Explanipedia

Endobronchial Valve Treatment Improves Regional Specific Ventilation in the Target Lung Open

Sharyn A. Roodenburg, Dirk‐Jan Slebos, Else A.M.D. ter Haar, Nina Eikelis, Kristopher Nilsen , et al. · 2025

Introduction: Previous studies yielded inconsistent results regarding whether bronchoscopic lung volume reduction using endobronchial valves (EBVs) improves pulmonary ventilation. The aim of this study was to evaluate changes in ventilatio…

Association between muscle sympathetic nerve activity and red blood cell distribution width in adults Open

Gavin Lambert, Carolina I. Sari, Nora E. Straznicky, John B. Dixon, Nina Eikelis , et al. · 2025

Measures obtained from the full blood count have been shown to vary around a set point, are stable over years, and provide an indication of disease risk and mortality. In this study, we examined the association between sympathetic nerve ac…

Increased plasma levels of erythropoietin after renal denervation in patients with resistant hypertension Open

Jianzhong Xu, Gianni Sesa‐Ashton, Nina Eikelis, Antony Walton, Élisabeth Lambert , et al. · 2025

Erythropoietin (Epo) plays a crucial role in the formation and maturation of erythrocytes and is produced primarily by peritubular cells in the renal cortex. Previous studies suggest that renal sympathetic nerve activity (RSNA) may influen…

More accessible functional lung imaging: non-contrast CT-ventilation demonstrates strong association and agreement with PET-ventilation Open

Hilary L. Byrne, Nina Eikelis, Jonathan Dusting, Andreas Fouras, Paul Keall , et al. · 2025

A longitudinal evaluation of localised chronic Pseudomonas aeruginosa infection in cystic fibrosis rat models Open

Nicole Reyne, Bernadette Boog, Patricia Cmielewski, Alexandra McCarron, Ronan Smith , et al. · 2025

Recurrent bacterial infections with Pseudomonas aeruginosa result in chronic airway inflammation, lung damage and eventual respiratory failure, and are the major cause of morbidity and mortality in people with cystic fibrosis (CF). Animal …

Functional Lung Imaging Identifies Peripheral Ventilation Changes in ꞵ‐ENaC Mice Open

Nicole Reyne, Ronan Smith, Patricia Cmielewski, Nina Eikelis, Kris Nilsen , et al. · 2025

Background and Objective β‐ENaC‐Tg mice serve as a relevant model of muco‐obstructive lung disease and diffuse‐type emphysema, with impaired mucociliary clearance, mucus obstruction, chronic airway inflammation, structural lung damage, and…

Efficacy and safety of a whole lung lavage program for artificial stone silicosis Open

Hayley Barnes, David Pilcher, Jennifer T. Coull, Jesselyn Sin, Eli Dabscheck , et al. · 2024

WLL for artificial stone silicosis is safe in an expert centre who has experience in performing WLL in this population, and there may be limited benefit in selected patients. Further research is required to select those who will derive the…

Assessment of respiratory mechanics and X-ray velocimetry functional imaging in two cystic fibrosis rat models Open

Nicole Reyne, Ronan Smith, Patricia Cmielewski, Nina Eikelis, Mark Lawrence , et al. · 2024

Investigating the relationship between early cardiovascular disease markers and loneliness in young adults Open

Shradha Vasan, Michelle H. Lim, Nina Eikelis, Élisabeth Lambert · 2024

Corrigendum: Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats Open

Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Elena K. Schneider‐Futschik , et al. · 2024

[This corrects the article DOI: 10.3389/fphar.2024.1362325.].

Effect of elexacaftor-tezacaftor-ivacaftor on nasal potential difference and lung function in Phe508del rats Open

Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, Ronan Smith, Elena K. Schneider‐Futschik , et al. · 2024

Introduction: Phe508del is the most common cystic fibrosis transmembrane conductance regulator (CFTR) gene variant that results in the recessive genetic disorder cystic fibrosis (CF). The recent development of highly effective CFTR modulat…

152 Cystic fibrosis rat models demonstrate altered respiratory mechanics and X-ray velocimetry parameters Open

Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, P. Pirakan, Nina Eikelis , et al. · 2023

165 Assessing CFTR function and lung mechanics in Phe508del rats treated with modulators Open

Nicole Reyne, Patricia Cmielewski, Alexandra McCarron, P. Pirakan, Nina Eikelis , et al. · 2023

Association of x-ray velocimetry (XV) ventilation analysis compared to spirometry Open

Jason P. Kirkness, Jonathan Dusting, Nina Eikelis, Piraveen Pirakalathanan, John J. DeMarco , et al. · 2023

Introduction X-ray Velocimetry (XV) ventilation analysis is a 4-dimensional imaging-based method for quantifying regional ventilation, aiding in the assessment of lung function. We examined the performance characteristics of XV ventilation…

Functional imaging for assessing regional lung ventilation in preclinical and clinical research Open

Dipan Karmali, Mudiaga Sowho, Sonali Bose, Jackson Pearce, Vickram Tejwani , et al. · 2023

Dynamic heterogeneity in lung ventilation is an important measure of pulmonary function and may be characteristic of early pulmonary disease. While standard indices like spirometry, body plethysmography, and blood gases have been utilized …

Evaluating the impact of loneliness and social isolation on health literacy and health-related factors in young adults Open

