Explanipedia

Exploring ethnic differences in the perioperative course of thoracic aortopathy Open

Nora Bacour, Aytug U. Tirpan, Nimrat Grewal · 2025

Background In patients with thoracic aortopathy post-operative recovery can be complicated by a lack of consistent, clear communication and guidance. Despite the growing recognition of these challenges, the specific needs of patients under…

Aortic wall lamellar structure in phylogeny and in humans: insights from bicuspid and tricuspid aortic valve morphology Open

Nora Bacour, Mohammad A. Zafar, Nicole Kargin, Bulat Zinganshin, Robert E. Poelmann , et al. · 2025

The number of elastic lamellae in the aortic wall is influenced by both age and valve morphology. BAV patients had less lamellae than TAV patients, which could contribute to the disparity in clinical outcomes. In older adults, age-related …

Nationwide survey of Indian cardiac surgeons on the management of acute type A aortic dissection Open

Mohammed Idhrees, Nimrat Grewal, Mohammed Ayyub, Jasima Nilofer, Bashi Velayudhan · 2025

Comparison of cardiovascular risk profiles of patients with type A aortic dissection and thoracic aortic aneurysm: a retrospective multicentre study Open

Aytug U. Tirpan, Onur B. Dolmaci, Evert K. Jansen, Jos W. R. Twisk, Robert J.M. Klautz , et al. · 2025

Objective A thoracic aortic aneurysm (TAA) is often considered a precursor to an acute type A aortic dissection (ATAAD), a life-threatening condition requiring immediate surgical intervention. While both conditions share histopathological …

Bridging Barriers: Engaging Ethnic Minorities in Cardiovascular Research Open

Nora Bacour, Simran Grewal, M.C. Ploem, Jeanine Suurmond, Robert J.M. Klautz , et al. · 2025

Background/Objectives: We address the ongoing under-representation of ethnic minority groups in cardiovascular research in this opinion paper—a challenge that limits both scientific validity and equitable healthcare outcomes. We aim to out…

Effect of Bicuspid or Tricuspid Aortic Valve on Preoperative Coagulation in Patients Scheduled for Thoracic Aortic Surgery Open

Maite M.T. van Haeren, Caitlin Bozic, Susanne Eberl, Markus W. Hollmann, Jennifer S. Breel , et al. · 2025

Patients with a BAV have similar preoperative coagulation profiles and postoperative outcomes as TAV patients, based on ROTEM and conventional coagulation tests. While TAV patients required more RBC and platelet transfusions, this is likel…

Geranylgeranylacetone as Prevention for Postoperative Atrial Fibrillation (GENIALITY) Open

Kennedy S. Ramos, Soufiane Nassiri, Leonoor F.J. Wijdeveld, Reinier L van der Palen, Myrthe F. Kuipers , et al. · 2025

Brief Review: Racial Disparities in the Presentation and Outcomes of Patients with Thoracic Aortic Aneurysms Open

Nora Bacour, Rutger T. Theijsse, Simran Grewal, Robert J.M. Klautz, Nimrat Grewal · 2025

(1) Background: Thoracic aortic aneurysms (TAAs) pose critical health risks and are often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasiz…

Beyond Survival: Assessing Quality of Life, Activity Level, and Ethnic Diversity in Aortic Dissection Survivors Open

Nora Bacour, Olivia van Erp, Simran Grewal, Aytug U. Tirpan, Susanne Eberl , et al. · 2025

Background: An acute aortic dissection (AAD) is a highly lethal condition that demands immediate medical intervention. Survivors often face significant long-term challenges. While immediate survival remains a critical focus in acute care s…

From Survival to Recovery: Understanding the Life Impact of an Acute Aortic Dissection Through Activity, Sleep, and Quality of Life Open

Nora Bacour, Simran Grewal, Rutger T. Theijsse, Robert J.M. Klautz, Nimrat Grewal · 2025

Background/Objectives: An acute aortic dissection (AAD) is a cardiovascular emergency with high mortality rates if left untreated. Survival has increased due to improvements in diagnosis and therapy. However, during their recovery, survivo…

