid cell trafficking and cerebral blood flow following intracerebral haemorrhage Open

Jack Barrington, Jack Rivers‐Auty, Patrick Strangward, Sabrina Tamburrano, Nikolett Lénárt , et al. · 2025

Intracerebral haemorrhage (ICH) is a devastating stroke subtype lacking effective therapies. Understanding key pathological processes related to acute brain damage will help deliver better outcomes for ICH. Herein, we provide evidence that…

Characterization of [3H]AZ12464237 as a high affinity, non-nucleotide antagonist radioligand for the P2Y12 receptor Open

E. Johanna L. Stéen, Efthalia-Natalia Tousiaki, Lee Kingston, Berend van der Wildt, Nikolett Lénárt , et al. · 2025

Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but may regulate neurorepair processes after experimental ischemic stroke Open

Eloïse Lemarchand, Alba Grayston, Raymond Wong, M. Rogers, Blake Ouvrier , et al. · 2025

Inflammation is a key contributor to stroke pathogenesis and exacerbates brain damage leading to poor outcome. Interleukin-1 (IL-1) is an important regulator of post-stroke inflammation, and blocking its actions is beneficial in pre-clinic…

Macrophages and nociceptor neurons form a sentinel unit around fenestrated capillaries to defend the synovium from circulating immune challenge Open

Tetsuo Hasegawa, Colin Y.C. Lee, Andrew Hotchen, Aaron Fleming, Rahul Singh , et al. · 2024

A wide variety of systemic pathologies, including infectious and autoimmune diseases, are accompanied by joint pain or inflammation, often mediated by circulating immune complexes (ICs). How such stimuli access joints and trigger inflammat…

Characterization of [<sup>3</sup>H]AZ12464237 as a high affinity, non-nucleotide antagonist radioligand for the P2Y12 receptor Open

E. Johanna L. Stéen, Efthalia-Natalia Tousiaki, Lee Kingston, Berend van der Wildt, Nikolett Lénárt , et al. · 2024

The purinergic receptor P2Y 12 (P2Y 12 R) is a well-recognized target for anti-thrombotic agents. This receptor is also expressed in microglia, where it plays a key role in neuroinflammation and microglia activation. To investigate P2Y 12 …

Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices Open

Péter Berki, Csaba Cserép, Zsuzsanna Környei, Balázs Pósfai, Eszter Szabadits , et al. · 2024

Selective deletion of interleukin-1 alpha in microglia does not modify acute outcome but regulates neurorepair processes after experimental ischemic stroke Open

Eloïse Lemarchand, Alba Grayston, Raymond Wong, M. Rogers, Blake Ouvrier , et al. · 2024

Inflammation is a key contributor to stroke pathogenesis and exacerbates brain damage leading to poor outcome. Interleukin-1 (IL-1) is an important regulator of post-stroke inflammation, and blocking its actions is beneficial in pre-clinic…

Mechanisms of microglial responses to injury related focal ATP events Open

Zsuzsanna Környei, Péter Berki, Csaba Cserép, Nikolett Lénárt, Balázs Pósfai , et al. · 2024

IL-1 Mediates Chronic Stress-Induced Hyperalgesia Accompanied by Microglia and Astroglia Morphological Changes in Pain-Related Brain Regions in Mice Open

Barbara Fülöp, Agnes I. Hunyady, Noémi Bencze, Viktória Kormos, Nikolett Szentes , et al. · 2023

Chronic stress causes several pain conditions including fibromyalgia. Its pathophysiological mechanisms are unknown, and the therapy is unresolved. Since the involvement of interleukin-1 (IL-1) has been described in stress and inflammatory…

The NKCC1 ion transporter modulates microglial phenotype and inflammatory response to brain injury in a cell-autonomous manner Open

Krisztina Tóth, Nikolett Lénárt, Péter Berki, Rebeka Fekete, Eszter Szabadits , et al. · 2022

The NKCC1 ion transporter contributes to the pathophysiology of common neurological disorders, but its function in microglia, the main inflammatory cells of the brain, has remained unclear to date. Therefore, we generated a novel transgeni…

Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions Open

Eszter Császár, Nikolett Lénárt, Csaba Cserép, Zsuzsanna Környei, Rebeka Fekete , et al. · 2022

Microglia, the main immunocompetent cells of the brain, regulate neuronal function, but their contribution to cerebral blood flow (CBF) regulation has remained elusive. Here, we identify microglia as important modulators of CBF both under …

Chronic T cell proliferation in brains after stroke could interfere with the efficacy of immunotherapies Open

Steffanie Heindl, Alessio Ricci, Olga Carofiglio, Qihui Zhou, Thomas Arzberger , et al. · 2021

Neuroinflammation is an emerging focus of translational stroke research. Preclinical studies have demonstrated a critical role for brain-invading lymphocytes in post-stroke pathophysiology. Reducing cerebral lymphocyte invasion by anti-CD4…

Microglia control cerebral blood flow and neurovascular coupling via P2Y12R-mediated actions Open

Eszter Császár, Nikolett Lénárt, Csaba Cserép, Zsuzsanna Környei, Rebeka Fekete , et al. · 2021

Microglia, the main immunocompetent cells of the brain regulate neuronal function in health and disease, but their contribution to cerebral blood flow (CBF) remained elusive. Here we identify microglia as important modulators of CBF both u…

Microglia alter the threshold of spreading depolarization and related potassium uptake in the mouse brain Open

Dániel Péter Varga, Ákos Menyhárt, Balázs Pósfai, Eszter Császár, Nikolett Lénárt , et al. · 2020

