Naseem Salahuddin
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View article: Ropeginterferon alfa-2b <i>vs</i> standard therapy in polycythemia vera: A meta-analysis of efficacy and safety outcomes
Ropeginterferon alfa-2b <i>vs</i> standard therapy in polycythemia vera: A meta-analysis of efficacy and safety outcomes Open
BACKGROUND Polycythemia vera (PV) is a myeloproliferative neoplasm characterized by excessive blood cell production, which increases the risk of thrombosis. Ropeginterferon alfa-2b (RI) offers potential advantages over standard therapy (ST…
View article: Towards Rabies Elimination in Pakistan: Barriers, Facilitators, and the Role of One Health
Towards Rabies Elimination in Pakistan: Barriers, Facilitators, and the Role of One Health Open
Background Rabies is a neglected zoonotic disease with an estimated 59,000 deaths annually, disproportionately affecting low- and middle-income countries. Pakistan remains a high-burden setting due to weak surveillance, poor intersectoral …
View article: A rabid cow bites the hand that feeds it
A rabid cow bites the hand that feeds it Open
View article: Corrigendum to “How a private organization in Pakistan initiated One Health Project to eliminate rabies” [IJID One Health 1 (2023) 100011]
Corrigendum to “How a private organization in Pakistan initiated One Health Project to eliminate rabies” [IJID One Health 1 (2023) 100011] Open
View article: Dermatoglyphics: The Future of Screening Type 2 Diabetes Mellitus?
Dermatoglyphics: The Future of Screening Type 2 Diabetes Mellitus? Open
BACKGROUND: Dermatoglyphics is a very old technique utilized for identity and distinguishing purposes, as it is firmly related to genetics. Researchers are attempting to utilize fingerprints to diagnose various diseases. This study was aim…
View article: Dermatoglyphics: The Future of Screening Type 2 Diabetes Mellitus?
Dermatoglyphics: The Future of Screening Type 2 Diabetes Mellitus? Open
BACKGROUND: Dermatoglyphics is a very old technique utilized for identity and distinguishing purposes, as it is firmly related to genetics. Researchers are attempting to utilize fingerprints to diagnose various diseases. This study was aim…
View article: Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis
Oral Regimens for Rifampin-Resistant, Fluoroquinolone-Susceptible Tuberculosis Open
Consistent results across all the analyses support the noninferior efficacy of three all-oral shortened regimens for the treatment of rifampin-resistant tuberculosis. (Funded by Unitaid and others; endTB ClinicalTrials.gov number, NCT02754…
View article: Rabies Virus RNA Detection in Wounds of Dog-Bite Victims: a Prospective Observational Cohort Study for Rapid Surveillance in Endemic Regions
Rabies Virus RNA Detection in Wounds of Dog-Bite Victims: a Prospective Observational Cohort Study for Rapid Surveillance in Endemic Regions Open
View article: Bedaquiline, Delamanid, Linezolid and Clofazimine for the Treatment of Rifampicin- and Fluoroquinolone-Resistant Tuberculosis (endTB-Q): A Phase 3, Open-Label, Multicentre, Randomised, Controlled, Stratified, Non-Inferiority Trial
Bedaquiline, Delamanid, Linezolid and Clofazimine for the Treatment of Rifampicin- and Fluoroquinolone-Resistant Tuberculosis (endTB-Q): A Phase 3, Open-Label, Multicentre, Randomised, Controlled, Stratified, Non-Inferiority Trial Open
View article: GAVI investment should accelerate Rabies “Zero by 30” aspiration
GAVI investment should accelerate Rabies “Zero by 30” aspiration Open
View article: Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis
Sputum culture reversion in longer treatments with bedaquiline, delamanid, and repurposed drugs for drug-resistant tuberculosis Open
View article: Nine-month, all-oral regimens for rifampin-resistant tuberculosis
Nine-month, all-oral regimens for rifampin-resistant tuberculosis Open
Background After a history of poor treatments for rifampin-resistant tuberculosis (RR-TB), recent advances have resulted in shorter, more effective treatments. However, they are not available to everyone and have shortcomings, requiring ad…
View article: Frequency of cryptococcal antigenemia in hiv treatment naïve patients with CD4 count below 200/ml
Frequency of cryptococcal antigenemia in hiv treatment naïve patients with CD4 count below 200/ml Open
Background: Cryptococcosis is a dangerous opportunistic fungal infection that poses a significant threat to individuals with advanced HIV/AIDS and compromised cellular immunity. The objective was to determine the frequency of asymptomatic …
View article: Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial
Evaluating newly approved drugs in combination regimens for multidrug-resistant tuberculosis with fluoroquinolone resistance (endTB-Q): study protocol for a multi-country randomized controlled trial Open
View article: How a private organization in Pakistan initiated One Health Project to eliminate rabies
How a private organization in Pakistan initiated One Health Project to eliminate rabies Open
In response to the escalating dog-bite incidents in Pakistan, the Indus Hospital Research Center (IHRC) introduced a pilot program of One Health to raise awareness about dog-related rabies in a fishing village in Karachi, and to vaccinate …
View article: World Rabies Day 2023 – Is an end to human rabies deaths in sight?
