Nimalan Pathma‐Nathan
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View article: The emerging role of watch and wait in metastatic rectal cancer
The emerging role of watch and wait in metastatic rectal cancer Open
View article: The efficacy and safety of extended thromboprophylaxis after colorectal surgery: a systematic review and meta-analysis
The efficacy and safety of extended thromboprophylaxis after colorectal surgery: a systematic review and meta-analysis Open
Purpose To report (1) efficacy and (2) safety outcomes comparing extended thromboprophylaxis (ETP) with low molecular weight heparin (LMWH) and direct oral anticoagulants (DOAC) versus no ETP after colorectal surgery. Methods A systematic …
View article: Contemporary major abdominal surgical management of Crohn’s disease in the era of biologics and minimally invasive surgery
Contemporary major abdominal surgical management of Crohn’s disease in the era of biologics and minimally invasive surgery Open
View article: Colo-cutaneous fistula: an unusual complication after hemilaminectomy and microdiscectomy
Colo-cutaneous fistula: an unusual complication after hemilaminectomy and microdiscectomy Open
Although the current literature points to surgical complication as the most common cause of entero-cutaneous fistulae, the formation of a colo-cutaneous fistula following a microdiscectomy is an unusual complication. Derivation of iatrogen…
View article: 8770 Highly Multiplexed Mapping of the Ductal Carcinoma In Situ Ecosystem to Predict Disease Outcome
8770 Highly Multiplexed Mapping of the Ductal Carcinoma In Situ Ecosystem to Predict Disease Outcome Open
Disclosure: G.M. Wilson: None. T.B. Doan: None. B.J. Guild: None. N. Pathmanathan: None. J.D. Graham: None. Mammographic screening programs have resulted in remarkable improvements in breast cancer survival due to early-stage detection. Ho…
View article: Unresolved debate on surgery for deep infiltrating endometriosis of the rectum: bowel resection or a more conservative approach?
Unresolved debate on surgery for deep infiltrating endometriosis of the rectum: bowel resection or a more conservative approach? Open
Deep infiltrating endometriosis (DIE) of the bowel, defined by infiltration of endometriosis into the muscularis propria, or as a lesion invading the bowel wall >5 mm depth, occurs in 5.2%–12% of women with endometriosis.1, 2 The rectum an…
View article: Results of selective decontamination with oral neomycin and metronidazole for major colorectal surgery in Australia: A cohort study
Results of selective decontamination with oral neomycin and metronidazole for major colorectal surgery in Australia: A cohort study Open
Objective: The role of selective decontamination with oral antibiotics (OABs) and mechanical bowel preparation (MBP) prior to elective colorectal surgery is still widely debated. The objective of this study was to compare the outcomes of s…
View article: Rare case of strangulated primary acquired perineal hernia causing small bowel obstruction requiring emergency operative repair
Rare case of strangulated primary acquired perineal hernia causing small bowel obstruction requiring emergency operative repair Open
Primary acquired perineal hernia is rare with only 100 reported cases in the literature. Emergency presentations of intestinal obstruction secondary to perineal hernia are very rare and to-date, there are only eight cases reported in the l…
View article: The appendix: An unexpected band obstruction
The appendix: An unexpected band obstruction Open
Introduction: Small bowel obstruction (SBO) is common surgical pathology, most commonly secondary to adhesions. This case presents a novel cause of small bowel obstruction. Case Report: We present a case of an elderly female who presented …
View article: Endoscopic and trans-anal local excision vs. radical resection in the treatment of early rectal cancer: a systematic review and network meta-analysis
Endoscopic and trans-anal local excision vs. radical resection in the treatment of early rectal cancer: a systematic review and network meta-analysis Open
Purpose The management of early-stage rectal cancer in clinical practice is controversial. The aim of this network meta-analysis was to compare oncological and postoperative outcomes for T1T2N0M0 rectal cancers managed with local excision …
View article: C-Reactive Protein as a Predictive Marker for Anastomotic Leak Following Restorative Colorectal Surgery in an Enhanced Recovery After Surgery Program
C-Reactive Protein as a Predictive Marker for Anastomotic Leak Following Restorative Colorectal Surgery in an Enhanced Recovery After Surgery Program Open
View article: Is preoperative hypoalbuminemia or hypoproteinemia a reliable marker for anastomotic leakage risk in patients undergoing elective colorectal surgery in an enhanced recovery after surgery (ERAS) program?
Is preoperative hypoalbuminemia or hypoproteinemia a reliable marker for anastomotic leakage risk in patients undergoing elective colorectal surgery in an enhanced recovery after surgery (ERAS) program? Open
Purpose Preoperative hypoalbuminemia has traditionally been used as a marker of nutritional status and is considered a significant risk factor for anastomotic leak (AL). Methods The Westmead Enhanced Recovery After Surgery (WERAS) prospect…
View article: A rare case of ruptured appendiceal diverticulitis: A significant surgical pathology
A rare case of ruptured appendiceal diverticulitis: A significant surgical pathology Open
View article: Is preoperative hypoalbuminaemia or hypoproteinaemia a reliable marker for anastomotic leakage risk in patients undergoing elective colorectal surgery in an Enhanced Recovery after Surgery (ERAS) program?
