Niladri Basu
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View article: Enabling regulatory innovation: precaution, risk, and new approach methodologies
Enabling regulatory innovation: precaution, risk, and new approach methodologies Open
The precautionary principle, a risk management tool used to justify deliberations and actions to prevent potential risks, has guided environmental policy development and implementation, both legally and culturally, and its application may …
View article: Metals Exposures and Telomere Length as a Marker of DNA Damage Among Electronic Waste Workers and a Reference Group
Metals Exposures and Telomere Length as a Marker of DNA Damage Among Electronic Waste Workers and a Reference Group Open
Informal E-waste recycling releases complex mixtures including heavy metals that bioaccumulate in exposed populations, including e-waste workers. Emerging evidence suggests that these metals contribute to telomere attrition, leading to cel…
View article: Transcriptomic points of departure for 6PPD-Quinone derived from human Caco-2 and HepG2 cells
Transcriptomic points of departure for 6PPD-Quinone derived from human Caco-2 and HepG2 cells Open
N-(1,3-Dimethyl butyl)-N'-phenyl-phenylenediamine-quinone (6ppd-quinone) is of emerging concern due to its widespread presence and toxicity to aquatic species. The chemical has been detected in human biofluids though little is known about …
View article: Integrative Modeling of Urinary Metabolomics and Metal Exposure Reveals Systemic Impacts of Electronic Waste in Exposed Populations
Integrative Modeling of Urinary Metabolomics and Metal Exposure Reveals Systemic Impacts of Electronic Waste in Exposed Populations Open
Background: Informal electronic waste (e-waste) recycling practices release a complex mixture of pollutants, particularly heavy metals, into the environment. Chronic exposure to these contaminants has been linked to a range of health risks…
View article: Comparison of in vitro transcriptomic points of departure with fish acute and chronic toxicity values: a case study of rainbow trout cells exposed to pesticides
Comparison of in vitro transcriptomic points of departure with fish acute and chronic toxicity values: a case study of rainbow trout cells exposed to pesticides Open
There is growing interest in transcriptomic points of departure (tPOD) values from in vitro experiments as an alternative to animal test method. The study objective was to calculate tPODs in rainbow trout gill cells (RTgill-W1 following Or…
View article: On Fair Ordering and Differential Privacy
On Fair Ordering and Differential Privacy Open
In blockchain systems, fair transaction ordering is crucial for a trusted and regulation-compliant economic ecosystem. Unlike traditional State Machine Replication (SMR) systems, which focus solely on liveness and safety, blockchain system…
View article: Interaction of mercury exposure and DNA methylation with sustained attention in children in a novel analysis of epigenetic susceptibility
Interaction of mercury exposure and DNA methylation with sustained attention in children in a novel analysis of epigenetic susceptibility Open
The etiology of attention-deficit/hyperactivity disorder (ADHD) remains poorly understood, despite it being one of the most common neurodevelopmental disorders worldwide. Past research suggests methylmercury exposure and DNA methylation (D…
View article: TPD-seq: A high throughput RNA-seq method to derive transcriptomic points of departure from cell lines
TPD-seq: A high throughput RNA-seq method to derive transcriptomic points of departure from cell lines Open
There is growing scientific and regulatory interest in transcriptomic points of departure (tPOD) values from high-throughput in vitro experiments. To further help democratize tPOD research, here we outline 'TPD-seq' which links microplate-…
View article: Comprehensive Blood Metabolome and Exposome Analysis, Annotation, and Interpretation in E-Waste Workers
Comprehensive Blood Metabolome and Exposome Analysis, Annotation, and Interpretation in E-Waste Workers Open
Background: Electronic and electrical waste (e-waste) production has emerged to be of global environmental public health concern. E-waste workers, who are frequently exposed to hazardous chemicals through occupational activities, face cons…
View article: Alternatives assessment of polyvinylidene fluoride-compatible solvents for N-methyl pyrrolidone substitution in lithium-ion battery cathodes
Alternatives assessment of polyvinylidene fluoride-compatible solvents for N-methyl pyrrolidone substitution in lithium-ion battery cathodes Open
Lithium-ion batteries (LIBs) are central to electrification yet, to increase the efficiency and scalability of electric systems, energy storage technologies must integrate sustainability concepts into their design. Notably, the incumbent L…
View article: The DIKW of transcriptomics in ecotoxicology: extracting information, knowledge, and wisdom from big data
The DIKW of transcriptomics in ecotoxicology: extracting information, knowledge, and wisdom from big data Open
In the early 2000s, transcriptomics was emerging as a new science with seemingly limitless potential. Originally coined by Charles Auffray (McGettigan, 2013), the term transcriptomics refers to the measurement of levels of all expressed ge…
View article: Inconsistent transcriptomic responses to hexabromocyclododecane in Japanese quail: a comparative analysis of results from four different study designs
Inconsistent transcriptomic responses to hexabromocyclododecane in Japanese quail: a comparative analysis of results from four different study designs Open
Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degre…
View article: Screening 800 putative endocrine disrupting chemicals in a representative mammal, bird, and fish using a neurochemical cell-free testing platform
Screening 800 putative endocrine disrupting chemicals in a representative mammal, bird, and fish using a neurochemical cell-free testing platform Open
