Nikolina Vrdoljak
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View article: PKM2 modulation regulates leukemia cell survival.
PKM2 modulation regulates leukemia cell survival. Open
Acute myeloid leukemia (AML) is characterized by an aberrant metabolic phenotype in which cells rely on aerobic glycolysis (AG) to fuel anabolic processes. Altered glycolytic genes such as pyruvate kinase (PK) are partially responsible for…
View article: Pseudolaric Acid B Targets CD147 to Selectively Kill Acute Myeloid Leukemia Cells
Pseudolaric Acid B Targets CD147 to Selectively Kill Acute Myeloid Leukemia Cells Open
Acute myeloid leukemia (AML) is an aggressive blood cancer. With low survival rates, new drug targets are needed to improve treatment regimens and patient outcomes. Pseudolaric acid B (PAB) is a plant-derived bioactive compound predicted t…
View article: Novel Mango Ginger Bioactive (2,4,6-Trihydroxy-3,5-diprenyldihydrochalcone) Inhibits Mitochondrial Metabolism in Combination with Avocatin B
Novel Mango Ginger Bioactive (2,4,6-Trihydroxy-3,5-diprenyldihydrochalcone) Inhibits Mitochondrial Metabolism in Combination with Avocatin B Open
Acute myeloid leukemia (AML) is an aggressive blood cancer with limited effective chemotherapy options and negative patient outcomes. Food-derived molecules such as avocatin B (Avo B), a fatty-acid oxidation (FAO) inhibitor, are promising …