Selective elimination of microglia from the brain was shown to dysregulate neuronal Ca 2+ signaling and to reduce the incidence of spreading depolarization (SD) during cerebral ischemia. However, the mechanisms through which microglia inte…

Microglia monitor and protect neuronal function through specialized somatic purinergic junctions Open

Csaba Cserép, Balázs Pósfai, Nikolett Lénárt, Rebeka Fekete, Zsófia I. László , et al. · 2019

Microglia take control Changes in the activity of microglia, the primary immune cells of the central nervous system, are linked with major human diseases, including stroke, epilepsy, psychiatric disorders, and neurodegeneration. Cserép et …

Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms Open

Zsuzsanna Helyes, Valéria Tékus, Nikolett Szentes, Krisztina Pohóczky, Bálint Botz , et al. · 2019

Significance Complex regional pain syndrome (CRPS) is a poorly understood painful condition, which typically arises after distal limb trauma; 20% of patients may develop lifelong severe incessant pain with few therapeutic options. In this …

Novel therapeutic potential of angiotensin receptor 1 blockade in a rat model of diabetes-associated depression parallels altered BDNF signalling Open

Lilla Lénárt, Dóra Balogh, Nikolett Lénárt, Adrienn Bárczi, Ádám Hosszú , et al. · 2019

We identified a novel effect of losartan in the nervous system that may be implemented to alleviate symptoms of diabetes-associated depression. These findings explore a new therapeutic horizon for ARBs as possible antidepressants and sugge…

Hypoglycemia-activated Hypothalamic Microglia Impairs Glucose Counterregulatory Responses Open

Zsuzsanna Winkler, Dániel Kuti, Ágnes Polyák, Balázs Juhász, Krisztina Gulyás , et al. · 2019

Glucose is a major fuel for the central nervous system and hypoglycemia is a significant homeostatic stressor, which elicits counterregulatory reactions. Hypothalamic metabolic- and stress-related neurons initiate these actions, however re…

Microglia monitor and protect neuronal function via specialized somatic purinergic junctions Open

Csaba Cserép, Balázs Pósfai, Barbara Orsolits, Gábor Molnár, Steffanie Heindl , et al. · 2019

Microglia are the main immune cells in the brain with emerging roles in brain homeostasis and neurological diseases, while mechanisms underlying microglia-neuron communication remain elusive. Here, we identify a novel site of interaction b…

Microglia Monitor and Protect Neuronal Function Via Specialized Somatic Purinergic Junctions in an Activity-Dependent Manner Open

Csaba Cserép, Balázs Pósfai, Barbara Orsolits, Gábor Molnár, Steffanie Heindl , et al. · 2019

Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer Open

Kelly L. Singel, K.S. Grzankowski, Anzer Khan, Melissa Grimm, Anthony C. D’Auria , et al. · 2018

Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons Open

Raymond Wong, Nikolett Lénárt, L.M.R. Hill, Lauren Toms, Graham Coutts , et al. · 2018

Cerebrovascular Pathology in Hypertriglyceridemic APOB-100 Transgenic Mice Open

Zsófia Hoyk, Melinda Tóth, Nikolett Lénárt, Dóra Nagy, Brigitta Dukay , et al. · 2018

Hypertriglyceridemia is not only a serious risk factor in the development of cardiovascular diseases, but it is linked to neurodegeneration, too. Previously, we generated transgenic mice overexpressing the human APOB-100 protein, a mouse m…

Mannose-Binding Lectin Drives Platelet Inflammatory Phenotype and Vascular Damage After Cerebral Ischemia in Mice via IL (Interleukin)-1α Open

Franca Orsini, Stefano Fumagalli, Eszter Császár, Krisztina Tóth, Daiana De Blasio , et al. · 2018

Objective— Circulating complement factors are activated by tissue damage and contribute to acute brain injury. The deposition of MBL (mannose-binding lectin), one of the initiators of the lectin complement pathway, on the cerebral endothel…

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms Open

Rebeka Fekete, Csaba Cserép, Nikolett Lénárt, Krisztina Tóth, Barbara Orsolits , et al. · 2018

Abstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers Open

Andrzej Małecki, Janina Skipor-Lahuta, Michał Toborek, N. Joan Abbott, David A. Antonetti , et al. · 2017

Inflammasomes link vascular disease with neuroinflammation and brain disorders Open

Nikolett Lénárt, David Brough, Ádám Dénes · 2016

The role of inflammation in neurological disorders is increasingly recognised. Inflammatory processes are associated with the aetiology and clinical progression of migraine, psychiatric conditions, epilepsy, cerebrovascular diseases, demen…

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke Open

Gergely Szalay, Bernadett Martinecz, Nikolett Lénárt, Zsuzsanna Környei, Barbara Orsolits , et al. · 2016

Brain injury induces specific changes in the caecal microbiota of mice via altered autonomic activity and mucoprotein production Open

Ashley Houlden, Marie Goldrick, David Brough, E. Sylvester Vizi, Nikolett Lénárt , et al. · 2016

A Novel SPECT-Based Approach Reveals Early Mechanisms of Central and Peripheral Inflammation after Cerebral Ischemia Open

Krisztián Szigeti, Ildikó Horváth, Dániel Sándor Veres, Bernadett Martinecz, Nikolett Lénárt , et al. · 2015

Inflammation that develops in the brain and peripheral organs after stroke contributes profoundly to poor outcome of patients. However, mechanisms through which inflammation impacts on brain injury and overall outcome are improperly unders…

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