Nili Stein
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View article: Increased risk of psoriatic arthritis in patients with familial Mediterranean fever: a population-based cohort study
Increased risk of psoriatic arthritis in patients with familial Mediterranean fever: a population-based cohort study Open
Objective Familial Mediterranean fever (FMF) is an autosomal recessive autoinflammatory disease, associated with various inflammatory conditions. IL-1 is involved in the underlying pathogenesis of both FMF and psoriatic arthritis (PsA). Ho…
Glucagon-like peptide 1 receptor agonists switching patterns in type two diabetes: A retrospective real-world study Open
BACKGROUND Glucagon-like peptide-1 receptor agonists (GLP-1RAs) play a key role in managing type 2 diabetes mellitus (T2DM). Transitioning between different GLP-1RA has been proposed as a treatment strategy. AIM To investigate switching pa…
Clostridioides difficile infection among patients with type 2 diabetes mellitus Open
Clostridioides difficile infection (CDI) poses a significant healthcare burden. Patients with diabetes mellitus (DM) are at increased risk of poor outcomes. This study aims to compare CDI outcomes, including mortality, in patients with and…
Diabetes Control and Clinical Outcomes in Chronic Obstructive Pulmonary Disease (COPD) Exacerbation Open
Background: Type 2 diabetes mellitus (T2DM) is common among patients with chronic obstructive pulmonary disease (COPD). We examined the association between glycemic control and clinical outcomes in patients with COPD exacerbation and T2DM.…
Efficacy and safety of direct oral anticoagulants in patients with venous thrombosis and inherited thrombophilia Open
Introduction: Inherited thrombophilia screening is widely performed in patients with venous thromboembolism (VTE). Although recent studies suggest that direct oral anticoagulants (DOACs) may provide comparable efficacy and safety to Vitami…
View article: Biologic switching in psoriatic arthritis: Insights from real-world data and key risk factors
Biologic switching in psoriatic arthritis: Insights from real-world data and key risk factors Open
Cross class biologic switching is common in PsA management (48 %) and influenced by patient demographics and comorbidities. Switching patterns were consistent across time periods despite expanding therapeutic options.
Diabetes Comorbidity and Quality of Life in Patients with Cancer: A Prospective Study in an Integrative Oncology Setting Open
Background: Research on quality of life (QoL)-related concerns among patients with both diabetes mellitus (DM) and cancer is limited. This study compared the QoL-related concerns and characteristics among chemotherapy-treated patients with…
Celiac in the twenty-first century—the change in BMI of children at diagnosis over the last two decades Open
This study examined the prevalence of different BMI categories among newly diagnosed pediatric celiac disease (CD) patients in Israel from 2002 to 2018. A retrospective cross-sectional study using the database of Clalit Health Services in …
Sars‐Cov‐2 infection and dementia risk: a nationwide, nested case‐control study Open
Background Cognitive impairment following Sars‐Cov‐2 infection is common. We aimed to explore whether covid‐19 is associated with a higher risk of dementia in a nationwide sample of middle‐age and older Israeli adults. Method This nested c…
Efficacy, adherence and persistence of various glucagon‐like peptide‐1 agonists: nationwide real‐life data Open
Aim The management of type 2 diabetes mellitus has advanced in the last two decades since the introduction of glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs). However, multiple factors may interfere with achieving better glycaemic con…
Phosphodiesterase-5 Inhibitors and Dementia Risk: A Real-World Study Open
Introduction: Biological and scarce epidemiological evidence suggested that phosphodiesterase-5 inhibitors (PDE5i) might reduce dementia risk. We aimed to examine the association between PDE5i and dementia using real-world data. Methods: T…
Medications and Acute Hemolysis in G6PD‐Deficient Patients – A Real‐World Study Open
Many drug labels contain precautions of use in G6PD‐deficient patients due to hemolytic concerns, but much of this is based on scarce clinical, epidemiological, or structural data. In this real‐world study, we aimed to examine if the admin…
Diagnostic delay and access to care in bronchiectasis: data from the EMBARC/ELF patient survey Open
The EMBARC/ELF patient survey shows a need for increasing the availability of and access to expert bronchiectasis care and services https://bit.ly/3QTWY0E
Epidemiological trends in psoriatic arthritis: a comprehensive population-based study Open
Background Psoriatic arthritis (PsA) is a chronic, potentially debilitating inflammatory arthritis often associated with psoriasis. Understanding the epidemiology of PsA across diverse populations can provide valuable insights into its glo…
