Nathan Herrmann
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View article: Validity of the International Classification of Diseases, 10th Revision codes for lithium toxicity in adult patients at hospital admission: a cohort study in Canada
Validity of the International Classification of Diseases, 10th Revision codes for lithium toxicity in adult patients at hospital admission: a cohort study in Canada Open
Objective To assess the validity of the International Classification of Diseases, 10th Revision (ICD-10) healthcare database diagnosis codes for lithium toxicity at hospital admission in Ontario, Canada. Design Population-based retrospecti…
View article: sprynger: Scriptable bibliometrics using a Python interface to Springer Nature
sprynger: Scriptable bibliometrics using a Python interface to Springer Nature Open
We present a wrapper for the Springer Nature RESTful API written for Python 3. The wrapper allows users to access their free-to-use endpoints via user-friendly interfaces and can be used without prior knowledge of RESTful APIs. The APIs al…
View article: Brain glutathione in vascular mild cognitive impairment and cognitive correlates
Brain glutathione in vascular mild cognitive impairment and cognitive correlates Open
Background Oxidative stress (OS) has been implicated in age‐related neurodegeneration and may be important in prodromal states such as vascular mild cognitive impairment (vMCI). Higher peripheral OS is reported in vMCI patients; however, t…
View article: Lipid peroxidation in patients with vascular mild cognitive impairment from a memory and antioxidants in vascular impairment trial (MOVE‐IT)
Lipid peroxidation in patients with vascular mild cognitive impairment from a memory and antioxidants in vascular impairment trial (MOVE‐IT) Open
Background Oxidative stress (OS) has been a target of interest for vascular dementia, given its implications in pathogenesis. OS may be important in prodromal stage, such as vascular mild cognitive impairment (vMCI), and examining OS marke…
View article: Changes in Brain Glutathione in patients with mild vascular cognitive impairment
Changes in Brain Glutathione in patients with mild vascular cognitive impairment Open
Background Oxidative stress (OS) has been implicated in age‐related neurodegeneration and may be important in prodromal states such as mild vascular cognitive impairment (mVCI). Higher peripheral OS is reported in mVCI patients; however, t…
View article: Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults
Mild cognitive impairment and major depressive disorder are associated with molecular senescence abnormalities in older adults Open
Introduction The biological mechanisms linking mild cognitive impairment (MCI) and major depressive disorder are not well understood. We investigated whether molecular senescence changes in older adults are associated with a history of maj…
View article: Theta‐gamma coupling and ApoE genotype in patients at risk for Alzheimer’s dementia
Theta‐gamma coupling and ApoE genotype in patients at risk for Alzheimer’s dementia Open
Background Theta‐gamma coupling (TGC) is an electroencephalography (EEG) marker of working memory and depends on robust synaptic plasticity within the recurrent prefrontal cortical networks (Rajji et al. 2017, Buszaski et al. 2012). ApoE4 …
View article: Investigating the relationship between neuropsychiatric symptoms and cognition in mild cognitive impairment and Alzheimer’s disease patients undergoing an exercise‐primed transcranial direct current stimulation clinical trial (The EXPRESS Study)
Investigating the relationship between neuropsychiatric symptoms and cognition in mild cognitive impairment and Alzheimer’s disease patients undergoing an exercise‐primed transcranial direct current stimulation clinical trial (The EXPRESS Study) Open
Background Neuropsychiatric symptoms (NPS) are common features of Mild Cognitive Impairment (MCI) and Alzheimer’s disease (AD), and are associated with poorer cognition. Transcranial direct current stimulation (tDCS), a non‐invasive type o…
View article: Therapeutic trial design for frontotemporal dementia and related disorders
Therapeutic trial design for frontotemporal dementia and related disorders Open
The frontotemporal dementia (FTD) spectrum is a heterogeneous group of neurodegenerative syndromes with overlapping clinical, molecular and pathological features, all of which challenge the design of clinical trials in these conditions. To…
View article: Comparison of prescribing practices for older adults treated by female versus male physicians: A retrospective cohort study
Comparison of prescribing practices for older adults treated by female versus male physicians: A retrospective cohort study Open
There is a statistically significant and important difference in ChEI prescribing patterns between female and male physicians, suggesting that female physicians may be more careful and conservative in their approaches. This will inform fut…
View article: Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound Open
Magnetic resonance-guided focused ultrasound in combination with intravenously injected microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta-amyloid and tau pathology in animal models of Alzheimer’s dise…
View article: Pharmacological interventions for apathy in Alzheimer's disease
Pharmacological interventions for apathy in Alzheimer's disease Open
Methylphenidate may demonstrate a benefit for apathy and may have slight benefits for cognition and functional performance in people with AD, but this finding is associated with low-quality evidence. Our meta-analysis is limited by the sma…
View article: Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis
Peripheral Alterations in Cytokine and Chemokine Levels After Antidepressant Drug Treatment for Major Depressive Disorder: Systematic Review and Meta-Analysis Open
Mounting evidence suggests that aberrations in immune-inflammatory pathways contribute to the pathophysiology of major depressive disorder (MDD), and individuals with MDD may have elevated levels of predominantly pro-inflammatory cytokines…
View article: Dataset for: The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor (BDNF) in healthy adults: A meta-analysis
Dataset for: The effect of acute exercise on blood concentrations of brain-derived neurotrophic factor (BDNF) in healthy adults: A meta-analysis Open
It has been hypothesized that one mechanism through which physical activity provides benefits to cognition and mood is via increasing brain-derived neurotrophic factor (BDNF) concentrations. Some studies have reported immediate benefits to…
View article: Dr Mazereeuw and Colleagues Reply
Dr Mazereeuw and Colleagues Reply Open
Article Abstract Because this piece does not have an abstract, we have provided for your benefit the first 3 sentences of the full text. To the Editor: We thank the Editor for the opportunity to respond to Dr Tan's letter, which used our r…