Explanipedia

Exploring the uncharted: Novel potential brugian filariasis vectors unveiled in Sri Lanka Open

Sachini U. Nimlarathna, Hiruni Harischandra, T.G.A.N. Chandrasena, Michael J. Kimber, Nilanthi de Silva , et al. · 2025

Background Sri Lanka is experiencing a re-emergence of brugian filariasis post-Lymphatic Filariasis elimination. A comprehensive understanding of the mosquito species that can facilitate the development of the brugian parasite is essential…

An Overview of Dengue Knowledge, Attitudes, and Practices (KAPs) Among the General Public in Sri Lanka: A Review and Meta-Analysis of Questionnaire-Based Surveys from 2000–2023 Open

T.G.A.N. Chandrasena, Dileepa Senajith Ediriweera, Deshaka Jayakody, Nayana Gunathilaka, R. Premaratna · 2025

The objective was to conduct a review and meta-analysis of questionnaire-based surveys of dengue knowledge, attitudes, perceptions, and practices (KAP)s among the general public in Sri Lanka as no prior island-wide survey existed. The elec…

Clinico-epidemiological and immunological characteristics of rickettsioses in a Sri Lankan patient cohort 2018–2023 Open

Nayana Gunathilaka, T.G.A.N. Chandrasena, Hemantha Sudusinghe, Vidusha Nethsara Mudalpath, Deshaka Jayakody , et al. · 2025

Background Rickettsioses, caused by intracellular bacteria of the genera Rickettsia and Orientia , are transmitted to humans through arthropod vectors such as ticks, fleas, and mites. Over the past two decades, this disease has been recogn…

Abundance and taxonomic characterization of chigger mites (Acari: Trombiculidae and Walchiidae) associated with rodents in selected scrub typhus-prone areas in Southern and Western provinces of Sri Lanka Open

A. S. U. Liyanage, Nayana Gunathilaka, R. P. P. K. Premarathne, T.G.A.N. Chandrasena, Fernando de Castro Jacinavicius , et al. · 2024

Larval trombiculid mites (chiggers) are the vectors and reservoirs of the potentially lethal infectious disease, scrub typhus (ST) caused by Orientia tsutsugamushi. Small rodents are natural hosts of parasitic larval stage of the chigger m…

Exploring the uncharted: Novel potential filariasis vectors unveiled in Sri Lanka Open

Sachini U Nimalrathna, Chathuri Amarasiri, Kaveesha Aluthge, Chandana Harendra Mallawarachchi, T.G.A.N. Chandrasena , et al. · 2024

Brugian filariasis (BF) has reemerged in Sri Lanka recently. Studies suggest the emergence of a variant brugian parasite. Knowledge on transmission dynamics is important in restraining the spread of infection. This study investigated the p…

The impact of the National Programme to Eliminate Lymphatic Filariasis on filariasis morbidity in Sri Lanka: Comparison of current status with retrospective data following the elimination of lymphatic filariasis as a public health problem Open

Indeewarie E Gunaratna, T.G.A.N. Chandrasena, Murali Vallipuranathan, R. Premaratna, Dileepa Senajith Ediriweera , et al. · 2024

Introduction Sri Lanka implemented the National Programme for Elimination of Lymphatic Filariasis (NPELF) in its endemic regions in 2002. Five annual rounds of mass drug administration using the two-drug combination diethylcarbamazine (DEC…

Diversity of Wolbachia infections in Sri Lankan mosquitoes with a new record of Wolbachia Supergroup B infecting Aedes aegypti vector populations Open

N.D.A.D. Wijegunawardana, Y.I.N.S. Gunawardene, W. Abeyewickreme, T.G.A.N. Chandrasena, Parinda Thayanukul , et al. · 2024

Wolbachia bacteria are common endosymbionts of insects and have recently been applied for controlling arboviral vectors, especially Aedes aegypti mosquito populations. However, several medically important mosquito species in Sri Lanka were…

Lymphatic filariases and soil-transmitted helminthiases in Sri Lanka: the challenge of eliminating residual pockets of transmission Open

T.G.A.N. Chandrasena, I. E. Gunaratna, Dileepa Senajith Ediriweera, N. R. de Silva · 2023

Sri Lanka has successfully met the challenge of controlling both lymphatic filariasis (LF) and soil-transmitted helminthiases (STH) as public health problems. The primary public health strategy for combatting both conditions has been preve…

Wb_data from Lymphatic filariases and soil-transmitted helminthiases in Sri Lanka: the challenge of eliminating residual pockets of transmission Open

T.G.A.N. Chandrasena, I. E. Gunaratna, Dileepa Senajith Ediriweera, N. R. De Silva · 2023

Sri Lanka has successfully met the challenge of controlling both lymphatic filariasis (LF) and soil-transmitted helminthiases (STH) as public health problems. The primary public health strategy for combatting both conditions has been by pr…

