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View article: Context-specific targeting of focal adhesion kinase in brain tumors: lessons from glioblastoma and neurofibromatosis type 2-mutant meningioma
Context-specific targeting of focal adhesion kinase in brain tumors: lessons from glioblastoma and neurofibromatosis type 2-mutant meningioma Open
Focal adhesion kinase (FAK) has long been explored as a therapeutic target in glioblastoma (GBM) based on its overexpression and involvement in invasive signaling. However, clinical trials have consistently failed to show benefit - highlig…
View article: Correction: Lan et al. CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Cancers 2022, 14, 326
Correction: Lan et al. CRISPR-Cas9 Screen Identifies DYRK1A as a Target for Radiotherapy Sensitization in Pancreatic Cancer. Cancers 2022, 14, 326 Open
Error in Figure [...]
View article: A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis
A novel role of exostosin glycosyltransferase 2 (EXT2) in glioblastoma cell metabolism, radiosensitivity and ferroptosis Open
Glioblastoma (GBM) employs various strategies to resist therapy, resulting in poor patient survival. A key aspect of its survival mechanisms lies in metabolic regulation, maintaining rapid growth and evading cell death. Recent studies reve…
View article: Aqueous extracts from Dioscorea sansibarensis Pax show cytotoxic and radiosensitizing potential in 3D growing HPV-negative and HPV-positive human head and neck squamous cell carcinoma models
Aqueous extracts from Dioscorea sansibarensis Pax show cytotoxic and radiosensitizing potential in 3D growing HPV-negative and HPV-positive human head and neck squamous cell carcinoma models Open
Numerous natural substances have anti-cancer properties. Especially indigenous people use aqueous plant extracts for tea or ointments including Dioscorea sansibarensis Pax to treat various diseases. The aim of this study was to evaluate th…
View article: Influence of Bruton’s Tyrosine Kinase (BTK) on Epithelial–Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC)
Influence of Bruton’s Tyrosine Kinase (BTK) on Epithelial–Mesenchymal Transition (EMT) Processes and Cancer Stem Cell (CSC) Enrichment in Head and Neck Squamous Cell Carcinoma (HNSCC) Open
Constitutively active kinases play a crucial role in carcinogenesis, and their inhibition is a common target for molecular tumor therapy. We recently discovered the expression of two oncogenic isoforms of Bruton’s Tyrosine Kinase (BTK) in …
View article: Supplementary Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance
Supplementary Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance Open
Supplementary Figure Legends, Supplementary Table S1 and S2
View article: Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance
Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance Open
Pancreatic ductal adenocarcinoma (PDAC) stroma, composed of extracellular matrix (ECM) proteins, promotes therapy resistance and poor survival rate. Integrin-mediated cell/ECM interactions are well known to control cancer cell survival, pr…
View article: Supplementary Figure S1 - Figure S7Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance
Supplementary Figure S1 - Figure S7Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance Open
Supplementary Figure 1. Flowchart of high throughout screen (3D HTesiRNAS) in 3D PDAC organoids. Supplementary Figure 2. β8 integrin expression in cell fractions. Supplementary Figure 3. β8 integrin knockdown also radiosensitizes 2D PDAC c…
View article: Supplementary Figure S1 - Figure S7Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance
Supplementary Figure S1 - Figure S7Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance Open
Supplementary Figure 1. Flowchart of high throughout screen (3D HTesiRNAS) in 3D PDAC organoids. Supplementary Figure 2. β8 integrin expression in cell fractions. Supplementary Figure 3. β8 integrin knockdown also radiosensitizes 2D PDAC c…
View article: Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance
Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance Open
Pancreatic ductal adenocarcinoma (PDAC) stroma, composed of extracellular matrix (ECM) proteins, promotes therapy resistance and poor survival rate. Integrin-mediated cell/ECM interactions are well known to control cancer cell survival, pr…
View article: Supplementary Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance
Supplementary Data from β8 Integrin Mediates Pancreatic Cancer Cell Radiochemoresistance Open
Supplementary Figure Legends, Supplementary Table S1 and S2
View article: Supplementary Figures 1-8 from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells
Supplementary Figures 1-8 from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells Open
PDF file - 621K, Supplementary Figure S1. Treatment with Cetuximab inhibits EGF-mediated EGFR phosphorylation under 2D and 3D cell culture conditions in a cell line-dependent manner. Supplementary Figure S2. Induction of Cetuximab-mediated…
View article: Data from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis
Data from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis Open
Inherent and acquired resistance to targeted therapeutics continues to emerge as a major clinical obstacle. For example, resistance to EGF receptor targeting occurs commonly, more so than was expected, on the basis of preclinical work. Giv…
View article: Data from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis
Data from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis Open
Inherent and acquired resistance to targeted therapeutics continues to emerge as a major clinical obstacle. For example, resistance to EGF receptor targeting occurs commonly, more so than was expected, on the basis of preclinical work. Giv…
