Nina M. van Sorge
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View article: Evolving pneumococcal epidemiology and vaccine impact in the Netherlands, 2004–2024: Carriage and invasive disease
Evolving pneumococcal epidemiology and vaccine impact in the Netherlands, 2004–2024: Carriage and invasive disease Open
This study shows stabilized pneumococcal carriage from 2018 to 2023 with low invasive disease potential for common serotypes, except for serotype 19A. However, rising IPD incidence from other non-vaccine serotypes highlights the need for h…
View article: Editor’s Choice Platform for identifying human glycan-specific antibodies against bacterial pathogens using synthetic glycan fragments
Editor’s Choice Platform for identifying human glycan-specific antibodies against bacterial pathogens using synthetic glycan fragments Open
Bacterial infections represent a substantial global health challenge, impacting both human and veterinary health. The ongoing evolution of antibiotic-resistant pathogens, coupled with limited new antibiotic discoveries, urges the need for …
View article: Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens
Isotype conversion of Staphylococcal-specific IgG into IgM broadens the reactivity to other bacterial pathogens Open
View article: Phage resistance impacts antibiotic susceptibility and virulence in <i>Staphylococcus aureus</i>
Phage resistance impacts antibiotic susceptibility and virulence in <i>Staphylococcus aureus</i> Open
As antibiotic resistance continues to rise worldwide, phage therapy offers a promising solution by harnessing viruses that infect and kill bacteria. However, phage-resistance may develop, compromising therapy. Phage-resistance has primaril…
View article: Staphylococcus aureus adaptation to vancomycin influences phage susceptibility
Staphylococcus aureus adaptation to vancomycin influences phage susceptibility Open
Phages are bacterial viruses considered as therapeutics for treatment of serious infections with antibiotic-resistant pathogens. In Staphylococcus aureus, resistance to cell wall targeting antibiotics is common in the methicillin resistant…
View article: Risk Factors for Severe Pediatric Invasive Group A Streptococcal Disease
Risk Factors for Severe Pediatric Invasive Group A Streptococcal Disease Open
Importance An increase in pediatric cases of invasive group A streptococcus (iGAS) disease was noted in the Netherlands starting in early 2022. GAS disease can range from mild to life-threatening invasive infections. Clinical and public he…
View article: Platform for Identifying Human Glycan-Specific Antibodies Against Bacterial Pathogens using Synthetic Glycan Fragments
Platform for Identifying Human Glycan-Specific Antibodies Against Bacterial Pathogens using Synthetic Glycan Fragments Open
Bacterial infections represent a substantial global health challenge, impacting both human and veterinary health. The ongoing evolution of antibiotic-resistant pathogens, coupled with limited new antibiotic discoveries, urges the need for …
View article: Umrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024
Umrah- and travel-associated meningococcal disease due to multiple serogroup W ST-11 sub-strains pre-Hajj 2024 Open
The rapid expansion of Umrah/travel-related W:cc11 IMD cases in early 2024 was due to multiple strains/sublineages. Despite the involvement of non-KSA travel-destinations, the coincidence of cases with the busy month of Ramadan, and the ab…
View article: Natural variation of the streptococcal group A carbohydrate biosynthesis genes impacts host–pathogen interaction
Natural variation of the streptococcal group A carbohydrate biosynthesis genes impacts host–pathogen interaction Open
Streptococcus pyogenes is a leading cause of infection-related mortality in humans globally. The characteristic cell wall-anchored group A carbohydrate (GAC) is expressed by all S. pyogenes strains and consists of a polyrhamnose backbone w…
View article: Quantifying the impact of the COVID-19 pandemic on invasive bacterial diseases across 27 countries and territories: prospective surveillance by the IRIS Consortium
Quantifying the impact of the COVID-19 pandemic on invasive bacterial diseases across 27 countries and territories: prospective surveillance by the IRIS Consortium Open
Summary Background Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis are leading causes of invasive bacterial disease worldwide. The aims of this study were to measure post-COVID-19 pandemic changes in the inciden…
