Nils Hellwig
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View article: LILBID-MS: using lasers to shed light on biomolecular architectures
LILBID-MS: using lasers to shed light on biomolecular architectures Open
Structural Biology has moved beyond the aim of simply identifying the components of a cellular subsystem towards analysing the dynamics and interactions of multiple players within a cell. This focal shift comes with additional requirements…
View article: Assembly and Functional Role of PACE Transporter PA2880 from Pseudomonas aeruginosa
Assembly and Functional Role of PACE Transporter PA2880 from Pseudomonas aeruginosa Open
Pseudomonas aeruginosa is a pathogen that causes hospital-acquired (nosocomial) infections, such as ventilator-associated pneumonia and sepsis syndromes. Chlorhexidine diacetate is a disinfectant used for bacterial control in various envir…
View article: Molecular and Low-Resolution Structural Characterization of the Na+-Translocating Glutaconyl-CoA Decarboxylase From Clostridium symbiosum
Molecular and Low-Resolution Structural Characterization of the Na+-Translocating Glutaconyl-CoA Decarboxylase From Clostridium symbiosum Open
Some anaerobic bacteria use biotin-dependent Na+-translocating decarboxylases (Bdc) of β-keto acids or their thioester analogs as key enzymes in their energy metabolism. Glutaconyl-CoA decarboxylase (Gcd), a member of this protein family, …
View article: LILBID and nESI: Different Native Mass Spectrometry Techniques as Tools in Structural Biology
LILBID and nESI: Different Native Mass Spectrometry Techniques as Tools in Structural Biology Open
Native mass spectrometry is applied for the investigation of proteins and protein complexes worldwide. The challenge in native mass spectrometry is maintaining the features of the proteins of interest, such as oligomeric state, bound ligan…
View article: Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs
Native mass spectrometry goes more native: investigation of membrane protein complexes directly from SMALPs Open
Other than more widely used methods, the use of styrene maleic acid copolymers allows the direct extraction of membrane proteins from the lipid bilayer into SMALPs keeping it in its native lipid surrounding.
View article: Mapping light-driven conformational changes within the photosensory module of plant phytochrome B
Mapping light-driven conformational changes within the photosensory module of plant phytochrome B Open
Organisms developed different photoreceptors to be able to adapt to changing environmental light conditions. Phytochromes are red/far-red (r/fr) photochromic photoreceptors that belong to the classical photoreceptors along with cryptochrom…