Nilay Nandi
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View article: STING controls energy stress-induced autophagy and energy metabolism via STX17
STING controls energy stress-induced autophagy and energy metabolism via STX17 Open
The stimulator of interferon genes (STING) plays a critical role in innate immunity. Emerging evidence suggests that STING is important for DNA or cGAMP-induced non-canonical autophagy, which is independent of a large part of canonical aut…
View article: A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress
A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress Open
Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that in Drosophila starvation-independent quality control autophagy is regulated b…
View article: In situ Dephosphorylation Assay with Recombinant Nil Phosphatase
In situ Dephosphorylation Assay with Recombinant Nil Phosphatase Open
The activity of numerous autophagy-related proteins depends on their phosphorylation status, which places importance on understanding the responsible kinases and phosphatases. Great progress has been made in identifying kinases regulating …
View article: A phospho-switch at Acinus-Serine <sup>437</sup> controls autophagic responses to Cadmium exposure and neurodegenerative stress
A phospho-switch at Acinus-Serine <sup>437</sup> controls autophagic responses to Cadmium exposure and neurodegenerative stress Open
Summary Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that in Drosophila starvation-independent quality control autophagy is reg…
View article: Cdk5-mediated Acn/Acinus phosphorylation regulates basal autophagy independently of metabolic stress
Cdk5-mediated Acn/Acinus phosphorylation regulates basal autophagy independently of metabolic stress Open
In neurons, autophagy counteracts consequences of aging. It is therefore of interest how basal rates of macroautophagy/autophagy can be controlled independently of metabolic stress. We recently investigated the regulation of basal, starvat…
View article: Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437
Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437 Open
Cdk5 is a post-mitotic kinase with complex roles in maintaining neuronal health. The various mechanisms by which Cdk5 inhibits and promotes neurodegeneration are still poorly understood. Here, we show that in Drosophila melanogaster Cdk5 r…
View article: Author response: Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437
Author response: Stress-induced Cdk5 activity enhances cytoprotective basal autophagy in Drosophila melanogaster by phosphorylating acinus at serine437 Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Cdk5 is a post-mitotic kinase with complex role…