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View article: Microfluidic Devices for Precise Measurements of Cell Directionality Reveal a Role for Glutamine during Cell Migration
Microfluidic Devices for Precise Measurements of Cell Directionality Reveal a Role for Glutamine during Cell Migration Open
Cancer cells that migrate from tumors into surrounding tissues are responsible for cancer dissemination through the body. Microfluidic devices have been instrumental in discovering unexpected features of cancer cell migration, including th…
A single-cell liver atlas of Plasmodium vivax infection Open
Malaria-causing Plasmodium vivax parasites can linger in the human liver for weeks to years and reactivate to cause recurrent blood-stage infection. Although they are an important target for malaria eradication, little is known about the m…
View article: Gene signatures and host-parasite interactions revealed by dual single-cell profiling of <i>Plasmodium vivax</i> liver infection
Gene signatures and host-parasite interactions revealed by dual single-cell profiling of <i>Plasmodium vivax</i> liver infection Open
SUMMARY Malaria-causing P. vivax parasites can linger in the human liver for weeks to years, and then reactivate to cause recurrent blood-stage infection. While an important target for malaria eradication, little is known about the molecul…
View article: dual scRNA-seq analysis of P. vivax infected hepatocytes
dual scRNA-seq analysis of P. vivax infected hepatocytes Open
Malaria-causing P. vivax parasites can linger in the human liver for weeks to months and then reactivate to cause recurrent blood-stage infection. While recognized as an important point of intervention for malaria eradication, very little …
View article: dual scRNA-seq analysis of P. vivax infected hepatocytes
dual scRNA-seq analysis of P. vivax infected hepatocytes Open
Malaria-causing Plasmodium vivax parasites can linger in the human liver for weeks to years, and then reactivate to cause recurrent blood-stage infection. While an important target for malaria eradication, little is known about the molecul…
View article: dual scRNA-seq analysis of P. vivax infected hepatocytes
dual scRNA-seq analysis of P. vivax infected hepatocytes Open
Malaria-causing Plasmodium vivax parasites can linger in the human liver for weeks to years, and then reactivate to cause recurrent blood-stage infection. While an important target for malaria eradication, little is known about the molecul…
View article: Image segmentation of liver stage malaria infection with spatial uncertainty sampling
Image segmentation of liver stage malaria infection with spatial uncertainty sampling Open
Global eradication of malaria depends on the development of drugs effective against the silent, yet obligate liver stage of the disease. The gold standard in drug development remains microscopic imaging of liver stage parasites in in vitro…
Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers Open
The malaria liver stage is an attractive target for antimalarial development, and preclinical malaria models are essential for testing such candidates. Given ethical concerns and costs associated with non‐human primate models, humanized mo…
View article: Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers
Towards a Humanized Mouse Model of Liver Stage Malaria Using Ectopic Artificial Livers Open
The malaria liver stage is an attractive target for antimalarial development, and preclinical malaria models are essential for testing such candidates. Given ethical concerns and costs associated with non‐human primate models, humanized mo…
View article: Host AMPK Is a Modulator of Plasmodium Liver Infection
Host AMPK Is a Modulator of Plasmodium Liver Infection Open
Manipulation of the master regulator of energy homeostasis AMP-activated protein kinase (AMPK) activity is a strategy used by many intracellular pathogens for successful replication. Infection by most pathogens leads to an activation of ho…
View article: Malaria Box Heatmap.
Malaria Box Heatmap. Open
Shown are selected data from the HeatMap (S1 Table) for the 400 Malaria Box compounds. Each column represents an assay (grouped by category), compounds are represented in rows. The red-green gradient represents higher to lower activity. Fa…
View article: Malaria Box compounds with activity in biological assays (malaria, helminths, <i>Wolbachia</i>, and cancer cells) and lacking toxicity at therapeutic levels.
Malaria Box compounds with activity in biological assays (malaria, helminths, <i>Wolbachia</i>, and cancer cells) and lacking toxicity at therapeutic levels. Open
Selectivity Index, SI, is toxicity level/activity level; p, probe-like; d, drug-like.
View article: Antiprotozoal Malaria Box compounds with activity in biological assays and lacking toxicity at therapeutic levels.
Antiprotozoal Malaria Box compounds with activity in biological assays and lacking toxicity at therapeutic levels. Open
Selectivity Index, SI, is toxicity level/activity level; p, probe-like; d, drug-like.
View article: Metabolomic and chemogenomic profiling.
Metabolomic and chemogenomic profiling. Open
(A) Metabolic profiling: Heat map showing metabolic fingerprints of 80 Malaria Box compounds and atovaquone control. Parasite extracts were analyzed by LC-MS, and changes in metabolite pools were calculated for drug-treated parasites as co…
View article: Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond Open
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is…
View article: Open source drug discovery with the malaria box compound collection for neglected diseases and beyond
Open source drug discovery with the malaria box compound collection for neglected diseases and beyond Open
A major cause of the paucity of new starting points for drug discovery is the lack of interaction between academia and industry. Much of the global resource in biology is present in universities, whereas the focus of medicinal chemistry is…