Nilufer P. Seth
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View article: Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties
Nipocalimab, an immunoselective FcRn blocker that lowers IgG and has unique molecular properties Open
Nipocalimab is a human immunoglobulin G (IgG)1 monoclonal antibody that binds to the neonatal Fc receptor (FcRn) with high specificity and high affinity at both neutral (extracellular) and acidic (intracellular) pH, resulting in the reduct…
View article: Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation Open
The salt-inducible kinases (SIK) 1–3 are key regulators of pro- versus anti-inflammatory cytokine responses during innate immune activation. The lack of highly SIK-family or SIK isoform-selective inhibitors suitable for repeat, oral dosing…
View article: Data from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Data from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Open
The identification of new tumor-associated antigens (TAA) is critical for the development of effective immunotherapeutic strategies, particularly in diseases like B-cell acute lymphoblastic leukemia (B-ALL), where few target epitopes are k…
View article: Supplementary Tables 1-3 from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Supplementary Tables 1-3 from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Open
Supplementary Tables 1-3 from Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
View article: Data from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Data from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Open
The identification of new tumor-associated antigens (TAA) is critical for the development of effective immunotherapeutic strategies, particularly in diseases like B-cell acute lymphoblastic leukemia (B-ALL), where few target epitopes are k…
View article: Supplementary Tables 1-3 from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia
Supplementary Tables 1-3 from Gene Expression Profiling Identifies <i>BAX-δ</i> as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia Open
Supplementary Tables 1-3 from Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia