Nilton Carlos Machado
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View article: Association of serum inflammasome proteins and pediatric traumatic brain injury severity
Association of serum inflammasome proteins and pediatric traumatic brain injury severity Open
Background Pediatric traumatic brain injury (pTBI) often leads to cognitive, behavioral, and motor impairments. NLRP3 inflammasome proteins, such as ASC and caspase-1, may serve as biomarkers for TBI severity due to their role in neuroinfl…
View article: Abdominal Migraine in Children and Adolescents at a Single Tertiary Pediatric Gastroenterology Center: A Twelve-yea Experience on Clinical and Therapeutic Findings
Abdominal Migraine in Children and Adolescents at a Single Tertiary Pediatric Gastroenterology Center: A Twelve-yea Experience on Clinical and Therapeutic Findings Open
Background: Abdominal migraine (AM) may be underdiagnosed and represent a substantial problem for children and their families. Aim: Evaluate the clinical characteristics and the response to prophylactic therapy with Cyproheptadine in child…
View article: The primary nutritional approach in pediatric celiac disease: a mini-review
The primary nutritional approach in pediatric celiac disease: a mini-review Open
Background: Celiac disease (CD) is chronic small bowel inflammation with villous atrophy, consequently, an immune-mediated disorder triggered by ingesting Gluten in wheat, barley, and rye in genetically susceptible individuals. Aims: Summa…
View article: The Primary Nutritional Approach in Pediatric Cystic Fibrosis: A Mini-Review
The Primary Nutritional Approach in Pediatric Cystic Fibrosis: A Mini-Review Open
In recent decades, diets for Pediatric Diseases have gained increasing acceptance, with disease-specific diets recommended in various international guidelines. This Mini-Review, a crucial resource for medical professionals, researchers, an…
View article: Transcutaneous Posterior Tibial Nerve Stimulation: An Adjuvant Treatment for Intractable Constipation in Children
Transcutaneous Posterior Tibial Nerve Stimulation: An Adjuvant Treatment for Intractable Constipation in Children Open
Background: Functional constipation can lead to painful defecations, fecal incontinence, and abdominal pain, significantly affecting a child’s quality of life. Treatment options include non-pharmacological and pharmacological approaches, b…
View article: Referee report. For: The psychosocial implication of childhood constipation on the children and family: A scoping review protocol. [version 1; peer review: 2 approved, 1 approved with reservations]
Referee report. For: The psychosocial implication of childhood constipation on the children and family: A scoping review protocol. [version 1; peer review: 2 approved, 1 approved with reservations] Open
View article: Pediatric Functional Constipation in Clinical Practice: The Continuous Search for the Light at the End of the Tunnel
Pediatric Functional Constipation in Clinical Practice: The Continuous Search for the Light at the End of the Tunnel Open
Functional constipation (FC) has a pooled world prevalence of 9.5%, a clear definition by Rome IV Criteria, and the NAPGHAN/ESPGHAN guidelines recommendation for management. With well-defined parameters, this commentary discusses the paths…
View article: Overweight/obesity Prevalence and Clinical Features in Children’s Functional Constipation: Descriptive Analysis in a Single Tertiary Center
Overweight/obesity Prevalence and Clinical Features in Children’s Functional Constipation: Descriptive Analysis in a Single Tertiary Center Open
Background and objectivesFunctional constipation (FC) and the overweight/obesity (O/O) association are controversial. This study aims to investigate the prevalence of O/O, demographics, and clinical characteristics between children with O/…
View article: Transcutaneous posterior tibial nerve stimulation: an adjuvant treatment for intractable constipation in children
Transcutaneous posterior tibial nerve stimulation: an adjuvant treatment for intractable constipation in children Open
BACKGROUND: Functional constipation can lead to painful defecations, fecal incontinence, and abdominal pain, significantly affecting a child's quality of life. Treatment options include non-pharmacological and pharmacological approach…