Aortic root replacement for bicuspid aortic valve dysfunction does not impair survival rates Open

Onur B. Dolmaci, Ninieck E van Maasakker, Robert E. Poelmann, Robert J.M. Klautz, Nimrat Grewal · 2024

This study shows that performing an aortic root replacement with a composite valve-graft conduit in bicuspid aortic valve patients does not impair the survival outcomes. In the light of preventing potential future aortic complications with…

The TRAIN Health Awareness Clinical Trial: Baseline Findings and Cardiovascular Risk Management in Aortic Dissection Patients Open

Nora Bacour, Simran Grewal, Aytug U. Tirpan, Rutger T. Theijse, Olivia van Erp , et al. · 2024

Acute Type A aortic dissection (ATAAD) is a life-threatening condition requiring timely surgical intervention. Despite successful surgery, postoperative outcomes are frequently suboptimal due to the high frequency of cardiovascular risk fa…

Racial and Ethnic Disparities in the Presentation and Outcome of Patients with Thoracic Aortic Aneurysms Open

Nora Bacour, Rutger T. Theijse, Robert J Klautz, Nimrat Grewal · 2024

Thoracic aortic aneurysms (TAAs) pose critical health risks, often asymptomatic until a rupture or dissection occurs. Guidelines recommend surgical repair based on specific aortic diameters and risk factors, emphasizing the importance of e…

Racial and Ethnic Disparities in the Presentation and Outcome of Patients with Thoracic Aortic Aneurysms Open

Nora Bacour, Rutger T. Theijse, Nimrat Grewal, Robert J Klautz · 2024

Background/Objectives: Thoracic aortic aneurysms (TAAs) pose critical health risks, often asymptomatic until a rupture or dissection occurs. Current guidelines recommend surgical repair based on specific aortic diameters and risk factors, …

Exploring the impact of sleep on emotional and physical well-being in professional cricketers: a cohort study over an in-season training period Open

Simran Grewal, Rutger T. Theijse, G. L. Dunlop, Derek F.P. van Deurzen, Michel P.J. van den Bekerom , et al. · 2024

Background Professional athletes navigate a multitude of unique challenges associated to sport-specific factors (e.g., training, travel and competition) and non-sport factors (e.g., performance pressure, stress and anxiety) that can interf…

Practical Considerations of Remote Care in Thoracic Aortopathy in India Open

Nimrat Grewal, Mohammed Idhrees, Bashi Velayudhan, Robert J Klautz, Simran Grewal · 2024

Background: Thoracic aortopathy includes conditions like aortic aneurysms and dissections, posing significant management challenges. In India, care delivery is complicated by geographic vastness, financial constraints, and healthcare resou…

Practical Considerations of Remote Care in Thoracic Aortopathy in India Open

Nimrat Grewal, Mohammed Idhrees, Bashi Velayudhan, Robert J Klautz, Simran Grewal · 2024

Thoracic aortopathy encompasses a spectrum of conditions affecting the aorta, ranging from aneurysms to dissections, posing significant challenges in management and care. In recent years, remote care, facilitated by telemedicine and digita…

Sex Differences in the Histopathology of Acute Type A Aortic Dissections Open

Nimrat Grewal, Onur B. Dolmaci, Robert J.M. Klautz, Robert E. Poelmann · 2024

Background Although sex-related differences in cardiovascular surgery outcomes have increasingly garnered attention in the past decades, knowledge about sex disparities in the pathophysiology of acute type A aortic dissections (ATAADs) rem…

The Prevalence of Coronary Artery Disease in Bicuspid Aortic Valve Patients: An Overview of the Literature Open

Onur B. Dolmaci, Tijmen L. Hilhorst, Arjan Malekzadeh, Bart Mertens, Robert J.M. Klautz , et al. · 2023

The prevalence of coronary artery disease (CAD) in bicuspid aortic valve (BAV) patients is a debatable topic. Several studies have indicated that BAV patients have a lower prevalence of CAD compared with patients with a tricuspid aortic va…

