Nils Erik Gilhus
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View article: Network connectivity, between-study heterogeneity and timepoint challenges in generalized myasthenia gravis: a feasibility assessment of indirect treatment comparisons
Network connectivity, between-study heterogeneity and timepoint challenges in generalized myasthenia gravis: a feasibility assessment of indirect treatment comparisons Open
Aim: We performed a feasibility assessment to systematically evaluate randomized controlled trials (RCTs) for generalized myasthenia gravis (gMG) treatments. The goal was to identify the advantages and disadvantages of different indirect t…
View article: Toward European harmonization of national myasthenia gravis registries: modified Delphi procedure-based expert consensus on collectable data
Toward European harmonization of national myasthenia gravis registries: modified Delphi procedure-based expert consensus on collectable data Open
Background Myasthenia gravis (MG) is a rare autoimmune disorder. Several new treatment concepts have emerged in recent years, but access to these treatments varies due to differing national reimbursement regulations, leading to disparities…
View article: Postpolio-syndrom må få mer oppmerksomhet
Postpolio-syndrom må få mer oppmerksomhet Open
View article: Migraine in the multiple sclerosis prodrome: a prospective nationwide cohort study in pregnant women
Migraine in the multiple sclerosis prodrome: a prospective nationwide cohort study in pregnant women Open
View article: Medical costs of treating myasthenia gravis in patients who need intravenous immunoglobulin (IVIg) – a register-based study
Medical costs of treating myasthenia gravis in patients who need intravenous immunoglobulin (IVIg) – a register-based study Open
Background Several innovative treatments are expected for myasthenia gravis (MG) in the coming years. Healthcare payers usually require cost-effectiveness analyses before reimbursement. We aimed to investigate resource utilization and dire…
View article: High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study
High‐dose folic acid use and cancer risk in women who have given birth: A register‐based cohort study Open
Objective This study was undertaken to study whether high‐dose folic acid ( > 1 mg daily) use is associated with an increased risk of cancer in all women who have given birth and in women with epilepsy. High‐dose folic acid supplementation…
View article: Biological biomarkers in muscle diseases relevant for follow-up and evaluation of treatment
Biological biomarkers in muscle diseases relevant for follow-up and evaluation of treatment Open
Muscle diseases cover a diverse group of disorders that, in most cases, are hereditary. The rarity of the individual muscle diseases provides a challenge for researchers when wanting to establish natural history of the conditions and when …
View article: Risk of Perinatal and Maternal Morbidity and Mortality Among Pregnant Women With Epilepsy
Risk of Perinatal and Maternal Morbidity and Mortality Among Pregnant Women With Epilepsy Open
Importance Maternal epilepsy is associated with adverse pregnancy and neonatal outcomes. A better understanding of this condition and the associated risk of mortality and morbidity at the time of delivery could help reduce adverse outcomes…
View article: Socioeconomic differences in use of antiseizure medication in pregnancies with maternal epilepsy: A population‐based study from Nordic universal health care systems
Socioeconomic differences in use of antiseizure medication in pregnancies with maternal epilepsy: A population‐based study from Nordic universal health care systems Open
Objective Research points to disparities in disease burden and access to medical care in epilepsy. We studied the association between socioeconomic status (SES) and antiseizure medication (ASM) use in pregnancies with maternal epilepsy. Me…
View article: Prescribing patterns for higher dose folic acid in pregnant women with epilepsy treated with antiseizure medication
Prescribing patterns for higher dose folic acid in pregnant women with epilepsy treated with antiseizure medication Open
Objective This study was undertaken to characterize the use of higher doses of folic acid (≥1 mg daily) in relation to pregnancy in Denmark, Norway, and Sweden in women with epilepsy treated with antiseizure medication (ASM). Methods In th…
View article: Transient Neonatal Myasthenia Gravis as a Common Complication of a Rare Disease: A Systematic Review
Transient Neonatal Myasthenia Gravis as a Common Complication of a Rare Disease: A Systematic Review Open
Myasthenia gravis (MG) is a rare autoimmune disease. Transient neonatal myasthenia gravis (TNMG) is caused by pathogenic maternal autoantibodies that cross the placenta and disrupt signaling at the neuromuscular junction. This is a systema…
View article: Systematic review of the patient burden of generalised myasthenia gravis in Europe, the Middle East, and Africa
Systematic review of the patient burden of generalised myasthenia gravis in Europe, the Middle East, and Africa Open
View article: Prenatal exposure to antiseizure medications and fetal growth: a population-based cohort study from the Nordic countries
Prenatal exposure to antiseizure medications and fetal growth: a population-based cohort study from the Nordic countries Open
The NordForsk Nordic Program on Health and Welfare (83539), the Independent Research Fund Denmark (1133-00026B), the Danish Epilepsy Association, the Central Denmark Region, the Novo Nordisk Foundation (NNF16OC0019126 and NNF22OC0075033), …
View article: The epidemiology and societal costs of myasthenia gravis in Norway: A non‐interventional study using national registry data
The epidemiology and societal costs of myasthenia gravis in Norway: A non‐interventional study using national registry data Open