View article: Food Protein-Induced Proctocolitis: A Unique Subtype of Gastrointestinal Non-IgE-mediated Food Allergy
Food Protein-Induced Proctocolitis: A Unique Subtype of Gastrointestinal Non-IgE-mediated Food Allergy Open
Food allergy (FA) is an abnormal clinical reaction to proteins in which immunologically mediated mechanisms are implicated [1].Certainly, FA is a major global health problem, and its geographic distribution may be linked to genetic, enviro…
View article: The Groningen Defecation and Fecal Continence Questionnaire: the long way of an organized and methodical translation of Dutch to English, English to Chinese, and back to English and Dutch versions
The Groningen Defecation and Fecal Continence Questionnaire: the long way of an organized and methodical translation of Dutch to English, English to Chinese, and back to English and Dutch versions Open
View article: Hábitos intestinais em crianças e adolescentes com Síndrome de Down
Hábitos intestinais em crianças e adolescentes com Síndrome de Down Open
A Síndrome de Down é a anomalia cromossômica mais comum na população, com uma incidência estimada de 1 em 700 nascidos vivos, é caracterizada pela presença e expressão de três cópias de genes localizados no cromossomo 21. Crianças que apre…
View article: Review of: "Food Intolerance and Sensitivity Are Associated With Chronic Musculoskeletal Pain in a Self-Selected Community Population"
Review of: "Food Intolerance and Sensitivity Are Associated With Chronic Musculoskeletal Pain in a Self-Selected Community Population" Open
View article: Developing Ice Cream for Mucositis Management and Improving the Nutritional Support for Pediatric Cancer Patients
Developing Ice Cream for Mucositis Management and Improving the Nutritional Support for Pediatric Cancer Patients Open
Introduction: Mucositis is one of the main complications of cancer treatment, associated with several nutritional limitations and the ability to cause secondary infections. Cryotherapy is a low-cost treatment consistent with clinical pract…
View article: Children Dyspepsia Symptoms Questionnaire Discriminates Dyspeptic versus Non-Dyspeptic and Organic versus Functional Dyspepsia in Children and Adolescents with Chronic Abdominal Pain
Children Dyspepsia Symptoms Questionnaire Discriminates Dyspeptic versus Non-Dyspeptic and Organic versus Functional Dyspepsia in Children and Adolescents with Chronic Abdominal Pain Open
Background: Chronic Abdominal Pain (CAP) is common in children/adolescents, and Dyspepsia is a symptom complex. Their investigation represents a significant burden and a great deal regarding the initial work-up. Consequently, scoring based…
View article: Helicobacter pylori Chronic Gastritis in Children and Adolescents was not Associated with Anaemia
Helicobacter pylori Chronic Gastritis in Children and Adolescents was not Associated with Anaemia Open
Background: Helicobacter pylori (H. pylori) colonizes the gastric mucosa, leading to chronic inflammation. Epidemiological studies have demonstrated that H. pylori infection is high in areas with a high prevalence of anaemia. Consequently,…
View article: Labeling food allergens in the packaged food pyramid groups in Brazil: analysis of descriptions, ambiguities, and risks
Labeling food allergens in the packaged food pyramid groups in Brazil: analysis of descriptions, ambiguities, and risks Open
Objective: The aim of this study was to evaluate allergenic labeling components of packaged foods for “What is the quality of food labels?” and “What is the group of Brazilian Food Pyramid that ‘May contain’ is predominant?.” Methods: The …
View article: Rotulagem de alérgenos alimentares em alimentos embalados segundo grupos alimentares da pirâmide brasileira: análise da descrição, riscos e ambiguidades
Rotulagem de alérgenos alimentares em alimentos embalados segundo grupos alimentares da pirâmide brasileira: análise da descrição, riscos e ambiguidades Open
RESUMO Objetivo: Avaliar os componentes alergênicos da rotulagem de alimentos embalados e responder “Qual é a qualidade da rotulagem?” e “Qual é o grupo de alimentos em que a expressão ‘Pode conter’ é predominante?”. Métodos: Foram obtidas…
View article: Impaired Health-Related Quality of Life in Brazilian Children with Chronic Abdominal Pain: A Cross-Sectional Study
Impaired Health-Related Quality of Life in Brazilian Children with Chronic Abdominal Pain: A Cross-Sectional Study Open
This study revealed that there was a difference in impaired HRQOL between patients with ORGDs and FAPDs. Thus, considering the high prevalence of chronic abdominal pain in children, a well-founded treatment plan is necessary for a multidis…
View article: "Comparison of two self-report pain intensity scales in children and adolescents with chronic abdominal pain associated with Helicobacter pylori-dyspepsia and Irritable bowel syndrome"
"Comparison of two self-report pain intensity scales in children and adolescents with chronic abdominal pain associated with Helicobacter pylori-dyspepsia and Irritable bowel syndrome" Open
Purpose: To evaluate pain intensity and the agreement between the Visual Analogue Scale (VAS) and Faces Pain Scale (FAS) in children/adolescents with Chronic Abdominal Pain (CAP) both in Irritable Bowel Syndrome (IBS) and Helicobacter pylo…
View article: Pediatric Functional Constipation Questionnaire-Parent Report (PedFCQuest-PR): development and validation
Pediatric Functional Constipation Questionnaire-Parent Report (PedFCQuest-PR): development and validation Open
This study provides evidence that PedFCQuest-PR is a reliable instrument. The results showed a high degree of internal consistency and validity of the instrument for future applications.
View article: Clinical Features and Outcomes of Very‐Early‐Onset Inflammatory Bowel Disease in Brazilian Children
Clinical Features and Outcomes of Very‐Early‐Onset Inflammatory Bowel Disease in Brazilian Children Open
We report on 20 Brazilian children under 6 years of age with very‐early‐onset inflammatory bowel disease naive to treatment. The clinical, laboratory, and histopathologic findings at diagnosis and outcomes were reviewed: 13 had ulcerative …
View article: A protocol for an interventional study on the impact of transcutaneous parasacral nerve stimulation in children with functional constipation
A protocol for an interventional study on the impact of transcutaneous parasacral nerve stimulation in children with functional constipation Open
Introduction: Transcutaneous parasacral nerve stimulation (TPNS) via electrodes placed over the sacrum can activate afferent neuronal networks noninvasively, leading to sacral reflexes that may improve colonic motility. Thus, TPNS can be c…
View article: Transcutaneous posterior tibial nerve stimulation in children and adolescents with functional constipation
Transcutaneous posterior tibial nerve stimulation in children and adolescents with functional constipation Open
Introduction: A vast majority of children with functional constipation respond to the standard medical treatment. However, a subset of patients may present with an unsatisfactory response and only minor improvement of symptoms. Transcutane…
View article: Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study
Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study Open
View article: Avaliação da Eficácia da Dieta de Atkins Modificada em Crianças E Adolescentes com Epilepsia Refratária
Avaliação da Eficácia da Dieta de Atkins Modificada em Crianças E Adolescentes com Epilepsia Refratária Open
View article: Avaliação Nutricional de Crianças com Colestase Neonatal
Avaliação Nutricional de Crianças com Colestase Neonatal Open
View article: Ingestão Dietética de Pacientes com Fibrose Cística Atendidos em Ambulatório Terciário do Hospital das Clínicas de Botucatu
Ingestão Dietética de Pacientes com Fibrose Cística Atendidos em Ambulatório Terciário do Hospital das Clínicas de Botucatu Open
View article: Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study
Combinations of laxatives and green banana biomass on the treatment of functional constipation in children and adolescents: a randomized study Open
View article: Intake, bioavailability, and absorption of iron in infants aged 6 to 36 months: an observational study in a Brazilian Well Child Clinic
Intake, bioavailability, and absorption of iron in infants aged 6 to 36 months: an observational study in a Brazilian Well Child Clinic Open
Background Preventing the development of iron deficiency anemia during infancy requires the appropriate complementary foods with high energy, nutrient density, and adequate iron content, as well as high nutrient bioavailability. We aimed t…