Is preoperative hypoalbuminaemia or hypoproteinaemia a reliable marker for anastomotic leakage risk in patients undergoing elective colorectal surgery in an Enhanced Recovery after Surgery (ERAS) program? Open
Purpose: Preoperative hypoalbuminaemia has traditionally been used as a marker of nutritional status and is considered a significant risk factor for anastomotic leak (AL). Methods: The Westmead Enhanced Recovery After Surgery (WERAS) prosp…
View article: Measurement that matters: A systematic review and modified Delphi of multidisciplinary colorectal cancer quality indicators
Measurement that matters: A systematic review and modified Delphi of multidisciplinary colorectal cancer quality indicators Open
Aim To develop a priority set of quality indicators (QIs) for use by colorectal cancer (CRC) multidisciplinary teams (MDTs). Methods The review search strategy was executed in four databases from 2009–August 2019. Two reviewers screened ab…
View article: An unusual case of colonic duplication cyst in an adult with dysplasia
An unusual case of colonic duplication cyst in an adult with dysplasia Open
Duplication cysts are rare benign congenital malformations typically identified in children by the age of 2 years. We report a rare case of colonic duplication cyst with dysplasia in an adult. A 32-year-old male was diagnosed with non-spec…
View article: Robotic-assisted versus laparoscopic rectal surgery in obese and morbidly obese patients: ACS-NSQIP analysis
Robotic-assisted versus laparoscopic rectal surgery in obese and morbidly obese patients: ACS-NSQIP analysis Open
View article: An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission
An in situ analysis pipeline for initial host-pathogen interactions reveals signatures of human colorectal HIV transmission Open
The initial immune response to HIV determines transmission. However, due to technical limitations we still do not have a comparative map of early mucosal transmission events. By combining RNAscope, cyclic immunofluorescence, and image anal…
View article: 3D mesenteric angiogram-based assessment of Arc of Riolan crossing the inferior mesenteric vein: important considerations in high ligation during splenic flexure takedown in anterior resection
3D mesenteric angiogram-based assessment of Arc of Riolan crossing the inferior mesenteric vein: important considerations in high ligation during splenic flexure takedown in anterior resection Open
Background Recent studies have described the finding of the Arc of Riolan (AoR) crossing the inferior mesenteric vein (IMV) seen during high ligation of IMV while performing minimally invasive colectomies. However, the AoR usually has a me…
View article: An <i>in situ</i> quantitative map of initial human colorectal HIV transmission
An <i>in situ</i> quantitative map of initial human colorectal HIV transmission Open
The initial immune response to HIV is critical in determining transmission. However, due to technical limitations we still do not have a comparative map of early mucosal transmission events. We combined RNAscope, cyclic-immunofluorescence …
View article: Attitudes towards Enhanced Recovery after Surgery (ERAS) interventions in colorectal surgery: nationwide survey of Australia and New Zealand colorectal surgeons
Attitudes towards Enhanced Recovery after Surgery (ERAS) interventions in colorectal surgery: nationwide survey of Australia and New Zealand colorectal surgeons Open
Background Whilst Enhanced Recovery after Surgery (ERAS) has been widely accepted in the international colorectal surgery community, there remains significant variations in ERAS programme implementations, compliance rates and best practice…
View article: An <i>in situ</i> Quantitative Map of Initial Human Colorectal HIV Transmission
An <i>in situ</i> Quantitative Map of Initial Human Colorectal HIV Transmission Open
View article: Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn’s Disease
Neutrophil Extracellular Trap Density Increases With Increasing Histopathological Severity of Crohn’s Disease Open
Background Intestinal neutrophil recruitment is a characteristic feature of the earliest stages of inflammatory bowel disease (IBD). Neutrophil elastase (NE) and myeloperoxidase (MPO) mediate the formation of neutrophil extracellular traps…
View article: Can adjuvant pelvic radiation therapy after local excision or polypectomy for T1 and T2 rectal cancer offer an alternative option to radical surgery?
Can adjuvant pelvic radiation therapy after local excision or polypectomy for T1 and T2 rectal cancer offer an alternative option to radical surgery? Open
View article: Transanal minimally invasive surgery to rescue anastomosis following leak after low anterior resection: A case report
Transanal minimally invasive surgery to rescue anastomosis following leak after low anterior resection: A case report Open
Restorative low anterior resection (LAR) for rectal cancer carries a significant risk of anastomotic leak: One of the most feared complications in colorectal surgery. Operative management may include takedown of the anastomosis and end col…
View article: Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue
Optimal Isolation Protocols for Examining and Interrogating Mononuclear Phagocytes From Human Intestinal Tissue Open
The human intestine contains numerous mononuclear phagocytes (MNP), including subsets of conventional dendritic cells (cDC), macrophages (Mf) and monocytes, each playing their own unique role within the intestinal immune system and homeost…
View article: The impact of variations in care and complications within a colorectal Enhanced Recovery After Surgery program on length of stay
The impact of variations in care and complications within a colorectal Enhanced Recovery After Surgery program on length of stay Open
Purpose: Enhanced Recovery After Surgery (ERAS) has become standard of care in colorectal surgery. However, there is not a universally accepted colorectal ERAS protocol and significant variations in care exist between institutions. The aim…
View article: Outcomes of young patients diagnosed with locally advanced rectal cancer
Outcomes of young patients diagnosed with locally advanced rectal cancer Open
Patients under 50 years with LARC are more likely to have MSI tumours with a more aggressive disease course and poorer RFS, PFS and OS. Initiatives to improve early detection of these patients may improve outcomes. Further research is nece…
View article: Understanding the role of mechanical bowel preparation and oral antibiotics prior to elective colorectal surgery
Understanding the role of mechanical bowel preparation and oral antibiotics prior to elective colorectal surgery Open
Over the past four decades, there has been significant debate as to whether mechanical bowel preparation (MBP) and oral antibiotics (OAB) should be prescribed preoperatively prior to elective colorectal surgery. With the widespread impleme…
View article: Understanding the role of mechanical bowel preparation and oral antibiotics prior to elective colorectal surgery
Understanding the role of mechanical bowel preparation and oral antibiotics prior to elective colorectal surgery Open