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View article: Photoactivatable and Photolabile Pharmacophores: Lessons Learned from Capsaicin
Photoactivatable and Photolabile Pharmacophores: Lessons Learned from Capsaicin Open
Light-controlled molecules have become valuable tools for studying biological systems offering an unparalleled control in space and time. Specifically, the remote-controllable (de)activation of small molecules is attractive to both study m…
View article: Photoactivatable and photolabile pharmacophores: lessons learned from capsaicin
Photoactivatable and photolabile pharmacophores: lessons learned from capsaicin Open
Structurally merging light-susceptible with bioactive molecules allows to generate photolabile chromopharmacophores. Using capsaicinoids, chromopharmacophores could activate the TRPV1 channel, while no activation is observed for the photop…
View article: Light-Control of Biomimetic and Bioactive Molecules
Light-Control of Biomimetic and Bioactive Molecules Open
Light-controlled molecules enable precise spatial and temporal regulation of biological activity, supporting both fundamental research and the development of new therapeutics. In this work, photolipids and photocaged bioactive compounds we…
View article: NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals
NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals Open
Fluorescence microscopy has long been a transformative technique in biological sciences. Nevertheless, most implementations are limited to a few targets, which have been revealed using primary antibodies and fluorescently conjugated second…
View article: NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals
NanoPlex: a universal strategy for fluorescence microscopy multiplexing using nanobodies with erasable signals Open
Fluorescence microscopy has long been a transformative technique in biological sciences. Nevertheless, most implementations are limited to a few targets, revealed using primary antibodies (1.Abs) and fluorescently conjugated secondary anti…