Entomology data from Lymphatic filariases and soil-transmitted helminthiases in Sri Lanka: the challenge of eliminating residual pockets of transmission Open

T.G.A.N. Chandrasena, I. E. Gunaratna, Dileepa Senajith Ediriweera, N. R. De Silva · 2023

Sri Lanka has successfully met the challenge of controlling both lymphatic filariasis (LF) and soil-transmitted helminthiases (STH) as public health problems. The primary public health strategy for combatting both conditions has been preve…

Public knowledge, practices and perceptions on typhus fevers in Southern Sri Lanka Open

A. S. U. Liyanage, T.G.A.N. Chandrasena, Nayana Gunathilaka, Ruwan Sanjeewa, R. Premaratna · 2022

Objective: To assess public knowledge, practices and perceptions on typhus fevers in Sri Lanka. Methods: A descriptive study was done in four selected typhus- prone areas in Southern Sri Lanka. A mixed-method was employed using face-to-fac…

A Preliminary Survey for Filarial Parasites among Dogs and Cats in Mahawewa, Puttalam and their Vector Identification Open

Sachini U Nimalrathna, C. Mallwarachchi, T.G.A.N. Chandrasena, N. De Silva, Michael J. Kimber , et al. · 2022

Lymphatic filariasis in the Southeast Asian region; status and control options Open

T.G.A.N. Chandrasena, R. Premaratna, Chandana Harendra Mallawarachchi, Dinesh G.A.M. Gunaratna, Nilanthi R. de · 2020

The Global Program to Eliminate Lymphatic Filariasis (GPELF) was launched in year 2000 by the World Health Organization (WHO) with the goal set for elimination by 2020. Over half the global disease burden lies in the Southeast Asian region…

Potential zoonotic hosts and vectors of scrub typhus in Sri Lanka: A preliminary report Open

M.L.S. Ashani, T.G.A.N. Chandrasena, Nayana Gunathilaka, R. Premaratna · 2020

Molecular characterization of a re-emergent Brugia malayi parasite in Sri Lanka, suggestive of a novel strain with close nucleotide homology to Brugia pahangi Open

Chandana Harendra Mallawarachchi, T.G.A.N. Chandrasena, Ranjan Premarathna, S.M.N.S.M. Maleesha Mallawarachchi, Nilmini Y. I. S. Gunawardane , et al. · 2020

Background Brugian filariasis has re-emerged in Sri Lanka after four decades of quiescence. As microscopy alone was insufficient for ascertaining the species identity of the re-emerged sub-periodic Brugia spp . parasite, molecular speciati…

Descriptive Investigation of Strongyloidiasis Infection and Characterization of <i>Strongyloides stercoralis</i> Using Morphological and Molecular-Based Methods Open

Nayana Gunathilaka, T.G.A.N. Chandrasena, Tharaka Wijerathna, Yoshito Fuji, Deepa Gunasekara , et al. · 2020

Strongyloidiasis is caused by the nematode Strongyloides stercoralis which has the unique ability to reproduce and complete its entire life cycle within the human host through its autoinfection cycle. Diagnosis of this infection is importa…

Molecular Characterization of a Re-Emergent Brugia Malayi Parasite in Sri Lanka, Suggestive of a Novel Strain With Close Nucleotide Homology to Brugia Pahangi Open

Chandana Harendra Mallawarachchi, T.G.A.N. Chandrasena, Ranjan Premarathna, S.M.N.S.M. Maleesha Mallawarachchi, Nilmini Y. I. S. Gunawardane , et al. · 2020

Background Brugian filariasis has re-emerged in Sri Lanka after four decades of quiescence. As microscopy alone was insufficient for ascertaining the species identity of the re-emerged sub-periodic Brugia spp . parasite, molecular speciati…

Epidemiology of cutaneous leishmaniasis in a newly emerging focus in Gampaha district, Western province of Sri Lanka Open

Chandana Harendra Mallawarachchi, T.G.A.N. Chandrasena, Tharaka Wijerathna, Rasika Dalpadado, Maleesha S.M.N.S. Mallawarachchi , et al. · 2020

Background Cutaneous leishmaniasis (CL) appears to be spreading to previously non-endemic regions of Sri Lanka. The aim of this study was to describe a newly emerging focus of CL in the district of Gampaha, in Western Sri Lanka. Methods A …

Epidemiology of cutaneous leishmaniasis in a newly emerging focus in Gampaha district, Western province of Sri Lanka Open

Chandana Harendra Mallawarachchi, T.G.A.N. Chandrasena, Tharaka Wijerathna, Rasika Dalpadado, Maleesha S.M.N.S. Mallawarachchi , et al. · 2020

Background: Cutaneous leishmaniasis (CL) appears to be spreading to previously non-endemic regions of Sri Lanka. The aim of this study was to describe a newly emerging focus of CL in the district of Gampaha, in Western Sri Lanka. Methods: …