View article: Supplementary Figures 1-8 from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells
Supplementary Figures 1-8 from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells Open
PDF file - 621K, Supplementary Figure S1. Treatment with Cetuximab inhibits EGF-mediated EGFR phosphorylation under 2D and 3D cell culture conditions in a cell line-dependent manner. Supplementary Figure S2. Induction of Cetuximab-mediated…
View article: Supplementary Experimental Procedures and Figures and Tables from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis
Supplementary Experimental Procedures and Figures and Tables from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis Open
PDF file, 606K, Methods, Figures, Figure legends, Tables Fig. S1. A, EGFR protein expression in A549 and H1299 cells evaluated by Western blot. Fig. S2. A, A549 cells were cultured in the presence (+FCS) or absence (-FCS) of FCS and B, add…
View article: Data from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells
Data from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells Open
EGF receptor (EGFR) promotes tumor growth as well as radio- and chemoresistance in various human malignancies including squamous cell carcinomas (SCC). In addition to deactivation of prosurvival signaling, cetuximab-mediated EGFR targeting…
View article: Data from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification
Data from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification Open
Cell shape and architecture are determined by cell-extracellular matrix interactions and have profound effects on cellular behavior, chromatin condensation, and tumor cell resistance to radiotherapy and chemotherapy. To evaluate the role o…
View article: Data from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells
Data from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells Open
EGF receptor (EGFR) promotes tumor growth as well as radio- and chemoresistance in various human malignancies including squamous cell carcinomas (SCC). In addition to deactivation of prosurvival signaling, cetuximab-mediated EGFR targeting…
View article: Data from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification
Data from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification Open
Cell shape and architecture are determined by cell-extracellular matrix interactions and have profound effects on cellular behavior, chromatin condensation, and tumor cell resistance to radiotherapy and chemotherapy. To evaluate the role o…
View article: Supplementary Methods, Figures 1-15, Tables 1-9 from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification
Supplementary Methods, Figures 1-15, Tables 1-9 from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification Open
Supplementary Methods, Figures 1-15, Tables 1-9 from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification
View article: Supplementary Methods , Figure Legends 1-8, Tables 1-3 from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells
Supplementary Methods , Figure Legends 1-8, Tables 1-3 from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells Open
PDF file - 109K, Supplementary Table S1. Plating efficiencies of SCC cells differ between 2D and 3D cell culture conditions cell line-dependently. Supplementary Table S2. JIP-4, Grb2 and STE20-like kinase bind to EGFR in untreated FaDu 3D …
View article: Supplementary Methods, Figures 1-15, Tables 1-9 from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification
Supplementary Methods, Figures 1-15, Tables 1-9 from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification Open
Supplementary Methods, Figures 1-15, Tables 1-9 from Three-Dimensional Cell Growth Confers Radioresistance by Chromatin Density Modification
View article: Supplementary Methods , Figure Legends 1-8, Tables 1-3 from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells
Supplementary Methods , Figure Legends 1-8, Tables 1-3 from EGFR/JIP-4/JNK2 Signaling Attenuates Cetuximab-Mediated Radiosensitization of Squamous Cell Carcinoma Cells Open
PDF file - 109K, Supplementary Table S1. Plating efficiencies of SCC cells differ between 2D and 3D cell culture conditions cell line-dependently. Supplementary Table S2. JIP-4, Grb2 and STE20-like kinase bind to EGFR in untreated FaDu 3D …
View article: Supplementary Experimental Procedures and Figures and Tables from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis
Supplementary Experimental Procedures and Figures and Tables from Cetuximab Attenuates Its Cytotoxic and Radiosensitizing Potential by Inducing Fibronectin Biosynthesis Open
PDF file, 606K, Methods, Figures, Figure legends, Tables Fig. S1. A, EGFR protein expression in A549 and H1299 cells evaluated by Western blot. Fig. S2. A, A549 cells were cultured in the presence (+FCS) or absence (-FCS) of FCS and B, add…
View article: Simultaneous inhibition of discoidin domain receptor 1 and integrin αVβ3 radiosensitizes human glioblastoma cells.
Simultaneous inhibition of discoidin domain receptor 1 and integrin αVβ3 radiosensitizes human glioblastoma cells. Open
Glioblastomas (GBM) are the most common primary brain tumors in adults and associated with poor clinical outcomes due to therapy resistances and destructive growth. Interactions of cancer cells with the extracellular matrix (ECM) play a pi…
View article: Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance
Partial Reduction in BRCA1 Gene Dose Modulates DNA Replication Stress Level and Thereby Contributes to Sensitivity or Resistance Open
BRCA1 is a well-known breast cancer risk gene, involved in DNA damage repair via homologous recombination (HR) and replication fork protection. Therapy resistance was linked to loss and amplification of the BRCA1 gene causing inferior surv…