Nils Lehmann
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View article: Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism
Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism Open
Excessive fibroblast proliferation and metabolic reprogramming are hallmarks of pathological cardiac remodeling, contributing significantly to impaired cardiac function. This study investigates the role of circular RNAs (circRNAs) in fibro…
View article: Patterns of follow‐up care in adult blood cancer survivors—Prospective evaluation of health‐related outcomes, resource use, and quality of life
Patterns of follow‐up care in adult blood cancer survivors—Prospective evaluation of health‐related outcomes, resource use, and quality of life Open
Background Information about follow‐up care in blood cancer survivors is limited. The questionnaire‐based “Aftercare in Blood Cancer Survivors” (ABC) study aimed to identify patterns of follow‐up care in Germany and compare different types…
View article: Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals with Prediabetes: A Multi-Cohort Study
Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals with Prediabetes: A Multi-Cohort Study Open
Objectives: To describe the epidemiology and prognostic value of the coronary artery calcium (CAC) among individuals with prediabetes. Research Design and Methods: We pooled participants free of clinical ASCVD from 4 prospective cohorts Mu…
View article: Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals with Prediabetes: A Multi-Cohort Study
Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals with Prediabetes: A Multi-Cohort Study Open
Objectives: To describe the epidemiology and prognostic value of the coronary artery calcium (CAC) among individuals with prediabetes. Research Design and Methods: We pooled participants free of clinical ASCVD from 4 prospective cohorts Mu…
View article: Supplementary Material for: Health-related complications during follow-up and their impact on blood cancer survivors – results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study
Supplementary Material for: Health-related complications during follow-up and their impact on blood cancer survivors – results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study Open
Introduction Blood cancer survivors are at increased risk for medical complications. Methods Our questionnaire-based study involved 1,551 blood cancer survivors with a ≥3-year interval since the last intense treatment. Its goal was to quan…
View article: Supplementary Material for: Health-related complications during follow-up and their impact on blood cancer survivors – results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study
Supplementary Material for: Health-related complications during follow-up and their impact on blood cancer survivors – results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study Open
Introduction Blood cancer survivors are at increased risk for medical complications. Methods Our questionnaire-based study involved 1,551 blood cancer survivors with a ≥3-year interval since the last intense treatment. Its goal was to quan…
View article: Improving 10-year cardiovascular risk prediction in apparently healthy people: flexible addition of risk modifiers on top of SCORE2
Improving 10-year cardiovascular risk prediction in apparently healthy people: flexible addition of risk modifiers on top of SCORE2 Open
Aims In clinical practice, factors associated with cardiovascular disease (CVD) like albuminuria, education level, or coronary artery calcium (CAC) are often known, but not incorporated in cardiovascular risk prediction models. The aims of…
View article: Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event
Analysis of fatality impact and seroprevalence surveys in a community sustaining a SARS-CoV-2 superspreading event Open
There is an ongoing debate on the COVID-19 infection fatality rate (IFR) and the impact of COVID-19 on overall population mortality. Here, we addressed these issues in a community in Germany with a major superspreader event analyzing death…
View article: Association of regional white matter hyperintensities with hypertension and cognition in the population‐based <scp>1000BRAINS</scp> study
Association of regional white matter hyperintensities with hypertension and cognition in the population‐based <span>1000BRAINS</span> study Open
Background White matter hyperintensities of presumed vascular origin (WMH) are frequent in cerebral magnetic resonance imaging of older people. They are promoted by vascular risk factors, especially hypertension, and are associated with co…
View article: The value of additional risk factors for improving 10-year cardiovascular risk prediction in apparently healthy people
The value of additional risk factors for improving 10-year cardiovascular risk prediction in apparently healthy people Open
Background In clinical practice, factors known to be associated with cardiovascular disease (CVD) like albuminuria, education level, or coronary calcium score are not directly incorporated in cardiovascular risk prediction models. The aim …
View article: Periventricular rather than deep white matter hyperintensities mediate effects of hypertension on cognitive performance in the population-based 1000BRAINS study
Periventricular rather than deep white matter hyperintensities mediate effects of hypertension on cognitive performance in the population-based 1000BRAINS study Open
Objectives: White matter hyperintensities (WMH) of presumed vascular origin are frequent in cerebral MRI of older people. They represent a sign of small vessel disease, are promoted by arterial hypertension, and relate to cognitive deficit…
