Nils Bömer
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View article: RNA Therapeutics in Heart Failure
RNA Therapeutics in Heart Failure Open
RNA-based therapeutics, such as small interfering RNAs (siRNAs), antisense oligonucleotides (ASOs) and messenger RNAs (mRNAs) are promising therapeutics that offer new avenues for targeting molecular pathways underlying heart failure (HF) …
View article: CDK4/6 inhibitor ribociclib induces cardiotoxicity through impaired E2F1-regulated spliceosome assembly
CDK4/6 inhibitor ribociclib induces cardiotoxicity through impaired E2F1-regulated spliceosome assembly Open
Background Ribociclib, a novel chemotherapeutic agent for metastatic breast cancer, functions as a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor. Its mechanism of action involves the CDK4/6-Rb-E2F1 pathway. Ribociclib use has very recentl…
View article: Glutathione deficiency and heart failure: a systematic review of human and animal evidence
Glutathione deficiency and heart failure: a systematic review of human and animal evidence Open
View article: Phosphoproteomics of phospholamban R14del heart tissue reveals aberrant regulation of calcium handling and contractility
Phosphoproteomics of phospholamban R14del heart tissue reveals aberrant regulation of calcium handling and contractility Open
Background Phospholamban (PLN) p.Arg14del (R14del, R14Δ/+) is a pathogenic variant that can cause cardiomyopathy, characterized by abnormal sarcoplasmic reticulum (SR) clustering, ultimately leading to heart failure (HF). The exact pathoph…
View article: Peroxiredoxin‐4, a marker of systemic oxidative stress, is associated with incident heart failure
Peroxiredoxin‐4, a marker of systemic oxidative stress, is associated with incident heart failure Open
Aims Oxidative stress is known to be involved in the pathophysiology of heart failure (HF). To assess oxidative stress, direct quantification of reactive oxygen species would be ideal but this is not feasible due to their short half‐lives.…
View article: Identification of disease-specific pathways and modifiers in phospholamban R14del cardiomyopathy: rationale, design and baseline characteristics of DECIPHER-PLN cohort
Identification of disease-specific pathways and modifiers in phospholamban R14del cardiomyopathy: rationale, design and baseline characteristics of DECIPHER-PLN cohort Open
View article: Micronutrient Deficiencies in Heart Failure and Relationship with Exocrine Pancreatic Insufficiency
Micronutrient Deficiencies in Heart Failure and Relationship with Exocrine Pancreatic Insufficiency Open
Background: Micronutrient deficiencies are common and play a significant role in the prognosis of many chronic diseases, including heart failure (HF), but their prevalence in HF is not well known. As studies have traditionally focused on c…
View article: Branched-chain amino acids and their metabolites decrease human and rat hepatic stellate cell activation
Branched-chain amino acids and their metabolites decrease human and rat hepatic stellate cell activation Open
View article: IL‐17 is associated with disease severity and targetable inflammatory processes in heart failure
IL‐17 is associated with disease severity and targetable inflammatory processes in heart failure Open
Aims Heart failure (HF) is recognized as an inflammatory disease in which cytokines play an important role. In animal HF models, interleukin‐17A (IL‐17) has been linked to deterioration of cardiac function and fibrosis, whereas knock‐out o…
View article: Association of baseline and longitudinal changes in insulin‐like growth factor‐binding protein‐7 with the risk of incident heart failure: Data from the PREVEND study
Association of baseline and longitudinal changes in insulin‐like growth factor‐binding protein‐7 with the risk of incident heart failure: Data from the PREVEND study Open
Aim Senescence is a major risk factor for heart failure (HF), and insulin‐like growth factor‐binding protein‐7 (IGFBP7) has been identified as an important senescence‐inducing factor. The aim of this study was to examine the value of basel…
View article: 404‐error “Disease not found”: Unleashing the translational potential of ‐omics approaches beyond traditional disease classification in heart failure research
404‐error “Disease not found”: Unleashing the translational potential of ‐omics approaches beyond traditional disease classification in heart failure research Open
The emergence of personalized medicine, facilitated by the progress in ‐omics technologies, has initiated a new era in medical diagnostics and treatment. This review examines the potential of ‐omics approaches in heart failure, a condition…
View article: Proteomic and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes
Proteomic and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): Dutch Research Council, through the Open Competition ENW-KLEIN grant Background Low selenium concentrations are associated wi…
View article: CDK4/6 inhibitor ribociclib induces cardiotoxicity in dynamic engineered heart tissues, mitigated by E2F1 overexpression
CDK4/6 inhibitor ribociclib induces cardiotoxicity in dynamic engineered heart tissues, mitigated by E2F1 overexpression Open
Funding Acknowledgements Type of funding sources: Public grant(s) – EU funding. Main funding source(s): European Research Council CDK4/6 inhibitor Ribociclib induces cardiotoxicity in dynamic engineered heart tissues, mitigated by E2F1 ove…
View article: Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes
Biomarker and transcriptomics profiles of serum selenium concentrations in patients with heart failure are associated with immunoregulatory processes Open