View article: The risk of household secondary invasive Group A Streptococcal infections after a prophylaxis policy change in the Netherlands
The risk of household secondary invasive Group A Streptococcal infections after a prophylaxis policy change in the Netherlands Open
Importance Household contacts of patients with invasive group A streptococcal (iGAS) disease have an increased risk of iGAS. In the Netherlands, the iGAS public health policy was changed in January 2023, offering antibiotic prophylaxis to …
View article: Discovery of glycerol phosphate and an immunogenic glycan motif in rhamnose-rich polysaccharides of Streptococcus uberis
Discovery of glycerol phosphate and an immunogenic glycan motif in rhamnose-rich polysaccharides of Streptococcus uberis Open
View article: A conserved glycan motif overcomes antigenic variation inducing broadly reactive antibodies against the zoonotic pathogen<i>Streptococcus suis</i>
A conserved glycan motif overcomes antigenic variation inducing broadly reactive antibodies against the zoonotic pathogen<i>Streptococcus suis</i> Open
Streptococcus suis is a largely neglected but emerging bacterial zoonotic pathogen of global concern for animal welfare, antibiotic resistance development and human health. No effective vaccines are currently available. Here, we identified…
View article: Value of collaborative investigation by hospital infection control, public health services and a national reference laboratory during an increase in puerperal sepsis
Value of collaborative investigation by hospital infection control, public health services and a national reference laboratory during an increase in puerperal sepsis Open
Background In a Dutch tertiary care hospital, two cases of puerperal sepsis were diagnosed within 16 days in June-July 2022. The subsequent outbreak investigation emphasizes the value of collaboration between hospital infection control, re…
View article: Streptococcus pneumoniae serotype 38 emerges as one of the dominant serotypes causing invasive pneumococcal disease in Germany and Poland, but not in the Netherlands
Streptococcus pneumoniae serotype 38 emerges as one of the dominant serotypes causing invasive pneumococcal disease in Germany and Poland, but not in the Netherlands Open
The recent surge in non-vaccine serotype 38 among IPD cases in Germany and Poland cannot be explained by changes in antimicrobial resistance or other genetic changes. Our study underscores the importance of international collaboration in m…
View article: CLR-Seq: a pipeline to identify bacterial microbiota species with immune-relevant glycan moieties through human C-type lectin receptor interaction
CLR-Seq: a pipeline to identify bacterial microbiota species with immune-relevant glycan moieties through human C-type lectin receptor interaction Open
Bacterial glycans are key components in immune interactions. We lack insight into the diverse glycan landscape present in complex microbial communities since currentomics techniques do not capture this post-translational information. Here …
View article: Investigating two decades of Streptococcus pneumoniae bacteraemia in the Gelderland area, the Netherlands, using whole-genome sequencing
Investigating two decades of Streptococcus pneumoniae bacteraemia in the Gelderland area, the Netherlands, using whole-genome sequencing Open
In the Netherlands, the 7-valent pneumococcal conjugate vaccine (PCV) was introduced to the childhood immunization programme in 2006 and replaced by the 10-valent PCV (PCV10, GSK) in 2011. To describe invasive pneumococcal disease in the e…
View article: Single-cell sequencing of human Langerhans cells identifies altered gene expression profiles in patients with atopic dermatitis
Single-cell sequencing of human Langerhans cells identifies altered gene expression profiles in patients with atopic dermatitis Open
Atopic dermatitis (AD) is characterized by dysregulated T cell immunity and skin microbiome dysbiosis with predominance of Staphylococcus aureus, which is associated with exacerbating AD skin inflammation. Specific glycosylation patterns o…
View article: Wall teichoic acid glycosylation of bovine-associated Staphylococcus aureus strains
Wall teichoic acid glycosylation of bovine-associated Staphylococcus aureus strains Open
Staphylococcus aureus (S. aureus) is one of the major causes of bovine mastitis, a disease with detrimental effects on health and wellbeing. Current control measures are costly, laborious and not always effective in eradicating S. aureus. …
View article: <i>Streptococcus pyogenes emm</i> Type 3.93 Emergence, the Netherlands and England