Factors associated with keratoconus in Israel—A cross‐sectional population‐based study Open
Purpose To identify potential factors associated with keratoconus. Methods This cross‐sectional study included data from Israel's largest healthcare provider for the years 2005–2020. Keratoconus patients and age‐matched controls were ident…
Celiac in the 21st century – the change in BMI of children at diagnosis over the last two decades Open
Purpose: This study examined the prevalence of different BMI categories among newly diagnosed pediatric Celiac Disease (CD) patients in Israel from 2002 to 2018. Methods: A retrospective cross-sectional study using the database of Clalit H…
View article: COVID-19 Vaccine Effectiveness among Patients with Psoriatic Disease: A Population-Based Study
COVID-19 Vaccine Effectiveness among Patients with Psoriatic Disease: A Population-Based Study Open
Limited information is available on the effectiveness of COVID-19 vaccination in patients with psoriasis and psoriatic arthritis (psoriatic disease (PsD)). The objective of our research was to assess the effectiveness of mRNA COVID-19 vacc…
Clinical outcomes of clostridioides difficile infection in the very elderly Open
Background Clostridioides difficile infection (CDI) causes considerable morbidity, mortality, and economic cost. Advanced age, prolonged stay in healthcare facility, and exposure to antibiotics are leading risk factors for CDI. Data on CDI…
View article: Identifying Factors Associated With Disparities in Access to Integrative Oncology Program
Identifying Factors Associated With Disparities in Access to Integrative Oncology Program Open
Patients' ethno-national origin and immigration status (primary language, Arabic and Russian), male gender and older age were associated with lower rates of referral to and attendance of the IP consultation, with reduced adherence to weekl…
View article: Risk factors for recurrent acute mastoiditis in pediatric patients: a registry-based cohort study
Risk factors for recurrent acute mastoiditis in pediatric patients: a registry-based cohort study Open
Objective To describe characteristics of pediatric patients with recurrent acute mastoiditis, and to identify risk factors for this condition. Study design A retrospective cohort study. Setting Data based on electronic medical records of t…
View article: Rhinitis medicamentosa – comparing two treatment strategies: a retrospective analysis
Rhinitis medicamentosa – comparing two treatment strategies: a retrospective analysis Open
Objective Rhinitis medicamentosa poses a therapeutic challenge for both patients and physicians. Treatment strategies vary, starting with avoidance of decongestants, followed by medications or surgical intervention. This study aimed to com…
View article: The Risk of Herpes Zoster Events in Patients with Spondyloarthritis and the Effect of BNT162b2 mRNA COVID-19 Vaccine
The Risk of Herpes Zoster Events in Patients with Spondyloarthritis and the Effect of BNT162b2 mRNA COVID-19 Vaccine Open
The data on the risk of herpes zoster (HZ) in spondyloarthropathy (SpA) patients are sparse, especially regarding its association with the novel mRNA COVID-19 vaccines and immunosuppressants. We aimed to evaluate whether SpA diagnosis and/…
View article: Treatment Persistence of Apremilast Among Patients with Psoriatic Arthritis
Treatment Persistence of Apremilast Among Patients with Psoriatic Arthritis Open
In this large observational retrospective cohort of patients treated with apremilast, a relatively low drug persistence was observed with 6-month and 1-year survival rates of 50.3% and 31.3%, respectively. Treatment discontinuation was mai…
Risk of SARS-CoV-2 infection and disease severity among people with bronchiectasis: analysis of three population registries Open
Introduction: It is unknown whether people with bronchiectasis have an increased risk for severe disease if infected with SARS-CoV-2. We aimed to determine- 1. the risk of SARS-CoV2 infection among people with bronchiectasis, and 2. the ri…
P-050 Using a second sample of ejaculate for IVF treatment Open
Study question Is it beneficial to use the second sample of ejaculate collected within 2 hours from the previous sample to fertilize the oocytes in IVF treatments? Summary answer A significantly higher clinical pregnancy rate was achieved …
Development of Autoantibodies Following BNT162b2 mRNA COVID-19 Vaccination and Their Association with Disease Flares in Adult Patients with Autoimmune Inflammatory Rheumatic Diseases (AIIRD) and the General Population: Results of 1-Year Prospective Follow-Up Study Open
Development of autoantibodies following BNT162b2 mRNA COVID-19 vaccination and their association with disease flares in adult patients with autoimmune inflammatory rheumatic diseases (AIIRD) and the general population: results of 1-year pr…