Nilima Biswas
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View article: Adenosine diphosphate stimulates VEGF-independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy
Adenosine diphosphate stimulates VEGF-independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy Open
We hypothesized that a strategy employing tissue-specific endothelial cells (EC) might facilitate the identification of tissue- or organ-specific vascular functions of ubiquitous metabolites. An unbiased approach was employed to identify w…
View article: Catestatin improves heart metabolic flexibility by promoting mitochondrial structure and function
Catestatin improves heart metabolic flexibility by promoting mitochondrial structure and function Open
Hypertension, a major cause of cardiomyopathy, is one of the most critical risk factors for heart failure and mortality worldwide. Loss of metabolic flexibility of cardiomyocytes is one of the major causes of heart failure. Although Catest…
View article: Surfactant micellar induced aggregation control of an anionic fluorescent dye in Langmuir-Blodgett film
Surfactant micellar induced aggregation control of an anionic fluorescent dye in Langmuir-Blodgett film Open
This work reports the formation of stable Langmuir monolayer of an anionic water soluble fluorescent dye 5(6)-carboxyfluorescein (abbreviated as CFS) by electrostatic interaction with a cationic monolayer. Formation of non-fluorescent H-di…
View article: Correction to: Deriving psychiatric symptom-based biomarkers from multivariate relationships between psychophysiological and biochemical measures
Correction to: Deriving psychiatric symptom-based biomarkers from multivariate relationships between psychophysiological and biochemical measures Open
View article: Deriving psychiatric symptom-based biomarkers from multivariate relationships between psychophysiological and biochemical measures
Deriving psychiatric symptom-based biomarkers from multivariate relationships between psychophysiological and biochemical measures Open
View article: LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy
LIF, a mitogen for choroidal endothelial cells, protects the choriocapillaris: implications for prevention of geographic atrophy Open
View article: Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders
Heparin-binding VEGFR1 variants as long-acting VEGF inhibitors for treatment of intraocular neovascular disorders Open
Significance Vascular endothelial growth factor (VEGF) inhibitors have transformed the treatment of intraocular vascular disorders. However, the burden of frequent intravitreal injections reduces patient compliance such that the impact in …
View article: Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure
Genes and environment: novel, functional polymorphism in the human cathepsin L (CTSL1) promoter disrupts a xenobiotic response element (XRE) to alter transcription and blood pressure Open
Cathepsin L (CTSL1) catalyzes the formation of peptides that influence blood pressure (BP). Naturally occurring genetic variation or targeted ablation of the Ctsl1 locus in mice yield cardiovascular pathology. Here, we searched for genetic…
View article: Author Correction: A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function
Author Correction: A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function Open
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
View article: Chromogranin A pathway: from pathogenic molecule to renal disease
Chromogranin A pathway: from pathogenic molecule to renal disease Open
Background: Chromogranin A (CHGA) is an index granin protein critical for biogenesis and exocytotic release of catecholamine storage granules. It is elevated in plasma of patients with sympathetic over-activity and kidney dysfunction. Seve…
View article: A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function
A new common functional coding variant at the DDC gene change renal enzyme activity and modify renal dopamine function Open
View article: Identification of novel loci affecting circulating chromogranins and related peptides
Identification of novel loci affecting circulating chromogranins and related peptides Open
Chromogranins are pro-hormone secretory proteins released from neuroendocrine cells, with effects on control of blood pressure. We conducted a genome-wide association study for plasma catestatin, the catecholamine release inhibitory peptid…
View article: Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system
Polymorphisms at the F12 and KLKB1 loci have significant trait association with activation of the renin-angiotensin system Open
The functional variants of KLKB1 (rs3733402) and F12 (rs1801020) disrupted the cascade of enzymatic events, resulting in diminished formation of active renin. Using genetic, cellular and molecular approaches we found that conversion of zym…
View article: Role of the gluconeogenic/glycogenolytic enzyme G6Pase: Response to PST, GRP78, and inhibition of GRP78's ATPase enzymatic activity.
Role of the gluconeogenic/glycogenolytic enzyme G6Pase: Response to PST, GRP78, and inhibition of GRP78's ATPase enzymatic activity. Open
(A) G6Pase expression, PST, and GRP78. Human HepG2 hepatocytes were transfected with G6P-ase→luciferase, along with pCMV-GRP78 or an empty vector (pCMV promoter without insert). 5 hrs after transfection, cells were treated wi…