Nimrod D. Rubinstein
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View article: Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression Open
While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that ur…
View article: Author response: Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression
Author response: Urocortin-3 neurons in the mouse perifornical area promote infant-directed neglect and aggression Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract While recent studies have uncovered dedica…
View article: The Tug1 lncRNA locus is essential for male fertility
The Tug1 lncRNA locus is essential for male fertility Open
Background Several long noncoding RNAs (lncRNAs) have been shown to function as components of molecular machines that play fundamental roles in biology. While the number of annotated lncRNAs in mammalian genomes has greatly expanded, study…
View article: Additional file 6 of The Tug1 lncRNA locus is essential for male fertility
Additional file 6 of The Tug1 lncRNA locus is essential for male fertility Open
Additional file 6: Table S2. Testes RNA-seq and Tug1rescue RNA-seq in testes.
View article: Additional file 9 of The Tug1 lncRNA locus is essential for male fertility
Additional file 9 of The Tug1 lncRNA locus is essential for male fertility Open
Additional file 9: Table S5. Allele-specific RNA-seq in testes, differentially expressed genes.
View article: Additional file 7 of The Tug1 lncRNA locus is essential for male fertility
Additional file 7 of The Tug1 lncRNA locus is essential for male fertility Open
Additional file 7: Table S3. Prostate, spleen, eyes, brain, heart, liver, and MEF RNA-seq.
View article: Additional file 8 of The Tug1 lncRNA locus is essential for male fertility
Additional file 8 of The Tug1 lncRNA locus is essential for male fertility Open
Additional file 8: Table S4. Allele-specific RNA-seq in testes, expression data.
View article: Additional file 5 of The Tug1 lncRNA locus is essential for male fertility
Additional file 5 of The Tug1 lncRNA locus is essential for male fertility Open
Additional file 5: Table S1. Tug1-/- and wild type sperm morphological defects.
View article: Corrigendum: Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging
Corrigendum: Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging Open
The authors would like to correct an omission in the Methods section of the above-mentioned article under the "CM collection by fluorescence-activated cell sorting (FACS)"
View article: Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging
Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging Open
Aging is a pleiotropic process affecting many aspects of mammalian physiology. Mammals are composed of distinct cell type identities and tissue environments, but the influence of these cell identities and environments on the trajectory of …
Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity Open
View article: Molecular and Circuit Architecture of Social Hierarchy
Molecular and Circuit Architecture of Social Hierarchy Open
SUMMARY Social hierarchy is a common organizational structure of animal groups, in which an individual’s social status generates an adaptive behavioral state that facilitates interactions with other group members. Although generally stable…
View article: The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata
The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata Open
View article: Urocortin-3 Neurons in the Mouse Perifornical Area Promote Infant-directed Neglect and Aggression
Urocortin-3 Neurons in the Mouse Perifornical Area Promote Infant-directed Neglect and Aggression Open
While recent studies have uncovered dedicated neural pathways mediating the positive control of parenting, the regulation of infant-directed aggression and how it relates to adult-adult aggression is poorly understood. Here we show that ur…
View article: The <i>Tug1</i> Locus is Essential for Male Fertility
The <i>Tug1</i> Locus is Essential for Male Fertility Open
Background Several long noncoding RNAs (lncRNAs) have been shown to function as central components of molecular machines that play fundamental roles in biology. While the number of annotated lncRNAs in mammalian genomes has greatly expande…
View article: eIF2B activator prevents neurological defects caused by a chronic integrated stress response
eIF2B activator prevents neurological defects caused by a chronic integrated stress response Open
The integrated stress response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange …
View article: Additional file 9: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata
Additional file 9: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata Open
Transcription factor family expansions and contractions. (XLSX 30 kb)
View article: Additional file 11: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata
Additional file 11: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata Open
Slow- and fast-evolving proteins. (ZIP 104 kb)
View article: Additional file 5: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata
Additional file 5: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata Open
Sexual reproduction and candidate genes. (ZIP 182 kb)
View article: Additional file 7: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata
Additional file 7: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata Open
Expanded and contracted families. (ZIP 220 kb)
View article: Additional file 6: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata
Additional file 6: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata Open
In vitro culture and gene expression. (ZIP 1530 kb)
View article: Additional file 8: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata
Additional file 8: of The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata Open
Signal transduction diversification. (ZIP 3420 kb)
View article: Author response: eIF2B activator prevents neurological defects caused by a chronic integrated stress response
Author response: eIF2B activator prevents neurological defects caused by a chronic integrated stress response Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The integrated stress respons…
View article: eIF2B activator prevents neurological defects caused by a chronic Integrated Stress Response
eIF2B activator prevents neurological defects caused by a chronic Integrated Stress Response Open
The Integrated Stress Response (ISR) attenuates the rate of protein synthesis while inducing expression of stress proteins in cells. Various insults activate kinases that phosphorylate the GTPase eIF2 leading to inhibition of its exchange …
View article: Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region
Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region Open
Mapping the brain, one neuron at a time Spatial transcriptomics can link molecularly described cell types to their anatomical positions and functional roles. Moffitt et al. used a combination of single-cell RNA-sequencing and MERFISH (mult…
View article: Transitions in paternal dominance regulate offspring growth and metabolic transcription
Transitions in paternal dominance regulate offspring growth and metabolic transcription Open
Parental effects are an important source of adaptive traits. By contrast, parental effects failing to regulate offspring phenotype to fit current conditions could be deleterious. Although adaptive parental responses to single cues have bee…
View article: New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain
New Perspectives on Genomic Imprinting, an Essential and Multifaceted Mode of Epigenetic Control in the Developing and Adult Brain Open
Mammalian evolution entailed multiple innovations in gene regulation, including the emergence of genomic imprinting, an epigenetic regulation leading to the preferential expression of a gene from its maternal or paternal allele. Genomic im…
View article: Regulation of alternative splicing at the single‐cell level
Regulation of alternative splicing at the single‐cell level Open
Alternative splicing is a key cellular mechanism for generating distinct isoforms, whose relative abundances regulate critical cellular processes. It is therefore essential that inclusion levels of alternative exons be tightly regulated. H…
View article: Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain Open
The maternal and paternal genomes play different roles in mammalian brains as a result of genomic imprinting, an epigenetic regulation leading to differential expression of the parental alleles of some genes. Here we investigate genomic im…
View article: Author response: Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
Author response: Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The maternal and paternal gen…