Evidence Accumulates: Patients with Ascending Aneurysms Are Strongly Protected from Atherosclerotic Disease Open

Christina Waldron, Mohammad A. Zafar, Bulat A. Ziganshin, Gabe Weininger, Nimrat Grewal , et al. · 2023

Ascending thoracic aortic aneurysms may be fatal upon rupture or dissection and remain a leading cause of death in the developed world. Understanding the pathophysiology of the development of ascending thoracic aortic aneurysms may help re…

Thoracic aortic atherosclerosis in patients with a bicuspid aortic valve; a case–control study Open

Onur B. Dolmaci, Robert J.M. Klautz, Robert E. Poelmann, J. Lindeman, Ralf W. Sprengers , et al. · 2023

Intrinsic histological and morphological abnormalities of the pediatric thoracic aorta in bicuspid aortic valve patients are predictive for future aortopathy Open

Nimrat Grewal, Robert J.M. Klautz, Robert E. Poelmann · 2023

The main characteristics of a bicuspid ascending aortic wall are already present before adulthood, albeit not before birth. Considering the early manifestations of ascending aortic wall pathology in bicuspid aortic valve patients, the pedi…

Is the intimal thickness a key contributor to thoracic aortopathy? Open

Nimrat Grewal, Robert E. Poelmann · 2023

The role of transforming growth factor beta in bicuspid aortic valve aortopathy Open

Nimrat Grewal, Onur B. Dolmaci, Arthur Klautz, Juno Legué, Antoine H.G. Driessen , et al. · 2023

Adventitial adaptive immune cells are associated with ascending aortic dilatation in patients with a bicuspid aortic valve Open

Alexander H. J. Staal, Kimberley R.G. Cortenbach, Mark A.J. Gorris, Lieke L. van der Woude, Mangala Srinivas , et al. · 2023

Background Bicuspid aortic valve (BAV) is associated with ascending aorta aneurysms and dissections. Presently, genetic factors and pathological flow patterns are considered responsible for aneurysm formation in BAV while the exact role of…

Thoracic aortopathy in Marfan syndrome overlaps with mechanisms seen in bicuspid aortic valve disease Open

Nimrat Grewal, Onur B. Dolmaci, Evert Jansen, Robert J.M. Klautz, Antoine H.G. Driessen , et al. · 2023

Background Thoracic aortopathy is a serious complication which is more often seen in patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) than in individuals with a tricuspid aortic valve (TAV). The identific…

Commentary: Transforming growth factor serum concentrations in patients with proven non-syndromic aortopathy Open

Nimrat Grewal, Robert J.M. Klautz, Robert E. Poelmann · 2023

GENERAL COMMENTARY article Front. Cardiovasc. Med., 02 February 2023Sec. Heart Surgery Volume 10 - 2023 | https://doi.org/10.3389/fcvm.2023.1097201

Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy Open

Onur B. Dolmaci, Tugay Ayyildiz, Robert E. Poelmann, Antoine H.G. Driessen, David R. Koolbergen , et al. · 2023

Objective Patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) have a significantly increased risk to develop thoracic aortopathy. Both conditions share many pathophysiological mechanisms leading to aortic co…

Are acute type A aortic dissections atherosclerotic? Open

Nimrat Grewal, Onur B. Dolmaci, Evert Jansen, Robert J.M. Klautz, Antoine H.G. Driessen , et al. · 2023

Background Type A aortic dissections (TAAD) are devastating aortic complications. Patients with Marfan syndrome, a bicuspid aortic valve or a thoracic aortic aneurysm have an increased risk to develop a TAAD. These predisposing conditions …

Are Thoracic Aortic Aneurysm Patients at Increased Risk for Cardiovascular Diseases? Open

Onur B. Dolmaci, Sulayman el Mathari, Antoine H.G. Driessen, Robert J.M. Klautz, Robert E. Poelmann , et al. · 2022

Objectives: Abdominal aortic aneurysms are associated with a sharply increased cardiovascular risk. Cardiovascular risk management is therefore recommended in prevailing guidelines for abdominal aneurysm patients. It has been hypothesized …

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