The Diversity of Human Dirofilariasis in Western Sri Lanka Open

T.G.A.N. Chandrasena, R. Premaratna, Chammika Mallawaarachchi, N.K. Gunawardena, Nayana Gunathilaka , et al. · 2019

Background. Human dirofilariasis is an emerging zoonosis in many countries. Dirofilariasis caused by Dirofilaria repens may present with diverse clinical manifestations in humans due to aberrant localization of worm lesions causing diagnos…

Prevalence of Ectoparasitic Infections and Other Dermatological Infections and Their Associated Factors among School Children in Gampaha District, Sri Lanka Open

Nayana Gunathilaka, T.G.A.N. Chandrasena, Lahiru Udayanga · 2019

Skin disorders are one of the commonest conditions among school children in developing countries. There are only a few published studies available from Sri Lanka on the prevalence of skin disorders. A community-based cross-sectional study …

Evaluation of the Effects of<i> Aedes</i> Vector Indices and Climatic Factors on Dengue Incidence in Gampaha District, Sri Lanka Open

N.D.A.D. Wijegunawardana, Y.I.N.S. Gunawardene, T.G.A.N. Chandrasena, R. S. Dassanayake, Lahiru Udayanga , et al. · 2019

Constant monitoring of Aedes vector indices such as Aedes mosquito abundance and ovitrap data is important for the control of dengue epidemics. Therefore, the current study attempted to evaluate the effect of larval and climatic factors on…

A preliminary survey of filarial parasites in dogs and cats in Sri Lanka Open

Chandana Harendra Mallawarachchi, T.G.A.N. Chandrasena, Susiji Wickramasinghe, R. Premaratna, Nilmini Y. I. S. Gunawardane , et al. · 2018

Human brugian filariasis has re-emerged in Sri Lanka after a quiescent period of four decades. This study investigated the prevalence of canine and feline filarial parasites in three localities with human sub-periodic brugian filariasis, i…

Morbidity management and disability prevention for lymphatic filariasis in Sri Lanka: Current status and future prospects Open

T.G.A.N. Chandrasena, R. Premaratna, I. E. Gunaratna, Nilanthi R. de Silva · 2018

The recommended basic package of MMDP was functional in most of the LF-endemic region. The highlighted weaknesses and challenges, unless addressed, may threaten program sustainability. The identified opportunities for improvement of the pr…

Human infection with sub-periodic Brugia spp. in Gampaha District, Sri Lanka: a threat to filariasis elimination status? Open

Chandana Harendra Mallawarachchi, T.G.A.N. Chandrasena, R. Premaratna, S. M. N. S. M. Mallawarachchi, Nilanthi R. de Silva · 2018

DETECTION OF A CASE OF BRUGIAN FILARIASIS FROM ANURADHAPURA, A NON-ENDEMIC DISTRICT OF SRI LANKA Open

Chandana Harendra Mallawarachchi, S. M. N. S. M. Mallawarachchi, T.G.A.N. Chandrasena, D. A. Mendis · 2018

Poster presentation Abstract (PP093), 131st Annual Scientific Sessions, Sri Lanka Medical Association, 26th-29th July 2018 Colombo, Sri Lanka

Genotypic characterization of Orientia tsutsugamushi from patients in two geographical locations in Sri Lanka Open

R. Premaratna, Lucas S. Blanton, Dilhar N. Samaraweera, G. Nalika N. de Silva, T.G.A.N. Chandrasena , et al. · 2017

We observed all three main OT genotypes in Sri Lanka, and the majority fell into Thai Karp related clade. These results demonstrate great antigenic diversity of OT in the studied areas of Sri Lanka.

Sporadic cases of adult measles: a research article Open

R. Premaratna, Nathasha Luke, H. M. U. A. S. Perera, M. P. M. L. Gunathilake, Pubudu Amarasena , et al. · 2017

At least a 3-5 day delay in the diagnosis was observed (even after the appearance of the rash in some patients), due to non-awareness of its occurrence, unfamiliarity of measles in adults, non-specific nature of the illness and non-availab…

Surveillance for transmission of lymphatic filariasis in Colombo and Gampaha districts of Sri Lanka following mass drug administration: Table 1. Open

T.G.A.N. Chandrasena, R. Premaratna, Dilhani Samarasekera, Nilanthi R. de Silva · 2016

Decline in bancroftian microfilaraemia (microfilaria rate 0.32% to zero) supports elimination, but re-emergence of brugian filariasisis (antibody rate, 1.6%; one microfilaria positive) is a cause for concern.

Rickettsial disease IFA-IgG titres in auto-immune diseases: What do they imply? Open

P. Balasooriya, Nuwan Bandara, T.G.A.N. Chandrasena, R. Premaratna · 2016

Background: Rickettsial infections are known to present mimicking autoimmune disorders. The gold standard diagnostic test for rickettsial diseases is based on the detection of IgM and or IgG antibodies against these infections by immuno-fl…

T.G.A.N. Chandrasena YOU? Author Swipe