Nina E. de Groot
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View article: Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome
Identifying colorectal cancer-specific vulnerabilities in the Wnt-driven long non-coding transcriptome Open
Background Aberrant Wnt pathway activation is a key driver of colorectal cancer (CRC) and is essential to sustain tumour growth and progression. Although the downstream protein-coding target genes of the Wnt cascade are well known, the lon…
View article: The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut
The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut Open
The rapid renewal of the epithelial gut lining is fuelled by stem cells that reside at the base of intestinal crypts. The signal transduction pathways and morphogens that regulate intestinal stem cell self-renewal and differentiation have …
View article: The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts
The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts Open
The cancer xenograft model in which human cancer cells are implanted in a mouse is one of the most used preclinical models to test the efficacy of novel cancer drugs. However, the model is imperfect; animal models are ethically burdened, a…
View article: Additional file 2 of Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development
Additional file 2 of Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development Open
Additional file 2. Location signatures are downregulated upon Wnt activation. Genes depicted in Fig. 2A are provided in a table format with compiled log2 fold changes (l2FC) (n = 3) for each location separately. The comparison of the wt sa…
View article: Additional file 5 of Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development
Additional file 5 of Intestinal region-specific Wnt signalling profiles reveal interrelation between cell identity and oncogenic pathway activity in cancer development Open
Additional file 5. Primers used in quantitative PCR.
View article: Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts
Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts Open
Significance Colorectal cancer (CRC) is a heterogeneous disease, with significant variation in genotype and phenotype within each individual tumor. This intratumor heterogeneity emerges during tumor development due to clonal evolution and …
View article: The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice
The RNA-binding protein Rbm38 is dispensable during pressure overload-induced cardiac remodeling in mice Open
The importance of tightly controlled alternative pre-mRNA splicing in the heart is emerging. The RNA binding protein Rbm24 has recently been identified as a pivotal cardiac splice factor, which governs sarcomerogenesis in the heart by cont…