Shradha Vasan, Nina Eikelis, Michelle H. Lim, Élisabeth Lambert · 2023

Objectives In current study, we aim to extend previous research by investigating the unique impact of loneliness on health literacy and health-related factors of young adults, after controlling for social isolation, depressive symptomology…

Impact of loneliness on health‐related factors in Australia during the COVID ‐19 pandemic: A retrospective study Open

Shradha Vasan, Élisabeth Lambert, Nina Eikelis, Michelle H. Lim · 2022

COVID-19 pandemic and its associated social and physical distancing restrictions may have had a severe impact on health. In the present study, we investigate the changes in physical, social and mental health, as well as the health literacy…

Renal Deafferentation Prevents Progression of Hypertension and Changes to Sympathetic Reflexes in a Rabbit Model of Chronic Kidney Disease Open

Yusuke Sata, Sandra L. Burke, Nina Eikelis, Anna M.D. Watson, Cindy Gueguen , et al. · 2021

There is increasing evidence that renal denervation is effective in alleviating hypertension associated with elevation of renal sympathetic nerve activity (RSNA) in chronic kidney disease (CKD), but whether this is due to reduction in rena…

Renal, Cardiac, and Autonomic Effects of Catheter-Based Renal Denervation in Ovine Heart Failure Open

Lindsea C. Booth, R. Anethra U. de Silva, Roberto Albuquerque Pontes Filho, Song T. Yao, Sally G. Hood , et al. · 2021

A growing number of clinical studies suggest that in heart failure renal denervation (RDN) has beneficial effects on the autonomic control of the heart. There is also experimental evidence that surgical RDN improves sodium handling and cle…

Autonomic Nervous System Function in Anorexia Nervosa: A Systematic Review Open

Zoë Jenkins, Nina Eikelis, Andrea Phillipou, David Castle, Helen Wilding , et al. · 2021

Background: Autonomic nervous system (ANS) dysfunction has been suggested to contribute to the high prevalence of cardiovascular complications in individuals with anorexia nervosa (AN), yet has not been thoroughly investigated. The current…

Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting Open

Michael Nakai, Joshua Denham, Priscilla R. Prestes, Nina Eikelis, Élisabeth Lambert , et al. · 2021

Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in mala…

Investigation of the biology of adipocyte, brain and cardiac leptin and of the impact of leptin on the sympathetic nervous system Open

Nina Eikelis · 2021

This thesis was scanned from the print manuscript for digital preservation and is copyright the author. Researchers can access this thesis by asking their local university, institution or public library to make a request on their behalf. M…

Plasma Docosahexaenoic Acid and Eicosapentaenoic Acid Concentrations Are Positively Associated with Brown Adipose Tissue Activity in Humans Open

Angie S. Xiang, Corey Giles, Rebecca Loh, Melissa F. Formosa, Nina Eikelis , et al. · 2020

Brown adipose tissue (BAT) activation is a possible therapeutic strategy to increase energy expenditure and improve metabolic homeostasis in obesity. Recent studies have revealed novel interactions between BAT and circulating lipid species…

Contribution of the Renal Nerves to Hypertension in a Rabbit Model of Chronic Kidney Disease Open

Yusuke Sata, Sandra L. Burke, Cindy Gueguen, Kyungjoon Lim, Anna M.D. Watson , et al. · 2020

Overactivity of the sympathetic nervous system and high blood pressure are implicated in the development and progression of chronic kidney disease (CKD) and independently predict cardiovascular events in end-stage renal disease. To assess …

Empagliflozin modulates renal sympathetic and heart rate baroreflexes in a rabbit model of diabetes Open

Cindy Gueguen, Sandra L. Burke, Benjamin Barzel, Nina Eikelis, Anna M.D. Watson , et al. · 2020

As empagliflozin can restore diabetes-induced augmented sympathetic reflexes, this may be beneficial in diabetic patients. A similar action of the diuretic acetazolamide suggests that the mechanism may involve increased sodium and water ex…

Android Fat Deposition and Its Association With Cardiovascular Risk Factors in Overweight Young Males Open

Carolina I. Sari, Nina Eikelis, Geoffrey A. Head, Markus P. Schlaich, Peter J. Meikle , et al. · 2019

Objective: Excess adiposity increases the risk of type-2 diabetes and cardiovascular disease development. Beyond the simple level of adiposity, the pattern of fat distribution may influence these risks. We sought to examine if higher andro…

Obesity-Associated Organ Damage and Sympathetic Nervous Activity Open

Élisabeth Lambert, Murray Esler, Markus P. Schlaich, John B. Dixon, Nina Eikelis , et al. · 2019

Renal nerves contribute to hypertension in Schlager BPH/2J mice Open

Cindy Gueguen, Kristy L. Jackson, Francine Z. Marques, Nina Eikelis, Sarah Phillips , et al. · 2018

Renalase — a potential biomarker for risk of atrial fibrillation? Open

Markus P. Schlaich, Gavin Lambert, Nina Eikelis · 2018

Does modifying the timing of meal intake improve cardiovascular risk factors? Protocol of an Australian pilot intervention in night shift workers with abdominal obesity Open

Maxine P. Bonham, Gloria K. W. Leung, Rochelle Davis, Tracey L. Sletten, Chiara Murgia , et al. · 2018

Introduction Shift work is an independent risk factor for cardiovascular disease (CVD). Shift workers who are awake overnight and sleep during the day are misaligned with their body’s endogenous circadian rhythm. Eating at night contribute…

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