View article: Coronary Artery Calcium Score to Refine the Use of PCSK9i in Asymptomatic Individuals: A Multicohort Study
Coronary Artery Calcium Score to Refine the Use of PCSK9i in Asymptomatic Individuals: A Multicohort Study Open
Background The value of coronary artery calcium (CAC) in the allocation of PCSK9i (proprotein convertase subtilisin/kexin type 9 inhibitors) among individuals without clinically evident atherosclerotic cardiovascular disease (ASCVD) is unk…
View article: Dynamics, outcomes and prerequisites of the first SARS-CoV-2 superspreading event in Germany in February 2020: a cross-sectional epidemiological study
Dynamics, outcomes and prerequisites of the first SARS-CoV-2 superspreading event in Germany in February 2020: a cross-sectional epidemiological study Open
Objectives The first German SARS-CoV-2 outbreak was a superspreading event in Gangelt, North Rhine-Westphalia, during indoor carnival festivities called ‘Kappensitzung’ (15 February 2020). We determined SARS-CoV-2 RT-PCR positivity rate, S…
View article: TSH concentrations in parents and their offspring: a cross-sectional family-based analysis
TSH concentrations in parents and their offspring: a cross-sectional family-based analysis Open
Objective Studies that evaluated the genetic influences on thyroid-stimulating hormone (TSH) concentrations were primarily performed in twin cohorts. The aim of this study was to investigate the sex-specific association of serum TSH concen…
View article: Association of Blood Pressure, Its Treatment, and Treatment Efficacy With Volume of White Matter Hyperintensities in the Population-Based 1000BRAINS Study
Association of Blood Pressure, Its Treatment, and Treatment Efficacy With Volume of White Matter Hyperintensities in the Population-Based 1000BRAINS Study Open
White matter hyperintensities (WMHs) of presumed vascular origin are a frequent finding in cerebral magnetic resonance imaging of older people. They are attributed to small vessel disease and involved in the pathogenesis of cognitive decli…
View article: Analysis of the Dynamics, Outcome, and Prerequisites of the first German SARS-CoV-2 Superspreading Event
Analysis of the Dynamics, Outcome, and Prerequisites of the first German SARS-CoV-2 Superspreading Event Open
Background The beginning of the COVID-19 pandemic was shaped by superspreading events including large-scale outbreaks. In Germany the first SARS-CoV-2 outbreak was a superspreading event in a rural area during indoor carnival festivities i…
View article: Population impact of different hypertension management guidelines based on the prospective population-based Heinz Nixdorf Recall study
Population impact of different hypertension management guidelines based on the prospective population-based Heinz Nixdorf Recall study Open
Objective Hypertension guidelines strongly differ between societies. The current American College of Cardiology/American Heart Association (ACC/AHA) guideline recommends higher proportions of the general population for antihypertensive med…
View article: Air Pollution and Progression of Atherosclerosis in Different Vessel Beds—Results from a Prospective Cohort Study in the Ruhr Area, Germany
Air Pollution and Progression of Atherosclerosis in Different Vessel Beds—Results from a Prospective Cohort Study in the Ruhr Area, Germany Open
Our study suggests that development and progression of subclinical atherosclerosis is associated with long-term air pollution in middle-aged participants with no or minor atherosclerotic burden at baseline, while overall no consistent asso…
View article: Genetic risk scores for coronary artery disease and its traditional risk factors: Their role in the progression of coronary artery calcification—Results of the Heinz Nixdorf Recall study
Genetic risk scores for coronary artery disease and its traditional risk factors: Their role in the progression of coronary artery calcification—Results of the Heinz Nixdorf Recall study Open
The association of the CAC genetic risk score and the CAD genetic risk score provides evidence that genetic determinants for CAC and CAD influence the progression of CAC.
View article: Association of social relationships with incident cardiovascular events and all-cause mortality
Association of social relationships with incident cardiovascular events and all-cause mortality Open
Objective To examine how different aspects of social relationships are associated with incident cardiovascular events and all-cause mortality. Methods In 4139 participants from the population-based Heinz Nixdorf Recall study without previo…
View article: Fertility preservation and fulfillment of parenthood after treatment of hematological malignancies: results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study
Fertility preservation and fulfillment of parenthood after treatment of hematological malignancies: results from the ‘Aftercare in Blood Cancer Survivors’ (ABC) study Open
Purpose Treatment of hematological malignancies carries the risk of lasting sterility. We aimed to identify fertility-related unmet needs. Methods The ‘Aftercare in Blood Cancer Survivors’ study is a cohort study of hematological patients …
View article: Cardiovascular Risk and Atherosclerosis Progression in Hypertensive Persons Treated to Blood Pressure Targets
Cardiovascular Risk and Atherosclerosis Progression in Hypertensive Persons Treated to Blood Pressure Targets Open
Arterial hypertension promotes atherosclerosis and cardiovascular events. We evaluated how cardiovascular risk and atherosclerosis progression are associated with blood pressure, antihypertensive treatment, and treatment efficacy. In 3555 …