World Rabies Day 2023 – Is an end to human rabies deaths in sight? Open
View article: High prevalence of multidrug-resistant TB among household contacts in a high burden setting
High prevalence of multidrug-resistant TB among household contacts in a high burden setting Open
View article: Mass Dog Vaccination and Animal Birth Control: A One Health Pilot Project in Karachi, Pakistan
Mass Dog Vaccination and Animal Birth Control: A One Health Pilot Project in Karachi, Pakistan Open
The Sindh province in Southern Pakistan reports staggering numbers of dog bites. Not only to treat but to prevent, dog-bite casualties, in January 2018, the Indus Hospital launched a proof of concept of One Health. The pilot project ‘Rabie…
View article: Comparative effectiveness of adding delamanid to a multidrug-resistant tuberculosis regimen comprised of three drugs likely to be effective
Comparative effectiveness of adding delamanid to a multidrug-resistant tuberculosis regimen comprised of three drugs likely to be effective Open
Clarity about the role of delamanid in longer regimens for multidrug-resistant TB is needed after discordant Phase IIb and Phase III randomized controlled trial results. The Phase IIb trial found that the addition of delamanid to a backgro…
View article: Analysis of human rabies deaths reported at two hospitals in Karachi, Pakistan: a call to save lives by reforming rabies prevention facilities
Analysis of human rabies deaths reported at two hospitals in Karachi, Pakistan: a call to save lives by reforming rabies prevention facilities Open
Background Rabies is endemic in low- and middle-income countries. It is caused mainly by the bite of a rabid dog and is fatal if not treated effectively and in a timely manner with quality post-exposure prophylaxis. Despite a profusion of …
View article: Concordance of three approaches for operationalizing outcome definitions for multidrug-resistant TB
Concordance of three approaches for operationalizing outcome definitions for multidrug-resistant TB Open
BACKGROUND: The WHO provides standardized outcome definitions for rifampicin-resistant (RR) and multidrug-resistant (MDR) TB. However, operationalizing these definitions can be challenging in some clinical settings, and incorrect classific…
View article: Drug-Resistant Tuberculosis Treatment Outcomes among Children and Adolescents in Karachi, Pakistan
Drug-Resistant Tuberculosis Treatment Outcomes among Children and Adolescents in Karachi, Pakistan Open
Background: Significant data gaps exist for children and adolescents with drug-resistant (DR) TB, particularly from high TB incidence settings. This report provides a descriptive analysis of programmatic outcomes among children and adolesc…
View article: A call to accelerate an end to human rabies deaths
A call to accelerate an end to human rabies deaths Open
View article: Characteristics and Outcomes of Community Acquired Versus Hospital Acquired Sepsis at A Tertiary Care Hospital, Karachi
Characteristics and Outcomes of Community Acquired Versus Hospital Acquired Sepsis at A Tertiary Care Hospital, Karachi Open
Objective: The study compared the demographics, clinical characteristics and site of infection leading to community acquired and hospital acquired sepsis. Secondly, the study further compared the distribution of the isolated organisms and …
View article: WHO Point Prevalence Survey to Describe the Use of Antimicrobials at a Tertiary Care Center in Pakistan: A Situation Analysis for Establishing an Antimicrobial Stewardship Program
WHO Point Prevalence Survey to Describe the Use of Antimicrobials at a Tertiary Care Center in Pakistan: A Situation Analysis for Establishing an Antimicrobial Stewardship Program Open
Antimicrobial stewardship is a systematic approach for promoting and monitoring responsible antimicrobial use globally. We conducted a prospective point prevalence survey of antimicrobial utilization among hospitalized adult patients durin…
View article: Rabies mortality
Rabies mortality Open
This data describes the Rabies deaths in Pakistan
View article: Re-evaluating the merits of decentralization as a core strategy for effective delivery of drug-resistant tuberculosis care in Pakistan
Re-evaluating the merits of decentralization as a core strategy for effective delivery of drug-resistant tuberculosis care in Pakistan Open
Decentralized, person-centred models of care delivery for drug-resistant tuberculosis (DR-TB) continue to be under-resourced in high-burden TB countries. The implementation of such models—made increasingly urgent by the COVID-19 pandemic—a…
View article: Clinical, Socio-Demographic Characteristics and Gender Disparity in Patients with Tuberculosis Infection in Pakistan
Clinical, Socio-Demographic Characteristics and Gender Disparity in Patients with Tuberculosis Infection in Pakistan Open
Objectives: To assess the clinical, environmental, and socio-demographic characteristics leading to gender disparity in tuberculosis in Pakistan.
Study Design: Prospective Comparative study.
Study Setting and Duration: The Indus Hospital…
View article: Safety and Effectiveness Outcomes From a 14-Country Cohort of Patients With Multi-Drug Resistant Tuberculosis Treated Concomitantly With Bedaquiline, Delamanid, and Other Second-Line Drugs
Safety and Effectiveness Outcomes From a 14-Country Cohort of Patients With Multi-Drug Resistant Tuberculosis Treated Concomitantly With Bedaquiline, Delamanid, and Other Second-Line Drugs Open
Background Concomitant use of bedaquiline (Bdq) and delamanid (Dlm) for multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) has raised concerns about a potentially poor risk-benefit ratio. Yet this combination is an important alternat…
View article: Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial
Final efficacy analysis, interim safety analysis, and immunogenicity of a single dose of recombinant novel coronavirus vaccine (adenovirus type 5 vector) in adults 18 years and older: an international, multicentre, randomised, double-blinded, placebo-controlled phase 3 trial Open