There is global demand for novel ecotoxicity testing tools that are based on alternative to animal models, have high throughput potential, and may be applicable to a wide diversity of taxa. Here we scaled up a microplate-based cell-free ne…
View article: MetaboAnalystR 4.0: a unified LC-MS workflow for global metabolomics
MetaboAnalystR 4.0: a unified LC-MS workflow for global metabolomics Open
The wide applications of liquid chromatography - mass spectrometry (LC-MS) in untargeted metabolomics demand an easy-to-use, comprehensive computational workflow to support efficient and reproducible data analysis. However, current tools w…
View article: Global mercury concentrations in biota: their use as a basis for a global biomonitoring framework
Global mercury concentrations in biota: their use as a basis for a global biomonitoring framework Open
An important provision of the Minamata Convention on Mercury is to monitor and evaluate the effectiveness of the adopted measures and its implementation. Here, we describe for the first time currently available biotic mercury (Hg) data on …
View article: Exploring practices, challenges, and priorities for human health and ecological risk assessments in Indigenous communities in Canada
Exploring practices, challenges, and priorities for human health and ecological risk assessments in Indigenous communities in Canada Open
Indigenous peoples in Canada are disproportionately exposed to environmental contaminants and may face elevated health risks related to their unique cultural, spiritual, and economic relationships with the land, including the use of tradit…
View article: Cytotoxic and molecular effects of soil extracts from the Agbogbloshie electronic-waste site on fish and human cell lines
Cytotoxic and molecular effects of soil extracts from the Agbogbloshie electronic-waste site on fish and human cell lines Open
Effect-based methods (EBM) are of growing interest in environmental monitoring programs.
View article: Cytotoxicity of 19 pesticides in rainbow trout gill, liver, and intestinal cell lines
Cytotoxicity of 19 pesticides in rainbow trout gill, liver, and intestinal cell lines Open
The rainbow trout gill cell line (RTgill-W1), via test guideline 249 of the Organisation for Economic Co-operation and Development, has been established as a promising New Approach Methodology, although to advance confidence in the method …
View article: Comparing transcriptomic responses to chemicals across six species using the EcoToxChip RNASeq database
Comparing transcriptomic responses to chemicals across six species using the EcoToxChip RNASeq database Open
The EcoToxChip project includes RNA-sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double-crested cormorant, rainbow trout, northern leopard frog) species at multiple …
View article: Hepatic Transcriptomic Responses to Ethinylestradiol in Embryonic Japanese Quail and Double-Crested Cormorant
Hepatic Transcriptomic Responses to Ethinylestradiol in Embryonic Japanese Quail and Double-Crested Cormorant Open
Understanding species differences in sensitivity to toxicants is a critical issue in ecotoxicology. We recently established that double-crested cormorant (DCCO) embryos are more sensitive than Japanese quail (JQ) to the developmental effec…
View article: Contaminated sites and Indigenous peoples in Canada and the United States: A scoping review
Contaminated sites and Indigenous peoples in Canada and the United States: A scoping review Open
Indigenous communities are disproportionately exposed to contaminated sites, and this poses unique challenges as many Indigenous peoples consider land as an integral part of their culture and economy. This scoping review aimed to identify …
View article: Iron- and protein rich diets may boost hemoglobin levels among informal electronic waste recyclers exposed to metals at Agbogbloshie, Ghana
Iron- and protein rich diets may boost hemoglobin levels among informal electronic waste recyclers exposed to metals at Agbogbloshie, Ghana Open
While human exposure to metals may play a role in the pathogenesis of anemia, consumption of balanced diets may boost blood hemoglobin (Hb) levels in humans. Although informal electronic waste (e-waste) recycling processes have recently dr…
View article: Towards establishing a 24-hour, microplate-based, transcriptomics assay for rainbow trout embryos
Towards establishing a 24-hour, microplate-based, transcriptomics assay for rainbow trout embryos Open
There is interest in the development of early-life stage (ELS) tests with fish embryo models that are high-throughput and can generate transcriptomics point of departure (tPOD) values. The objective of this study was to establish a method …
View article: Mercury accumulation, biomagnification, and relationships to δ13C, δ15N and δ34S of fishes and marine mammals in a coastal Arctic marine food web
Mercury accumulation, biomagnification, and relationships to δ13C, δ15N and δ34S of fishes and marine mammals in a coastal Arctic marine food web Open
Combining mercury and stable isotope data sets of consumers facilitates the quantification of whether contaminant variation in predators is due to diet, habitat use and/or environmental factors. We investigated inter-species variation in t…
View article: Factors Influencing Mercury Exposure in Arctic-Breeding Shorebirds
Factors Influencing Mercury Exposure in Arctic-Breeding Shorebirds Open
Mercury (Hg) pollution remains a concern to Arctic ecosystems. The objective of this study was to identify factors influencing Hg concentrations in Arctic-breeding shorebirds and highlight regions and species at greatest risk of Hg exposur…
View article: Association between heavy metal uptake and growth and reproduction in the anecic earthworm, Alma nilotica
Association between heavy metal uptake and growth and reproduction in the anecic earthworm, Alma nilotica Open
Elevated heavy metal concentrations in soils is a cause for concern as they are hazardous to soil organisms including earthworms which are considered as ecosystem engineers. Current ecotoxicity tests predominantly use temperate earthworm s…