Nils Steinacker
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View article: Intraoperative Confocal Laser Endomicroscopy Detects Prostate Cancer at the Single-Cell Level with High Specificity and in Real Time: A Preclinical Proof of Concept
Intraoperative Confocal Laser Endomicroscopy Detects Prostate Cancer at the Single-Cell Level with High Specificity and in Real Time: A Preclinical Proof of Concept Open
In prostate cancer (PCa) surgery, precise tumor margin identification remains challenging despite advances in surgical techniques. This study evaluates the combination of tumor-specific near-infrared imaging with the PSMA-targeting molecul…
View article: 2-[18F]F-<i>p</i>-Aminobenzoic Acid Specifically Detects Infective Endocarditis in Positron Emission Tomography
2-[18F]F-<i>p</i>-Aminobenzoic Acid Specifically Detects Infective Endocarditis in Positron Emission Tomography Open
Background Infective endocarditis (IE) is a life-threatening disease with high mortality, particularly when caused by Staphylococcus aureus (S aureus). Traditional diagnosis relies on clinical assessment, blood cultures, and imaging (eg, e…
View article: Reserpine-induced rat model for depression: Behavioral, physiological and PET-based dopamine receptor availability validation
Reserpine-induced rat model for depression: Behavioral, physiological and PET-based dopamine receptor availability validation Open
The longitudinal design of the study demonstrated that chronic RES administration induced striatal dopamine depletion that persisted even after the wash-out period. However, the behavior phenotype observed were transient. The data suggest …
View article: Exploring the role of combined external beam radiotherapy and targeted radioligand therapy with [<sup>177</sup>Lu]Lu-PSMA-617 for prostate cancer - from bench to bedside
Exploring the role of combined external beam radiotherapy and targeted radioligand therapy with [<sup>177</sup>Lu]Lu-PSMA-617 for prostate cancer - from bench to bedside Open
Management of prostate cancer (PC) might be improved by combining external beam radiotherapy (EBRT) and prostate-specific membrane antigen (PSMA)-targeted radioligand therapy (RLT) with lutetium-177 (177Lu)-labeled PSMA inhibito…
View article: Reserpine-induced rat model of depression: behavioral, physiological and dopamine receptor PET based validation
Reserpine-induced rat model of depression: behavioral, physiological and dopamine receptor PET based validation Open
Background. Reserpine, a monoamine depleting agent, has been used in preclinical research for many years to create animal models of depression and to test experimental antidepressant strategies. Nevertheless, evidence of the potential use …
View article: A New Class of PSMA-617-Based Hybrid Molecules for Preoperative Imaging and Intraoperative Fluorescence Navigation of Prostate Cancer
A New Class of PSMA-617-Based Hybrid Molecules for Preoperative Imaging and Intraoperative Fluorescence Navigation of Prostate Cancer Open
The development of PSMA-targeting low-molecular-weight hybrid molecules aims at advancing preoperative imaging and accurate intraoperative fluorescence guidance for improved diagnosis and therapy of prostate cancer. In hybrid probe design,…