<i>Streptococcus pyogenes emm</i> Type 3.93 Emergence, the Netherlands and England Open
A global increase in the incidence of invasive group A Streptococcus (iGAS) infections was observed after lifting of COVID-19 related restrictions in 2022, and type M1UK dominated in many countries. After seasonal declines in iG…
View article: The importance of microbiology reference laboratories and adequate funding for infectious disease surveillance
The importance of microbiology reference laboratories and adequate funding for infectious disease surveillance Open
View article: Serotype distribution of remaining invasive pneumococcal disease after extensive use of ten-valent and 13-valent pneumococcal conjugate vaccines (the PSERENADE project): a global surveillance analysis
Serotype distribution of remaining invasive pneumococcal disease after extensive use of ten-valent and 13-valent pneumococcal conjugate vaccines (the PSERENADE project): a global surveillance analysis Open
View article: The two-component system ArlRS is essential for wall teichoic acid glycoswitching in <i>Staphylococcus aureus</i>
The two-component system ArlRS is essential for wall teichoic acid glycoswitching in <i>Staphylococcus aureus</i> Open
Staphylococcus aureus is among the leading causes of hospital-acquired infections. Critical to S. aureus biology and pathogenesis are the cell wall-anchored glycopolymers wall teichoic acids (WTA). Approximately one-third of S. aureus isol…
View article: Natural variation of the streptococcal Group A carbohydrate biosynthesis genes impacts host-pathogen interaction
Natural variation of the streptococcal Group A carbohydrate biosynthesis genes impacts host-pathogen interaction Open
Streptococcus pyogenes ( S. pyogenes ) is a leading cause of infection-related mortality in humans globally. The characteristic cell wall-anchored Group A Carbohydrate (GAC) is expressed by all S. pyogenes strains and consists of a polyrha…
View article: Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe
Global Meningococcal Initiative: Insights on antibiotic resistance, control strategies and advocacy efforts in Western Europe Open
View article: Attribution of invasive group A streptococcal infections (iGAS) to predisposing viral infections, the Netherlands, 2010 to 2023
Attribution of invasive group A streptococcal infections (iGAS) to predisposing viral infections, the Netherlands, 2010 to 2023 Open
Background After most COVID-19 pandemic control measures were lifted in 2022, many infectious diseases re-emerged. An increase in invasive group A streptococcal (iGAS) infections among adults and young children was reported by several coun…
View article: Glycan-specific IgM is critical for human immunity to Staphylococcus aureus
Glycan-specific IgM is critical for human immunity to Staphylococcus aureus Open
View article: Nationwide upsurge in invasive disease in the context of longitudinal surveillance of carriage and invasive <i>Streptococcus pyogenes</i> 2009–2023, the Netherlands: a molecular epidemiological study
Nationwide upsurge in invasive disease in the context of longitudinal surveillance of carriage and invasive <i>Streptococcus pyogenes</i> 2009–2023, the Netherlands: a molecular epidemiological study Open
Since 2022, many countries have reported an upsurge in invasive group A streptococcal (iGAS) infections. We explored whether changes in Streptococcus pyogenes carriage rates or emergence of strains with potentially altered virulence, such …
View article: Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands
Genetic markers associated with host status and clonal expansion of Group B Streptococcus in the Netherlands Open
Objectives Certain Group B Streptococcus (GBS) genotypes are associated with invasive disease in neonates. We conducted a comparative genomic analysis of GBS isolates from neonatal disease and maternal carriage in the Netherlands to determ…
View article: Nationwide upsurge in invasive disease in the context of longitudinal surveillance of carriage and invasive<i>Streptococcus pyogenes</i>2009-2023, the Netherlands: a molecular epidemiological study
Nationwide upsurge in invasive disease in the context of longitudinal surveillance of carriage and invasive<i>Streptococcus pyogenes</i>2009-2023, the Netherlands: a molecular epidemiological study Open
Background Since 2022, many countries reported an upsurge in invasive group A streptococcal (iGAS) infections. We explored whether changes in S. pyogenes carriage rates or emergence of more virulent strains, such as emm 1 variants M1 UK an…