Background and purpose With the emergence of new treatment options for myasthenia gravis (MG), there is a need for information regarding epidemiology, healthcare utilization, and societal costs to support economic evaluation and identify e…
View article: Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment
Generalized myasthenia gravis with acetylcholine receptor antibodies: A guidance for treatment Open
Background Generalized myasthenia gravis (MG) with antibodies against the acetylcholine receptor is a chronic disease causing muscle weakness. Access to novel treatments warrants authoritative treatment recommendations. The Nordic countrie…
View article: Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms
Adverse Childhood Experiences and the Risk of Multiple Sclerosis Development: A Review of Potential Mechanisms Open
Adverse childhood experiences (ACEs), such as abuse, neglect, and household dysfunction, contribute to long-term systemic toxic stress and inflammation that may last well into adulthood. Such early-life stressors have been associated with …
View article: Diurnal cognitive functioning in patients with myasthenia gravis with the role of chronotype and depression: a pilot study
Diurnal cognitive functioning in patients with myasthenia gravis with the role of chronotype and depression: a pilot study Open
The data obtained show that diurnal neuropsychological performance in MG patients is associated with depression. Routine assessment and treatment of mood disorders could significantly improve cognitive functioning in myasthenia gravis pati…
View article: Editorial: Phenotypes of myasthenia gravis, volume II
Editorial: Phenotypes of myasthenia gravis, volume II Open
EDITORIAL article Front. Neurol., 24 November 2023Sec. Neuromuscular Disorders and Peripheral Neuropathies Volume 14 - 2023 | https://doi.org/10.3389/fneur.2023.1335308
View article: Case report: Seropositive myasthenia gravis complicated by limbic encephalitis positive for antibodies to AMPAR and Lgi1
Case report: Seropositive myasthenia gravis complicated by limbic encephalitis positive for antibodies to AMPAR and Lgi1 Open
Objectives Autoantibodies to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and leucine-rich glioma-inactivated 1 (Lgi1) are associated with autoimmune encephalitis. We described an acetylcholine receptor (AChR)-…
View article: Altered Cardiac Autonomic Regulation in Individuals with Myasthenia Gravis—A Systematic Review and Meta-Analysis
Altered Cardiac Autonomic Regulation in Individuals with Myasthenia Gravis—A Systematic Review and Meta-Analysis Open
The aim of this systematic review with meta-analysis was to determine differences in cardiovascular autonomic parameters between patients with myasthenia gravis (MG) and healthy controls (HCs). Two reviewers searched four electronic databa…
View article: Diagnosis and therapy of myasthenia gravis—the patients’ perspective: a cross-sectional study
Diagnosis and therapy of myasthenia gravis—the patients’ perspective: a cross-sectional study Open
The survey aimed to explore patients’ perspectives with myasthenia gravis (MG) toward the diagnosis made and the therapy used to treat MG. The survey was conducted with a quantitative method, using the CAWI technique. A total of 321 people…
View article: High‐dose folic acid and cancer risk; unjustified concerns by von Wrede and colleagues regarding our paper
High‐dose folic acid and cancer risk; unjustified concerns by von Wrede and colleagues regarding our paper Open
Women using antiseizure medication in pregnancy are often advised to use high doses of folic acid supplements (1mg to 5 mg) to reduce the risk of teratogenicity. Recently, we published a report showing an association between maternal presc…
View article: Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis
Occurrence and severity of myasthenic crisis in an unselected Turkish cohort of patients with myasthenia gravis Open
Myasthenia gravis (MG) is a disorder of the neuromuscular junction that can deteriorate into myasthenic crisis, involving weakness of bulbar and respiratory muscles. In this study, we describe the clinical manifestations of myasthenic cris…
View article: Pregnancy, folic acid, and antiseizure medication
Pregnancy, folic acid, and antiseizure medication Open
Background Although some antiseizure medications (ASMs) are teratogenic, most people with epilepsy need treatment in pregnancy. The risk of ASM fetotoxicity may be mitigated with folic acid. High-dose folic acid supplementation has traditi…
View article: Spike count and morphology in the classification of epileptiform discharges
Spike count and morphology in the classification of epileptiform discharges Open
Purpose The purpose of this study is to investigate the impact of Bergen Epileptiform Morphology Score (BEMS) and interictal epileptiform discharge (IED) candidate count in EEG classification. Methods We included 400 consecutive patients f…
View article: Does maternal genetic liability to folate deficiency influence the risk of antiseizure medication-associated language impairment and autistic traits in children of women with epilepsy?
Does maternal genetic liability to folate deficiency influence the risk of antiseizure medication-associated language impairment and autistic traits in children of women with epilepsy? Open
View article: Myasthenia gravis, respiratory function, and respiratory tract disease
Myasthenia gravis, respiratory function, and respiratory tract disease Open
View article: Harald Nyland
Harald Nyland Open
View article: Fetal Growth Restriction After Prenatal Exposure to Antiseizure Medication
Fetal Growth Restriction After Prenatal Exposure to Antiseizure Medication Open
View article: Oversiktlig kompendium i nevrologi for studenter
Oversiktlig kompendium i nevrologi for studenter Open