These data suggest that immunoregulation is an important mechanism through which selenium might have beneficial roles in HF. The beneficial effects of higher serum selenium concentrations are likely because of global immunomodulatory effec…
View article: A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging
A review of the pathophysiological mechanisms of doxorubicin-induced cardiotoxicity and aging Open
View article: Glutathione Deficiency and Heart Failure: A Systematic Review of Human and Animal Evidence
Glutathione Deficiency and Heart Failure: A Systematic Review of Human and Animal Evidence Open
View article: A high-throughput screening strategy identifies adenosine 5'-monophosphate as a novel enhancing molecule of the cardio-protective enzyme 5-oxoprolinase (OPLAH)
A high-throughput screening strategy identifies adenosine 5'-monophosphate as a novel enhancing molecule of the cardio-protective enzyme 5-oxoprolinase (OPLAH) Open
Background/Introduction Oxidative stress plays an essential role in the pathophysiology of heart failure (HF), and reducing it might improve outcomes in patients suffering from it. We recently identified 5-oxoproline to be elevated in pati…
View article: Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D
Clinical characteristics and prognosis of patients with heart failure and high concentrations of interleukin-17D Open
View article: Immunomodulation and immunopharmacology in heart failure
Immunomodulation and immunopharmacology in heart failure Open
View article: Micronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND
Micronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND Open
View article: Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues
Evaluation of Senescence and Its Prevention in Doxorubicin-Induced Cardiotoxicity Using Dynamic Engineered Heart Tissues Open
Senescence was observed in the hearts of patients with severe doxorubicin-induced cardiotoxicity, and this phenotype can be modeled in vitro by exposing dyn-EHTs to repeated clinically relevant doses of doxorubicin. The senomorphic drugs 5…
View article: Editorial: Micro- and macronutrient malnutrition in cardiovascular disease
Editorial: Micro- and macronutrient malnutrition in cardiovascular disease Open
EDITORIAL article Front. Cardiovasc. Med., 04 May 2023Sec. Heart Failure and Transplantation Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1191982
View article: Clinical and prognostic associations of autoantibodies recognizing adrenergic/muscarinic receptors in patients with heart failure
Clinical and prognostic associations of autoantibodies recognizing adrenergic/muscarinic receptors in patients with heart failure Open
Aims The importance of autoantibodies (AABs) against adrenergic/muscarinic receptors in heart failure (HF) is not well-understood. We investigated the prevalence and clinical/prognostic associations of four AABs recognizing the M2-muscarin…
View article: IGF-1 boosts mitochondrial function by a Ca2+ uptake-dependent mechanism in cultured human and rat cardiomyocytes
IGF-1 boosts mitochondrial function by a Ca2+ uptake-dependent mechanism in cultured human and rat cardiomyocytes Open
A physiological increase in cardiac workload results in adaptive cardiac remodeling, characterized by increased oxidative metabolism and improvements in cardiac performance. Insulin-like growth factor-1 (IGF-1) has been identified as a cri…
View article: Trace element equilibrium in acute heart failure and the effect of empagliflozin
Trace element equilibrium in acute heart failure and the effect of empagliflozin Open
Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have shown to be potent therapeutic agents in heart failure (HF) irrespective of ejection fraction, improving cardiometabolic features and reducing risk of hospitalization for HF.1 Favoura…
View article: Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease
Sexual dimorphism in selenium deficiency is associated with metabolic syndrome and prevalence of heart disease Open
View article: Micronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND
Micronutrient deficiencies and new-onset atrial fibrillation in a community-based cohort: data from PREVEND Open
Background Impaired nutritional status has been linked to cardiovascular diseases. Both selenium and iron deficiency have been associated with impaired exercise tolerance and worse prognosis in patients with heart failure (HF) as well as m…
View article: Review: Precision Medicine Approaches for Genetic Cardiomyopathy: Targeting Phospholamban R14del
Review: Precision Medicine Approaches for Genetic Cardiomyopathy: Targeting Phospholamban R14del Open
Purpose of Review Heart failure is a syndrome with poor prognosis and no curative options for the majority of patients. The standard one-size-fits-all-treatment approach, targeting neurohormonal dysregulations, helps to modulate symptoms o…
View article: Selenium deficiency is associated with new-onset atrial fibrillation in PREVEND: a prospective general population cohort
Selenium deficiency is associated with new-onset atrial fibrillation in PREVEND: a prospective general population cohort Open
Funding Acknowledgements Type of funding sources: Public grant(s) – National budget only. Main funding source(s): A grant of the Dutch Kidney Foundation (E0.13)Dutch Research Council (NWO) Open Competition ENW-M grant (OCENW.KLEIN.483) Bac…
View article: Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism?
Micronutrient deficiencies in heart failure: Mitochondrial dysfunction as a common pathophysiological mechanism? Open
Heart failure is a devastating clinical syndrome, but current therapies are unable to abolish the disease burden. New strategies to treat or prevent heart failure are urgently needed. Over the past decades, a clear relationship has been es…